NK-DC Crosstalk in Immunity to Microbial Infection
The interaction between natural killer (NK) cell and dendritic cell (DC), two important cellular components of innate immunity, started to be elucidated in the last years. The crosstalk between NK cells and DC, which leads to NK cell activation, DC maturation, or apoptosis, involves cell-cell contac...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/6374379 |
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| _version_ | 1832559831613964288 |
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| author | Rony Thomas Xi Yang |
| author_facet | Rony Thomas Xi Yang |
| author_sort | Rony Thomas |
| collection | DOAJ |
| description | The interaction between natural killer (NK) cell and dendritic cell (DC), two important cellular components of innate immunity, started to be elucidated in the last years. The crosstalk between NK cells and DC, which leads to NK cell activation, DC maturation, or apoptosis, involves cell-cell contacts and soluble factors. This interaction either in the periphery or in the secondary lymphoid organs acts as a key player linking innate and adaptive immune responses to microbial stimuli. This review focuses on the mechanisms of NK-DC interaction and their relevance in antimicrobial responses. We specifically aim to emphasize the ability of various microbial infections to differently influence NK-DC crosstalk thereby contributing to distinct adaptive immune response. |
| format | Article |
| id | doaj-art-58932f0ebb7d4ea8a86033b0b801d6d4 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-58932f0ebb7d4ea8a86033b0b801d6d42025-02-03T01:29:11ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/63743796374379NK-DC Crosstalk in Immunity to Microbial InfectionRony Thomas0Xi Yang1Department of Immunology, Faculty of Medicine, University of Manitoba, 471 Apotex Centre, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, CanadaDepartment of Immunology, Faculty of Medicine, University of Manitoba, 471 Apotex Centre, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, CanadaThe interaction between natural killer (NK) cell and dendritic cell (DC), two important cellular components of innate immunity, started to be elucidated in the last years. The crosstalk between NK cells and DC, which leads to NK cell activation, DC maturation, or apoptosis, involves cell-cell contacts and soluble factors. This interaction either in the periphery or in the secondary lymphoid organs acts as a key player linking innate and adaptive immune responses to microbial stimuli. This review focuses on the mechanisms of NK-DC interaction and their relevance in antimicrobial responses. We specifically aim to emphasize the ability of various microbial infections to differently influence NK-DC crosstalk thereby contributing to distinct adaptive immune response.http://dx.doi.org/10.1155/2016/6374379 |
| spellingShingle | Rony Thomas Xi Yang NK-DC Crosstalk in Immunity to Microbial Infection Journal of Immunology Research |
| title | NK-DC Crosstalk in Immunity to Microbial Infection |
| title_full | NK-DC Crosstalk in Immunity to Microbial Infection |
| title_fullStr | NK-DC Crosstalk in Immunity to Microbial Infection |
| title_full_unstemmed | NK-DC Crosstalk in Immunity to Microbial Infection |
| title_short | NK-DC Crosstalk in Immunity to Microbial Infection |
| title_sort | nk dc crosstalk in immunity to microbial infection |
| url | http://dx.doi.org/10.1155/2016/6374379 |
| work_keys_str_mv | AT ronythomas nkdccrosstalkinimmunitytomicrobialinfection AT xiyang nkdccrosstalkinimmunitytomicrobialinfection |