3-Hydroxybutyrate, a metabolite in sustaining neuronal cell vitality: a mendelian randomization and in vitro experimentation

3-Hydroxybutyrate, a metabolite in sustaining neuronal cell vitality: a mendelian randomization and in vitro experimentation

Abstract Background Recent research has implicated mitochondrial DNA copy number (mtDNA-CN) and Tau protein levels in the blood as potential biomarkers for early Alzheimer’s disease (AD) risk assessment, correlating with metabolite profiles. However, intermediary metabolites mediating these associat...

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Main Authors: Xiaoling Hu, Yu Lin, Kaiwen Huang, HuiLin Xu, Changmei Huang Fu, Jiayin Ou, Xiude Fan, Zhe Li, Jiansong Fang, Shuhuan Fang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Nutrition & Metabolism
Subjects:
Mitochondrial DNA copy number
Metabolites
3-Hydroxybutyrate
Tau
Mendelian randomization
HT22 cells
Online Access:https://doi.org/10.1186/s12986-025-00960-x
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