Prospective hospital-based cohort studies of Respiratory Syncytial Virus (RSV) infections in infants under one year during and after the SARS-CoV-2 pandemic in Japan

Objectives: In Japan, population-based epidemiological data on respiratory syncytial virus (RSV) infections are limited. To elucidate the epidemiology of RSV before the introduction of new prophylactic drugs, we conducted a population-based study during and after the SARS-CoV-2 pandemic. Methods: Th...

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Main Authors: Koo Nagasawa, Mihoko Ohata, Ataru Igarashi, Takeshi Arashiro, Tomoko Ogawa, Misako Ohkusu, Noriko Takeuchi, Kenichi Shizuno, Erika Kurihara, Misato Yoshida, Takahiro Kodama, Katsuaki Abe, Tadashi Hoshino, Junko Arii, Kenichi Takeshita, Haruka Hishiki, Setsuo Ota, Yoshiko Takahashi, Yuko Omata, Tomoko Nakazawa, Tomohiro Someya, Naruhiko Ishiwada
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:International Journal of Infectious Diseases
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Online Access:http://www.sciencedirect.com/science/article/pii/S1201971224003230
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author Koo Nagasawa
Mihoko Ohata
Ataru Igarashi
Takeshi Arashiro
Tomoko Ogawa
Misako Ohkusu
Noriko Takeuchi
Kenichi Shizuno
Erika Kurihara
Misato Yoshida
Takahiro Kodama
Katsuaki Abe
Tadashi Hoshino
Junko Arii
Kenichi Takeshita
Haruka Hishiki
Setsuo Ota
Yoshiko Takahashi
Yuko Omata
Tomoko Nakazawa
Tomohiro Someya
Naruhiko Ishiwada
author_facet Koo Nagasawa
Mihoko Ohata
Ataru Igarashi
Takeshi Arashiro
Tomoko Ogawa
Misako Ohkusu
Noriko Takeuchi
Kenichi Shizuno
Erika Kurihara
Misato Yoshida
Takahiro Kodama
Katsuaki Abe
Tadashi Hoshino
Junko Arii
Kenichi Takeshita
Haruka Hishiki
Setsuo Ota
Yoshiko Takahashi
Yuko Omata
Tomoko Nakazawa
Tomohiro Someya
Naruhiko Ishiwada
author_sort Koo Nagasawa
collection DOAJ
description Objectives: In Japan, population-based epidemiological data on respiratory syncytial virus (RSV) infections are limited. To elucidate the epidemiology of RSV before the introduction of new prophylactic drugs, we conducted a population-based study during and after the SARS-CoV-2 pandemic. Methods: This study was performed in four hospitals in Chiba City and three hospitals in Ichihara City. Clinical information and residual samples from RSV rapid antigen tests of infants under one year old were collected. Samples from patients with lower respiratory tract infections (LRTI) were analyzed using the FilmArray Respiratory 2.1 panels. Results: A total of 1200 infants underwent the RSV rapid antigen test, with 497 diagnosed with LRTI. Although five samples could not be stored, 252 out of 492 (51.2%) were positive for RSV. Among the RSV PCR-positive infants, 63 (25.0%) had underlying diseases, compared to 100 out of 240 (41.7%) RSV PCR-negative infants (P < 0.05). In Chiba City, the annual incidence of hospitalization per 1000 children was 12.7 in 2021, 4.4 in 2022, and 9.2 in 2023. Conclusions: During and after the SARS-CoV-2 pandemic, most hospitalized infants with RSV-LRTI did not have underlying diseases. Widespread use of prophylaxis in infants without underlying disease is desirable.
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spelling doaj-art-589295e40488456aa1267420731b4e672025-08-20T02:07:01ZengElsevierInternational Journal of Infectious Diseases1201-97122024-12-0114910725210.1016/j.ijid.2024.107252Prospective hospital-based cohort studies of Respiratory Syncytial Virus (RSV) infections in infants under one year during and after the SARS-CoV-2 pandemic in JapanKoo Nagasawa0Mihoko Ohata1Ataru Igarashi2Takeshi Arashiro3Tomoko Ogawa4Misako Ohkusu5Noriko Takeuchi6Kenichi Shizuno7Erika Kurihara8Misato Yoshida9Takahiro Kodama10Katsuaki Abe11Tadashi Hoshino12Junko Arii13Kenichi Takeshita14Haruka Hishiki15Setsuo Ota16Yoshiko Takahashi17Yuko Omata18Tomoko Nakazawa19Tomohiro Someya20Naruhiko Ishiwada21Department of Pediatrics, Chiba University Hospital, Chiba-city, Chiba, JapanDepartment of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba-city, Chiba, JapanDepartment of Public Health, Yokohama City University School of Medicine, Yokohama-city, Kanagawa, JapanSanofi Vaccines Medical, Shinjuku-ku, Tokyo, JapanDepartment of Pediatrics, Chiba University Hospital, Chiba-city, Chiba, Japan; Department of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba-city, Chiba, JapanDepartment of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba-city, Chiba, JapanDepartment of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba-city, Chiba, JapanDepartment of Clinical Laboratory, Chiba Kaihin Municipal Hospital, Chiba-city, Chiba, JapanDepartment of Pediatrics, Chiba University Hospital, Chiba-city, Chiba, Japan; Department of Pediatrics, Chiba Kaihin Municipal Hospital, Chiba-city, Chiba, JapanDepartment of Pediatrics, Chiba Kaihin Municipal Hospital, Chiba-city, Chiba, JapanDepartment of Pediatrics, Chiba Kaihin Municipal Hospital, Chiba-city, Chiba, JapanDepartment of Pediatrics, Kamagaya General Hospital, Kamagaya-city, Chiba, JapanDepartment of Infectious Diseases, Chiba Children's Hospital, Chiba-city, Chiba, JapanDepartment of Pediatrics, Chiba Rosai Hospital, Ichihara-city, Chiba, JapanDepartment of Pediatrics, Chiba Rosai Hospital, Ichihara-city, Chiba, JapanDepartment of Pediatrics, Teikyo University Chiba Medical Center, Ichihara-city, Chiba, JapanDepartment of Pediatrics, Teikyo University Chiba Medical Center, Ichihara-city, Chiba, JapanDepartment of Pediatrics, Seikei-kai Chiba Medical Center, Chiba-city, Chiba, JapanDepartment of Pediatrics, Seikei-kai Chiba Medical Center, Chiba-city, Chiba, JapanDepartment of Pediatrics, Seikei-kai Chiba Medical Center, Chiba-city, Chiba, JapanDepartment of Pediatrics, Goi Hospital, Ichihara-city, Chiba, JapanDepartment of Infectious Diseases, Medical Mycology Research Center, Chiba University, Chiba-city, Chiba, Japan; Corresponding author.Objectives: In Japan, population-based epidemiological data on respiratory syncytial virus (RSV) infections are limited. To elucidate the epidemiology of RSV before the introduction of new prophylactic drugs, we conducted a population-based study during and after the SARS-CoV-2 pandemic. Methods: This study was performed in four hospitals in Chiba City and three hospitals in Ichihara City. Clinical information and residual samples from RSV rapid antigen tests of infants under one year old were collected. Samples from patients with lower respiratory tract infections (LRTI) were analyzed using the FilmArray Respiratory 2.1 panels. Results: A total of 1200 infants underwent the RSV rapid antigen test, with 497 diagnosed with LRTI. Although five samples could not be stored, 252 out of 492 (51.2%) were positive for RSV. Among the RSV PCR-positive infants, 63 (25.0%) had underlying diseases, compared to 100 out of 240 (41.7%) RSV PCR-negative infants (P < 0.05). In Chiba City, the annual incidence of hospitalization per 1000 children was 12.7 in 2021, 4.4 in 2022, and 9.2 in 2023. Conclusions: During and after the SARS-CoV-2 pandemic, most hospitalized infants with RSV-LRTI did not have underlying diseases. Widespread use of prophylaxis in infants without underlying disease is desirable.http://www.sciencedirect.com/science/article/pii/S1201971224003230Respiratory syncytial virusEpidemiologyHospitalization ratePopulationInfants
spellingShingle Koo Nagasawa
Mihoko Ohata
Ataru Igarashi
Takeshi Arashiro
Tomoko Ogawa
Misako Ohkusu
Noriko Takeuchi
Kenichi Shizuno
Erika Kurihara
Misato Yoshida
Takahiro Kodama
Katsuaki Abe
Tadashi Hoshino
Junko Arii
Kenichi Takeshita
Haruka Hishiki
Setsuo Ota
Yoshiko Takahashi
Yuko Omata
Tomoko Nakazawa
Tomohiro Someya
Naruhiko Ishiwada
Prospective hospital-based cohort studies of Respiratory Syncytial Virus (RSV) infections in infants under one year during and after the SARS-CoV-2 pandemic in Japan
International Journal of Infectious Diseases
Respiratory syncytial virus
Epidemiology
Hospitalization rate
Population
Infants
title Prospective hospital-based cohort studies of Respiratory Syncytial Virus (RSV) infections in infants under one year during and after the SARS-CoV-2 pandemic in Japan
title_full Prospective hospital-based cohort studies of Respiratory Syncytial Virus (RSV) infections in infants under one year during and after the SARS-CoV-2 pandemic in Japan
title_fullStr Prospective hospital-based cohort studies of Respiratory Syncytial Virus (RSV) infections in infants under one year during and after the SARS-CoV-2 pandemic in Japan
title_full_unstemmed Prospective hospital-based cohort studies of Respiratory Syncytial Virus (RSV) infections in infants under one year during and after the SARS-CoV-2 pandemic in Japan
title_short Prospective hospital-based cohort studies of Respiratory Syncytial Virus (RSV) infections in infants under one year during and after the SARS-CoV-2 pandemic in Japan
title_sort prospective hospital based cohort studies of respiratory syncytial virus rsv infections in infants under one year during and after the sars cov 2 pandemic in japan
topic Respiratory syncytial virus
Epidemiology
Hospitalization rate
Population
Infants
url http://www.sciencedirect.com/science/article/pii/S1201971224003230
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