Impact of Punica granatum seeds extract (PSE) on renal and testicular tissues toxicity in mice exposed to iron oxide nanoparticles (IONPs)
Abstract Recently, nano-manufactured materials have been used to treat many diseases, such as healing wounds and other modern biological applications. This study investigates the positive effect of Punica granatum seeds extract on kidney and testicular toxicities induced by iron oxide nanoparticles....
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Nature Portfolio
2024-10-01
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| Online Access: | https://doi.org/10.1038/s41598-024-74410-8 |
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| author | Yasmin M. Abd El-Aziz Fatima S. Alaryani Nesreen Aljahdali Kamlah Ali Majrashi Najah M. Albaqami Marwa S. Khattab El-Sayed Hemdan Eissa Zulhisyam Abdul Kari Ali H. Abu Almaaty |
| author_facet | Yasmin M. Abd El-Aziz Fatima S. Alaryani Nesreen Aljahdali Kamlah Ali Majrashi Najah M. Albaqami Marwa S. Khattab El-Sayed Hemdan Eissa Zulhisyam Abdul Kari Ali H. Abu Almaaty |
| author_sort | Yasmin M. Abd El-Aziz |
| collection | DOAJ |
| description | Abstract Recently, nano-manufactured materials have been used to treat many diseases, such as healing wounds and other modern biological applications. This study investigates the positive effect of Punica granatum seeds extract on kidney and testicular toxicities induced by iron oxide nanoparticles. Forty mice were randomly divided into four groups; the 1st group was the control group. The 2nd group was dosed daily with PSE at 100 g per kg. The 3rd group was dosed with 10 doses of iron oxide nanoparticles at 30 mg/kg b.wt of a mouse per day, 10 times only, then this toxic substance was withdrawn for the rest of the experimental period (30 days). The 4th group was dosed with the same doses as the second and third groups. In this research, we focused on the possibility of using the positive curative effects of PSE, which were estimated at the level of blood chemistry biomarkers, as well as histological and histochemical examinations for the kidney and testis after exposure of mice to iron oxide nanoparticles. These aim to clarify the effect of iron oxide nanoparticles on kidney and testicular morphology and their functions, as well as the potential ameliorative effects of PSE. |
| format | Article |
| id | doaj-art-58a4dd8a589b439fb0b4cce898566dbf |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-58a4dd8a589b439fb0b4cce898566dbf2025-08-20T03:43:26ZengNature PortfolioScientific Reports2045-23222024-10-0114111410.1038/s41598-024-74410-8Impact of Punica granatum seeds extract (PSE) on renal and testicular tissues toxicity in mice exposed to iron oxide nanoparticles (IONPs)Yasmin M. Abd El-Aziz0Fatima S. Alaryani1Nesreen Aljahdali2Kamlah Ali Majrashi3Najah M. Albaqami4Marwa S. Khattab5El-Sayed Hemdan Eissa6Zulhisyam Abdul Kari7Ali H. Abu Almaaty8Department of Zoology, Faculty of Science, Port Said UniversityCollege of Science, Department of Biological Sciences, University of JeddahDepartment of Biological Science, College of Science, King Abdulaziz UniversityBiological Sciences Department, College of Science & Arts, King Abdulaziz UniversityDepartment of Biological Sciences, Faculty of Sciences, King Abdulaziz UniversityDepartment of Pathology, Faculty of Veterinary Medicine, Cairo UniversityFish Research Centre, Faculty of Environmental Agricultural Sciences, Arish UniversityDepartment of Agricultural Sciences, Faculty of Agro-Based Industry, Universiti Malaysia KelantanDepartment of Zoology, Faculty of Science, Port Said UniversityAbstract Recently, nano-manufactured materials have been used to treat many diseases, such as healing wounds and other modern biological applications. This study investigates the positive effect of Punica granatum seeds extract on kidney and testicular toxicities induced by iron oxide nanoparticles. Forty mice were randomly divided into four groups; the 1st group was the control group. The 2nd group was dosed daily with PSE at 100 g per kg. The 3rd group was dosed with 10 doses of iron oxide nanoparticles at 30 mg/kg b.wt of a mouse per day, 10 times only, then this toxic substance was withdrawn for the rest of the experimental period (30 days). The 4th group was dosed with the same doses as the second and third groups. In this research, we focused on the possibility of using the positive curative effects of PSE, which were estimated at the level of blood chemistry biomarkers, as well as histological and histochemical examinations for the kidney and testis after exposure of mice to iron oxide nanoparticles. These aim to clarify the effect of iron oxide nanoparticles on kidney and testicular morphology and their functions, as well as the potential ameliorative effects of PSE.https://doi.org/10.1038/s41598-024-74410-8BiomarkersHistochemicalIONPsKidneyPSETestis |
| spellingShingle | Yasmin M. Abd El-Aziz Fatima S. Alaryani Nesreen Aljahdali Kamlah Ali Majrashi Najah M. Albaqami Marwa S. Khattab El-Sayed Hemdan Eissa Zulhisyam Abdul Kari Ali H. Abu Almaaty Impact of Punica granatum seeds extract (PSE) on renal and testicular tissues toxicity in mice exposed to iron oxide nanoparticles (IONPs) Scientific Reports Biomarkers Histochemical IONPs Kidney PSE Testis |
| title | Impact of Punica granatum seeds extract (PSE) on renal and testicular tissues toxicity in mice exposed to iron oxide nanoparticles (IONPs) |
| title_full | Impact of Punica granatum seeds extract (PSE) on renal and testicular tissues toxicity in mice exposed to iron oxide nanoparticles (IONPs) |
| title_fullStr | Impact of Punica granatum seeds extract (PSE) on renal and testicular tissues toxicity in mice exposed to iron oxide nanoparticles (IONPs) |
| title_full_unstemmed | Impact of Punica granatum seeds extract (PSE) on renal and testicular tissues toxicity in mice exposed to iron oxide nanoparticles (IONPs) |
| title_short | Impact of Punica granatum seeds extract (PSE) on renal and testicular tissues toxicity in mice exposed to iron oxide nanoparticles (IONPs) |
| title_sort | impact of punica granatum seeds extract pse on renal and testicular tissues toxicity in mice exposed to iron oxide nanoparticles ionps |
| topic | Biomarkers Histochemical IONPs Kidney PSE Testis |
| url | https://doi.org/10.1038/s41598-024-74410-8 |
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