Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature

Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature

Abstract Background Aging, mild cognitive impairment (MCI), Alzheimer’s disease (AD), and individuals at risk for AD are associated with impaired negative blood-oxygen-level-dependent (BOLD) response (NBR) in task-evoked functional magnetic resonance imaging (fMRI) studies. In addition, autosomal do...

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Bibliographic Details
Main Authors: Bardiya Ghaderi Yazdi, Qolamreza R. Razlighi
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Functional MRI
Task performance
Deactivation
Neuropsychological tests
N-back
Episodic memory
Online Access:https://doi.org/10.1186/s12967-025-06721-x
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