Oxidative Lactamization of Amino Alcohols: An Overview
Lactams are essential functional groups in a number of pharmacologically and biologically active compounds. They are widely found in many natural products, marketed drugs, as well as in the base of polymeric structures (e.g., polyamides/Nylons). In this context, it is quite important to develop nove...
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| Language: | English |
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Iranian Chemical Science and Technologies Association
2020-02-01
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| Series: | Journal of Chemistry Letters |
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| Online Access: | https://www.jchemlett.com/article_106645_2fca09cfaab25e4f55bc7a458a79786f.pdf |
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| author | Lakashima Sreerama Esmail Vessally Farnaz Behmagham |
| author_facet | Lakashima Sreerama Esmail Vessally Farnaz Behmagham |
| author_sort | Lakashima Sreerama |
| collection | DOAJ |
| description | Lactams are essential functional groups in a number of pharmacologically and biologically active compounds. They are widely found in many natural products, marketed drugs, as well as in the base of polymeric structures (e.g., polyamides/Nylons). In this context, it is quite important to develop novel and efficient methods for the synthesis of these compounds. Recently, intramolecular dehydrogenative coupling reactions of amino alcohols, which generate only hydrogen as a side product, have emerged as one of the most versatile and powerful synthetic strategies to construct lactam rings. In the present review we will discuss recent advances on this chemistry with the emphasis on the mechanistic aspects of the reactions. |
| format | Article |
| id | doaj-art-5893cabb82c54007942c1eb2f2eba5b7 |
| institution | DOAJ |
| issn | 2821-0123 2717-1892 |
| language | English |
| publishDate | 2020-02-01 |
| publisher | Iranian Chemical Science and Technologies Association |
| record_format | Article |
| series | Journal of Chemistry Letters |
| spelling | doaj-art-5893cabb82c54007942c1eb2f2eba5b72025-08-20T03:16:45ZengIranian Chemical Science and Technologies AssociationJournal of Chemistry Letters2821-01232717-18922020-02-011191810.22034/jchemlett.2020.106645106645Oxidative Lactamization of Amino Alcohols: An OverviewLakashima Sreerama0Esmail Vessally1Farnaz Behmagham2Department of Chemistry, Qatar University, QatarPayame Noor University, Tehran, IranMiandoab Branch , Islamic Azad University, Miandoab, IranLactams are essential functional groups in a number of pharmacologically and biologically active compounds. They are widely found in many natural products, marketed drugs, as well as in the base of polymeric structures (e.g., polyamides/Nylons). In this context, it is quite important to develop novel and efficient methods for the synthesis of these compounds. Recently, intramolecular dehydrogenative coupling reactions of amino alcohols, which generate only hydrogen as a side product, have emerged as one of the most versatile and powerful synthetic strategies to construct lactam rings. In the present review we will discuss recent advances on this chemistry with the emphasis on the mechanistic aspects of the reactions.https://www.jchemlett.com/article_106645_2fca09cfaab25e4f55bc7a458a79786f.pdfcoronavirus sarscov2 covid19 drug design world health organization (who) |
| spellingShingle | Lakashima Sreerama Esmail Vessally Farnaz Behmagham Oxidative Lactamization of Amino Alcohols: An Overview Journal of Chemistry Letters coronavirus sars cov 2 covid 19 drug design world health organization (who) |
| title | Oxidative Lactamization of Amino Alcohols: An Overview |
| title_full | Oxidative Lactamization of Amino Alcohols: An Overview |
| title_fullStr | Oxidative Lactamization of Amino Alcohols: An Overview |
| title_full_unstemmed | Oxidative Lactamization of Amino Alcohols: An Overview |
| title_short | Oxidative Lactamization of Amino Alcohols: An Overview |
| title_sort | oxidative lactamization of amino alcohols an overview |
| topic | coronavirus sars cov 2 covid 19 drug design world health organization (who) |
| url | https://www.jchemlett.com/article_106645_2fca09cfaab25e4f55bc7a458a79786f.pdf |
| work_keys_str_mv | AT lakashimasreerama oxidativelactamizationofaminoalcoholsanoverview AT esmailvessally oxidativelactamizationofaminoalcoholsanoverview AT farnazbehmagham oxidativelactamizationofaminoalcoholsanoverview |