TSC complex decrease the expression of mTOR by regulated miR-199b-3p

TSC complex decrease the expression of mTOR by regulated miR-199b-3p

Abstract The TSC complex formed by TSC1 and TSC2 is the most important upstream negative regulator of mTORC1. Genetic variations in either TSC1 or TSC2 cause tuberous sclerosis complex (TSC) disease which is a rare autosomal dominant disorder resulting in impairment of multiple organ systems. In thi...

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Bibliographic Details
Main Authors: Na Zhao, Qiuhong Xiong, Ping Li, Guangxin Chen, Han Xiao, Changxin Wu
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
TSC1
TSC2
MTOR
MiR-199b-3p
TSC
Online Access:https://doi.org/10.1038/s41598-025-85706-8
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