NK-DC Crosstalk in Immunity to Microbial Infection

The interaction between natural killer (NK) cell and dendritic cell (DC), two important cellular components of innate immunity, started to be elucidated in the last years. The crosstalk between NK cells and DC, which leads to NK cell activation, DC maturation, or apoptosis, involves cell-cell contac...

Full description

Saved in:
Bibliographic Details
Main Authors: Rony Thomas, Xi Yang
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Journal of Immunology Research
Online Access:http://dx.doi.org/10.1155/2016/6374379
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832559831613964288
author Rony Thomas
Xi Yang
author_facet Rony Thomas
Xi Yang
author_sort Rony Thomas
collection DOAJ
description The interaction between natural killer (NK) cell and dendritic cell (DC), two important cellular components of innate immunity, started to be elucidated in the last years. The crosstalk between NK cells and DC, which leads to NK cell activation, DC maturation, or apoptosis, involves cell-cell contacts and soluble factors. This interaction either in the periphery or in the secondary lymphoid organs acts as a key player linking innate and adaptive immune responses to microbial stimuli. This review focuses on the mechanisms of NK-DC interaction and their relevance in antimicrobial responses. We specifically aim to emphasize the ability of various microbial infections to differently influence NK-DC crosstalk thereby contributing to distinct adaptive immune response.
format Article
id doaj-art-58932f0ebb7d4ea8a86033b0b801d6d4
institution Kabale University
issn 2314-8861
2314-7156
language English
publishDate 2016-01-01
publisher Wiley
record_format Article
series Journal of Immunology Research
spelling doaj-art-58932f0ebb7d4ea8a86033b0b801d6d42025-02-03T01:29:11ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/63743796374379NK-DC Crosstalk in Immunity to Microbial InfectionRony Thomas0Xi Yang1Department of Immunology, Faculty of Medicine, University of Manitoba, 471 Apotex Centre, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, CanadaDepartment of Immunology, Faculty of Medicine, University of Manitoba, 471 Apotex Centre, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, CanadaThe interaction between natural killer (NK) cell and dendritic cell (DC), two important cellular components of innate immunity, started to be elucidated in the last years. The crosstalk between NK cells and DC, which leads to NK cell activation, DC maturation, or apoptosis, involves cell-cell contacts and soluble factors. This interaction either in the periphery or in the secondary lymphoid organs acts as a key player linking innate and adaptive immune responses to microbial stimuli. This review focuses on the mechanisms of NK-DC interaction and their relevance in antimicrobial responses. We specifically aim to emphasize the ability of various microbial infections to differently influence NK-DC crosstalk thereby contributing to distinct adaptive immune response.http://dx.doi.org/10.1155/2016/6374379
spellingShingle Rony Thomas
Xi Yang
NK-DC Crosstalk in Immunity to Microbial Infection
Journal of Immunology Research
title NK-DC Crosstalk in Immunity to Microbial Infection
title_full NK-DC Crosstalk in Immunity to Microbial Infection
title_fullStr NK-DC Crosstalk in Immunity to Microbial Infection
title_full_unstemmed NK-DC Crosstalk in Immunity to Microbial Infection
title_short NK-DC Crosstalk in Immunity to Microbial Infection
title_sort nk dc crosstalk in immunity to microbial infection
url http://dx.doi.org/10.1155/2016/6374379
work_keys_str_mv AT ronythomas nkdccrosstalkinimmunitytomicrobialinfection
AT xiyang nkdccrosstalkinimmunitytomicrobialinfection