Roles of Different Signaling Pathways in <i>Cryptococcus neoformans</i> Virulence
<i>Cryptococcus neoformans</i> is a widespread fungal pathogen that can infect the human central nervous system (CNS) and cause fungal meningitis, leading to hundreds of thousands of deaths worldwide each year. Previous studies have demonstrated that many signal transduction pathways are...
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MDPI AG
2024-11-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/10/11/786 |
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| author | Fawad Mahmood Jun-Ming Chen Ammar Mutahar Al-Huthaifi Abdullah Ali Al-Alawi Tong-Bao Liu |
| author_facet | Fawad Mahmood Jun-Ming Chen Ammar Mutahar Al-Huthaifi Abdullah Ali Al-Alawi Tong-Bao Liu |
| author_sort | Fawad Mahmood |
| collection | DOAJ |
| description | <i>Cryptococcus neoformans</i> is a widespread fungal pathogen that can infect the human central nervous system (CNS) and cause fungal meningitis, leading to hundreds of thousands of deaths worldwide each year. Previous studies have demonstrated that many signal transduction pathways are crucial for the morphological development and virulence of <i>C. neoformans</i>. In this review, data from over 116 research articles have been compiled to show that many signaling pathways control various characteristics of <i>C. neoformans</i>, individually or in association with other pathways, and to establish strong links among them to better understand <i>C. neoformans</i> pathogenesis. Every characteristic of <i>C. neoformans</i> is closely linked to these signaling pathways, making this a rich area for further research. It is essential to thoroughly explore these pathways to address questions that remain and apply a molecular mechanistic approach to link them. Targeting these pathways is crucial for understanding the exact mechanism of infection pathogenesis and will facilitate the development of antifungal drugs as well as the diagnosis and prevention of cryptococcosis. |
| format | Article |
| id | doaj-art-58a6dd9d38e242d39cbb3ad1b8adfb64 |
| institution | DOAJ |
| issn | 2309-608X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj-art-58a6dd9d38e242d39cbb3ad1b8adfb642025-08-20T02:47:58ZengMDPI AGJournal of Fungi2309-608X2024-11-01101178610.3390/jof10110786Roles of Different Signaling Pathways in <i>Cryptococcus neoformans</i> VirulenceFawad Mahmood0Jun-Ming Chen1Ammar Mutahar Al-Huthaifi2Abdullah Ali Al-Alawi3Tong-Bao Liu4Medical Research Institute, Southwest University, Chongqing 400715, ChinaState Key Laboratory of Resource Insects, Southwest University, Chongqing 400715, ChinaMedical Research Institute, Southwest University, Chongqing 400715, ChinaMedical Research Institute, Southwest University, Chongqing 400715, ChinaMedical Research Institute, Southwest University, Chongqing 400715, China<i>Cryptococcus neoformans</i> is a widespread fungal pathogen that can infect the human central nervous system (CNS) and cause fungal meningitis, leading to hundreds of thousands of deaths worldwide each year. Previous studies have demonstrated that many signal transduction pathways are crucial for the morphological development and virulence of <i>C. neoformans</i>. In this review, data from over 116 research articles have been compiled to show that many signaling pathways control various characteristics of <i>C. neoformans</i>, individually or in association with other pathways, and to establish strong links among them to better understand <i>C. neoformans</i> pathogenesis. Every characteristic of <i>C. neoformans</i> is closely linked to these signaling pathways, making this a rich area for further research. It is essential to thoroughly explore these pathways to address questions that remain and apply a molecular mechanistic approach to link them. Targeting these pathways is crucial for understanding the exact mechanism of infection pathogenesis and will facilitate the development of antifungal drugs as well as the diagnosis and prevention of cryptococcosis.https://www.mdpi.com/2309-608X/10/11/786<i>Cryptococcus neoformans</i>signaling pathwaysmorphological developmentpathogenicity |
| spellingShingle | Fawad Mahmood Jun-Ming Chen Ammar Mutahar Al-Huthaifi Abdullah Ali Al-Alawi Tong-Bao Liu Roles of Different Signaling Pathways in <i>Cryptococcus neoformans</i> Virulence Journal of Fungi <i>Cryptococcus neoformans</i> signaling pathways morphological development pathogenicity |
| title | Roles of Different Signaling Pathways in <i>Cryptococcus neoformans</i> Virulence |
| title_full | Roles of Different Signaling Pathways in <i>Cryptococcus neoformans</i> Virulence |
| title_fullStr | Roles of Different Signaling Pathways in <i>Cryptococcus neoformans</i> Virulence |
| title_full_unstemmed | Roles of Different Signaling Pathways in <i>Cryptococcus neoformans</i> Virulence |
| title_short | Roles of Different Signaling Pathways in <i>Cryptococcus neoformans</i> Virulence |
| title_sort | roles of different signaling pathways in i cryptococcus neoformans i virulence |
| topic | <i>Cryptococcus neoformans</i> signaling pathways morphological development pathogenicity |
| url | https://www.mdpi.com/2309-608X/10/11/786 |
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