MicroRNAs in adipose tissue fibrosis: Mechanisms and therapeutic potential
Adipose tissue fibrosis, characterized by abnormal extracellular matrix deposition within adipose tissue, signifies a crucial indicator of adipose tissue malfunction, potentially leading to organ tissue dysfunction. Various factors, including a high-fat diet, non-alcoholic fatty liver disease, and i...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2025-07-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304224000849 |
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| author | Mei Tian Yang Zhou Yitong Guo Qing Xia Zehua Wang Xinying Zheng Jinze Shen Junping Guo Shiwei Duan Lijun Wang |
| author_facet | Mei Tian Yang Zhou Yitong Guo Qing Xia Zehua Wang Xinying Zheng Jinze Shen Junping Guo Shiwei Duan Lijun Wang |
| author_sort | Mei Tian |
| collection | DOAJ |
| description | Adipose tissue fibrosis, characterized by abnormal extracellular matrix deposition within adipose tissue, signifies a crucial indicator of adipose tissue malfunction, potentially leading to organ tissue dysfunction. Various factors, including a high-fat diet, non-alcoholic fatty liver disease, and insulin resistance, coincide with adipose tissue fibrosis. MicroRNAs (miRNAs) represent a class of small non-coding RNAs with significant influence on tissue fibrosis through diverse signaling pathways. For instance, in response to a high-fat diet, miRNAs can modulate signaling pathways such as TGF-β/Smad, PI3K/AKT, and PPAR-γ to impact adipose tissue fibrosis. Furthermore, miRNAs play roles in inhibiting fibrosis in different contexts: suppressing corneal fibrosis via the TGF-β/Smad pathway, mitigating cardiac fibrosis through the VEGF signaling pathway, reducing wound fibrosis via regulation of the MAPK signaling pathway, and diminishing fibrosis post-fat transplantation via involvement in the PDGFR-β signaling pathway. Notably, the secretome released by miRNA-transfected adipose-derived stem cells facilitates targeted delivery of miRNAs to evade host immune rejection, enhancing their anti-fibrotic efficacy. Hence, this study endeavors to elucidate the role and mechanism of miRNAs in adipose tissue fibrosis and explore the mechanisms and advantages of the secretome released by miRNA-transfected adipose-derived stem cells in combating fibrotic diseases. |
| format | Article |
| id | doaj-art-5896c7ae5e5c4d25aa5d7f2ae02d27f2 |
| institution | OA Journals |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-5896c7ae5e5c4d25aa5d7f2ae02d27f22025-08-20T02:11:26ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-07-0112410128710.1016/j.gendis.2024.101287MicroRNAs in adipose tissue fibrosis: Mechanisms and therapeutic potentialMei Tian0Yang Zhou1Yitong Guo2Qing Xia3Zehua Wang4Xinying Zheng5Jinze Shen6Junping Guo7Shiwei Duan8Lijun Wang9College of Pharmacy, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China; Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310014, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, ChinaCollege of Pharmacy, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, ChinaCollege of Pharmacy, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, ChinaRainbowfish Rehabilitation and Nursing School, Hangzhou Vocational & Technical College, Hangzhou, Zhejiang 310018, China; Department of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, China; Corresponding author.Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang 310014, China; Corresponding author.Adipose tissue fibrosis, characterized by abnormal extracellular matrix deposition within adipose tissue, signifies a crucial indicator of adipose tissue malfunction, potentially leading to organ tissue dysfunction. Various factors, including a high-fat diet, non-alcoholic fatty liver disease, and insulin resistance, coincide with adipose tissue fibrosis. MicroRNAs (miRNAs) represent a class of small non-coding RNAs with significant influence on tissue fibrosis through diverse signaling pathways. For instance, in response to a high-fat diet, miRNAs can modulate signaling pathways such as TGF-β/Smad, PI3K/AKT, and PPAR-γ to impact adipose tissue fibrosis. Furthermore, miRNAs play roles in inhibiting fibrosis in different contexts: suppressing corneal fibrosis via the TGF-β/Smad pathway, mitigating cardiac fibrosis through the VEGF signaling pathway, reducing wound fibrosis via regulation of the MAPK signaling pathway, and diminishing fibrosis post-fat transplantation via involvement in the PDGFR-β signaling pathway. Notably, the secretome released by miRNA-transfected adipose-derived stem cells facilitates targeted delivery of miRNAs to evade host immune rejection, enhancing their anti-fibrotic efficacy. Hence, this study endeavors to elucidate the role and mechanism of miRNAs in adipose tissue fibrosis and explore the mechanisms and advantages of the secretome released by miRNA-transfected adipose-derived stem cells in combating fibrotic diseases.http://www.sciencedirect.com/science/article/pii/S2352304224000849Adipose tissue fibrosisAdipose-derived stem cellExtracellular matrixmiRNAsSignaling pathways |
| spellingShingle | Mei Tian Yang Zhou Yitong Guo Qing Xia Zehua Wang Xinying Zheng Jinze Shen Junping Guo Shiwei Duan Lijun Wang MicroRNAs in adipose tissue fibrosis: Mechanisms and therapeutic potential Genes and Diseases Adipose tissue fibrosis Adipose-derived stem cell Extracellular matrix miRNAs Signaling pathways |
| title | MicroRNAs in adipose tissue fibrosis: Mechanisms and therapeutic potential |
| title_full | MicroRNAs in adipose tissue fibrosis: Mechanisms and therapeutic potential |
| title_fullStr | MicroRNAs in adipose tissue fibrosis: Mechanisms and therapeutic potential |
| title_full_unstemmed | MicroRNAs in adipose tissue fibrosis: Mechanisms and therapeutic potential |
| title_short | MicroRNAs in adipose tissue fibrosis: Mechanisms and therapeutic potential |
| title_sort | micrornas in adipose tissue fibrosis mechanisms and therapeutic potential |
| topic | Adipose tissue fibrosis Adipose-derived stem cell Extracellular matrix miRNAs Signaling pathways |
| url | http://www.sciencedirect.com/science/article/pii/S2352304224000849 |
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