Ovarian cancer unmasked by technetium-99m bone scintigraphy and single-photon emission computed tomography-computed tomography
We report a case of a 30-year-old female patient with a painless palpable nodule in the chest wall, evaluated for osseous involvement by technetium-99m (Tc-99m) bone scintigraphy. A whole-body scan revealed numerous sites of increased tracer accumulation throughout the thorax, abdomen, and pelvis. S...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2019-01-01
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| Series: | World Journal of Nuclear Medicine |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_66_17 |
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| author | Jolien Verschueren Ivan Huyghe Tim Van den Wyngaert |
| author_facet | Jolien Verschueren Ivan Huyghe Tim Van den Wyngaert |
| author_sort | Jolien Verschueren |
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| description | We report a case of a 30-year-old female patient with a painless palpable nodule in the chest wall, evaluated for osseous involvement by technetium-99m (Tc-99m) bone scintigraphy. A whole-body scan revealed numerous sites of increased tracer accumulation throughout the thorax, abdomen, and pelvis. Subsequent single-photon emission computed tomography-computed tomography (SPECT-CT) of the abdomen and pelvis showed no abnormal uptake in the bone; however, significant nonosseous tracer accumulation in calcified soft tissue metastases was noted. Pathology confirmed a high-grade ovarian papillary serous adenocarcinoma. Extraosseous uptake of bone-seeking agents in the body is often incidental findings and can be explained by various benign and malignant conditions with soft tissue calcification. In our case report, this unusual finding on bone scintigraphy was highly suggestive for malignancy, initially not considered during the clinical evaluation of the patient. It also illustrates the usefulness of additional hybrid SPECT-CT to precisely localize extraosseous uptake of Tc-99m methylene diphoshonate. |
| format | Article |
| id | doaj-art-5893f92bb4b2473f82c7398c5b4ac62d |
| institution | OA Journals |
| issn | 1450-1147 1607-3312 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | World Journal of Nuclear Medicine |
| spelling | doaj-art-5893f92bb4b2473f82c7398c5b4ac62d2025-08-20T01:56:59ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122019-01-011801586010.4103/wjnm.WJNM_66_17Ovarian cancer unmasked by technetium-99m bone scintigraphy and single-photon emission computed tomography-computed tomographyJolien Verschueren0Ivan Huyghe1Tim Van den Wyngaert2Department of Nuclear Medicine, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Nuclear Medicine, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Nuclear Medicine, Antwerp University Hospital, 2650 Edegem, BelgiumWe report a case of a 30-year-old female patient with a painless palpable nodule in the chest wall, evaluated for osseous involvement by technetium-99m (Tc-99m) bone scintigraphy. A whole-body scan revealed numerous sites of increased tracer accumulation throughout the thorax, abdomen, and pelvis. Subsequent single-photon emission computed tomography-computed tomography (SPECT-CT) of the abdomen and pelvis showed no abnormal uptake in the bone; however, significant nonosseous tracer accumulation in calcified soft tissue metastases was noted. Pathology confirmed a high-grade ovarian papillary serous adenocarcinoma. Extraosseous uptake of bone-seeking agents in the body is often incidental findings and can be explained by various benign and malignant conditions with soft tissue calcification. In our case report, this unusual finding on bone scintigraphy was highly suggestive for malignancy, initially not considered during the clinical evaluation of the patient. It also illustrates the usefulness of additional hybrid SPECT-CT to precisely localize extraosseous uptake of Tc-99m methylene diphoshonate.http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_66_17bone scintigraphyovarian cancersingle-photon emission computed tomography-computed tomographysoft tissue metastasestechnetium-99m methylene diphoshonate |
| spellingShingle | Jolien Verschueren Ivan Huyghe Tim Van den Wyngaert Ovarian cancer unmasked by technetium-99m bone scintigraphy and single-photon emission computed tomography-computed tomography World Journal of Nuclear Medicine bone scintigraphy ovarian cancer single-photon emission computed tomography-computed tomography soft tissue metastases technetium-99m methylene diphoshonate |
| title | Ovarian cancer unmasked by technetium-99m bone scintigraphy and single-photon emission computed tomography-computed tomography |
| title_full | Ovarian cancer unmasked by technetium-99m bone scintigraphy and single-photon emission computed tomography-computed tomography |
| title_fullStr | Ovarian cancer unmasked by technetium-99m bone scintigraphy and single-photon emission computed tomography-computed tomography |
| title_full_unstemmed | Ovarian cancer unmasked by technetium-99m bone scintigraphy and single-photon emission computed tomography-computed tomography |
| title_short | Ovarian cancer unmasked by technetium-99m bone scintigraphy and single-photon emission computed tomography-computed tomography |
| title_sort | ovarian cancer unmasked by technetium 99m bone scintigraphy and single photon emission computed tomography computed tomography |
| topic | bone scintigraphy ovarian cancer single-photon emission computed tomography-computed tomography soft tissue metastases technetium-99m methylene diphoshonate |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/wjnm.WJNM_66_17 |
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