Association between Plasma Urotensin II and Risk of Hypertension: Findings from a Prospective Study
Up to date, human urotensin II (UII) is the most potent vasoconstrictor in mammalian animals. To explore whether UII played an important role in the development of hypertension, we conducted a prospective study in Changshu city, China. The baseline investigation was carried out in 2007, and the firs...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2020/3284769 |
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| author | Huijian Xie Xinya Wang Yan He Daoyi Huang Xinyuan Qu Yanbo Jiang Yan An Shaoyan Zhang Mingzhi Zhang |
| author_facet | Huijian Xie Xinya Wang Yan He Daoyi Huang Xinyuan Qu Yanbo Jiang Yan An Shaoyan Zhang Mingzhi Zhang |
| author_sort | Huijian Xie |
| collection | DOAJ |
| description | Up to date, human urotensin II (UII) is the most potent vasoconstrictor in mammalian animals. To explore whether UII played an important role in the development of hypertension, we conducted a prospective study in Changshu city, China. The baseline investigation was carried out in 2007, and the first follow-up investigation was conducted in 2013. From the participants, we randomly obtained 2000 normotensive subjects aged 40 years and older without any severe disease at baseline and examined plasma UII and endothelin-1 (ET-1) with their blood samples at baseline. Logistic models were used to analyze the association between baseline UII, baseline ET-1, and newly occurring hypertension. In 1,819 subjects with complete data, 723 subjects developed into hypertensive in about five years. After adjusting some potential confounders, the odds ratio (95% confidence interval) for risk of hypertension comparing the highest with the lowest quartile of baseline UII was 0.888 (0.689–1.144). The role of UII in the development of hypertension was not found in the current study; therefore, further research studies should be conducted to explore the relationship between UII and hypertension. |
| format | Article |
| id | doaj-art-58a8237d673f4e3fbf144fd014a493a1 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-58a8237d673f4e3fbf144fd014a493a12025-08-20T03:33:38ZengWileyInternational Journal of Hypertension2090-03842090-03922020-01-01202010.1155/2020/32847693284769Association between Plasma Urotensin II and Risk of Hypertension: Findings from a Prospective StudyHuijian Xie0Xinya Wang1Yan He2Daoyi Huang3Xinyuan Qu4Yanbo Jiang5Yan An6Shaoyan Zhang7Mingzhi Zhang8Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, ChinaMacrostat (China) Clinical Research Co., Ltd., Shanghai 200120, ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, ChinaDepartment of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, ChinaUp to date, human urotensin II (UII) is the most potent vasoconstrictor in mammalian animals. To explore whether UII played an important role in the development of hypertension, we conducted a prospective study in Changshu city, China. The baseline investigation was carried out in 2007, and the first follow-up investigation was conducted in 2013. From the participants, we randomly obtained 2000 normotensive subjects aged 40 years and older without any severe disease at baseline and examined plasma UII and endothelin-1 (ET-1) with their blood samples at baseline. Logistic models were used to analyze the association between baseline UII, baseline ET-1, and newly occurring hypertension. In 1,819 subjects with complete data, 723 subjects developed into hypertensive in about five years. After adjusting some potential confounders, the odds ratio (95% confidence interval) for risk of hypertension comparing the highest with the lowest quartile of baseline UII was 0.888 (0.689–1.144). The role of UII in the development of hypertension was not found in the current study; therefore, further research studies should be conducted to explore the relationship between UII and hypertension.http://dx.doi.org/10.1155/2020/3284769 |
| spellingShingle | Huijian Xie Xinya Wang Yan He Daoyi Huang Xinyuan Qu Yanbo Jiang Yan An Shaoyan Zhang Mingzhi Zhang Association between Plasma Urotensin II and Risk of Hypertension: Findings from a Prospective Study International Journal of Hypertension |
| title | Association between Plasma Urotensin II and Risk of Hypertension: Findings from a Prospective Study |
| title_full | Association between Plasma Urotensin II and Risk of Hypertension: Findings from a Prospective Study |
| title_fullStr | Association between Plasma Urotensin II and Risk of Hypertension: Findings from a Prospective Study |
| title_full_unstemmed | Association between Plasma Urotensin II and Risk of Hypertension: Findings from a Prospective Study |
| title_short | Association between Plasma Urotensin II and Risk of Hypertension: Findings from a Prospective Study |
| title_sort | association between plasma urotensin ii and risk of hypertension findings from a prospective study |
| url | http://dx.doi.org/10.1155/2020/3284769 |
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