An XBB.1.5-based inactivated SARS-CoV-2 vaccine partially protects against XBB.1.5 and JN.1 strains in hamsters
Abstract The SARS-CoV-2 Omicron BA.2.86 variant and its descendant lineages, including JN.1, are rapidly spreading and becoming dominant globally. Vaccination is an essential primary preventative measure. While mRNA vaccines have been widely used worldwide, it is essential that we continue to prepar...
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| Format: | Article |
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Nature Portfolio
2025-02-01
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| Series: | npj Viruses |
| Online Access: | https://doi.org/10.1038/s44298-025-00096-y |
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| author | Ryuta Uraki Mutsumi Ito Maki Kiso Kiyoko Iwatsuki-Horimoto Masafumi Endo Seiya Yamayoshi Yoshihiro Kawaoka |
| author_facet | Ryuta Uraki Mutsumi Ito Maki Kiso Kiyoko Iwatsuki-Horimoto Masafumi Endo Seiya Yamayoshi Yoshihiro Kawaoka |
| author_sort | Ryuta Uraki |
| collection | DOAJ |
| description | Abstract The SARS-CoV-2 Omicron BA.2.86 variant and its descendant lineages, including JN.1, are rapidly spreading and becoming dominant globally. Vaccination is an essential primary preventative measure. While mRNA vaccines have been widely used worldwide, it is essential that we continue to prepare alternative vaccine modalities. Consistent with WHO recommendations, we developed an inactivated Omicron XBB.1.5 vaccine and assessed its efficacy against XBB.1.5 and JN.1 strains. Immunization with the inactivated XBB.1.5 vaccine induced antigen-specific antibodies leading to protection from XBB.1.5 and antigenically distinct JN.1 strains in a hamster model. In addition, we found that immunization reduced viral replication in hamster respiratory organs, suggesting protection against XBB.1.5 and JN.1 variants. Our findings highlight the potential of inactivated vaccines against evolving SARS-CoV-2 variants. |
| format | Article |
| id | doaj-art-58940eb2b6bd4b8cb5030b60b6e2b44c |
| institution | Kabale University |
| issn | 2948-1767 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Viruses |
| spelling | doaj-art-58940eb2b6bd4b8cb5030b60b6e2b44c2025-02-09T12:16:14ZengNature Portfolionpj Viruses2948-17672025-02-01311510.1038/s44298-025-00096-yAn XBB.1.5-based inactivated SARS-CoV-2 vaccine partially protects against XBB.1.5 and JN.1 strains in hamstersRyuta Uraki0Mutsumi Ito1Maki Kiso2Kiyoko Iwatsuki-Horimoto3Masafumi Endo4Seiya Yamayoshi5Yoshihiro Kawaoka6The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research InstituteDivision of Virology, Institute of Medical Science, The University of TokyoThe University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (The UTOPIA Center), Institutes for Advanced Study, The University of TokyoThe University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (The UTOPIA Center), Institutes for Advanced Study, The University of TokyoKM Biologics Co. Ltd. (KM Biologics)The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research InstituteThe Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research InstituteAbstract The SARS-CoV-2 Omicron BA.2.86 variant and its descendant lineages, including JN.1, are rapidly spreading and becoming dominant globally. Vaccination is an essential primary preventative measure. While mRNA vaccines have been widely used worldwide, it is essential that we continue to prepare alternative vaccine modalities. Consistent with WHO recommendations, we developed an inactivated Omicron XBB.1.5 vaccine and assessed its efficacy against XBB.1.5 and JN.1 strains. Immunization with the inactivated XBB.1.5 vaccine induced antigen-specific antibodies leading to protection from XBB.1.5 and antigenically distinct JN.1 strains in a hamster model. In addition, we found that immunization reduced viral replication in hamster respiratory organs, suggesting protection against XBB.1.5 and JN.1 variants. Our findings highlight the potential of inactivated vaccines against evolving SARS-CoV-2 variants.https://doi.org/10.1038/s44298-025-00096-y |
| spellingShingle | Ryuta Uraki Mutsumi Ito Maki Kiso Kiyoko Iwatsuki-Horimoto Masafumi Endo Seiya Yamayoshi Yoshihiro Kawaoka An XBB.1.5-based inactivated SARS-CoV-2 vaccine partially protects against XBB.1.5 and JN.1 strains in hamsters npj Viruses |
| title | An XBB.1.5-based inactivated SARS-CoV-2 vaccine partially protects against XBB.1.5 and JN.1 strains in hamsters |
| title_full | An XBB.1.5-based inactivated SARS-CoV-2 vaccine partially protects against XBB.1.5 and JN.1 strains in hamsters |
| title_fullStr | An XBB.1.5-based inactivated SARS-CoV-2 vaccine partially protects against XBB.1.5 and JN.1 strains in hamsters |
| title_full_unstemmed | An XBB.1.5-based inactivated SARS-CoV-2 vaccine partially protects against XBB.1.5 and JN.1 strains in hamsters |
| title_short | An XBB.1.5-based inactivated SARS-CoV-2 vaccine partially protects against XBB.1.5 and JN.1 strains in hamsters |
| title_sort | xbb 1 5 based inactivated sars cov 2 vaccine partially protects against xbb 1 5 and jn 1 strains in hamsters |
| url | https://doi.org/10.1038/s44298-025-00096-y |
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