PRACTICE OF USING VIRAL PROTEASE INHIBITORS IN CHILDREN WITH HIV INFECTION
Selection of the most effective and safest high-active antiretroviral therapies is a critical issue faced by modern HIV medicine. Authors studied 28 children with HIV infection aged from 3 to 7 divided into two groups administered a combination of two HIV reverse transcriptase nucleoside inhibitors...
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| Format: | Article |
| Language: | Russian |
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Union of pediatricians of Russia
2010-02-01
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| Series: | Педиатрическая фармакология |
| Online Access: | https://www.pedpharma.ru/jour/article/view/1198 |
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| author | V.B. Denisenko E.N. Simovan'yan E.V. Beketova |
| author_facet | V.B. Denisenko E.N. Simovan'yan E.V. Beketova |
| author_sort | V.B. Denisenko |
| collection | DOAJ |
| description | Selection of the most effective and safest high-active antiretroviral therapies is a critical issue faced by modern HIV medicine. Authors studied 28 children with HIV infection aged from 3 to 7 divided into two groups administered a combination of two HIV reverse transcriptase nucleoside inhibitors with viral protease nelfinavir inhibitors (n = 13) and lopinavir/ritonavir (n = 15). The subjects in both groups demonstrated a decreased frequency of HIV-associated symptoms and opportunistic infections, positive dynamics of immunological indicators, suppression of HIV replication. When lopinavir/ritonavir was administered, there was more even better dynamics in clinical, immunological and virologic parameters, which allows this medication to be recommended as a antiretroviral therapy for children. Key words: HIV infection, lopinavir/ritonavir, nelfinavir, children. (Pediatric Pharmacology. – 2010; 7(1):62-67) |
| format | Article |
| id | doaj-art-58909cc7da0f404d85b4cf0b59b50e9c |
| institution | DOAJ |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2010-02-01 |
| publisher | Union of pediatricians of Russia |
| record_format | Article |
| series | Педиатрическая фармакология |
| spelling | doaj-art-58909cc7da0f404d85b4cf0b59b50e9c2025-08-20T02:54:23ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892010-02-017162671193PRACTICE OF USING VIRAL PROTEASE INHIBITORS IN CHILDREN WITH HIV INFECTIONV.B. Denisenko0E.N. Simovan'yan1E.V. Beketova2State Educational Institution of Higher Professional Education «Rostov State Medical University of the Federal Health-Care and Social Development Agency»State Health-Care Institution «The Centre for Prevention and Fight Against AIDS and Infectious Diseases» in the Rostov RegionState Educational Institution of Higher Professional Education «Rostov State Medical University of the Federal Health-Care and Social Development Agency»Selection of the most effective and safest high-active antiretroviral therapies is a critical issue faced by modern HIV medicine. Authors studied 28 children with HIV infection aged from 3 to 7 divided into two groups administered a combination of two HIV reverse transcriptase nucleoside inhibitors with viral protease nelfinavir inhibitors (n = 13) and lopinavir/ritonavir (n = 15). The subjects in both groups demonstrated a decreased frequency of HIV-associated symptoms and opportunistic infections, positive dynamics of immunological indicators, suppression of HIV replication. When lopinavir/ritonavir was administered, there was more even better dynamics in clinical, immunological and virologic parameters, which allows this medication to be recommended as a antiretroviral therapy for children. Key words: HIV infection, lopinavir/ritonavir, nelfinavir, children. (Pediatric Pharmacology. – 2010; 7(1):62-67)https://www.pedpharma.ru/jour/article/view/1198 |
| spellingShingle | V.B. Denisenko E.N. Simovan'yan E.V. Beketova PRACTICE OF USING VIRAL PROTEASE INHIBITORS IN CHILDREN WITH HIV INFECTION Педиатрическая фармакология |
| title | PRACTICE OF USING VIRAL PROTEASE INHIBITORS IN CHILDREN WITH HIV INFECTION |
| title_full | PRACTICE OF USING VIRAL PROTEASE INHIBITORS IN CHILDREN WITH HIV INFECTION |
| title_fullStr | PRACTICE OF USING VIRAL PROTEASE INHIBITORS IN CHILDREN WITH HIV INFECTION |
| title_full_unstemmed | PRACTICE OF USING VIRAL PROTEASE INHIBITORS IN CHILDREN WITH HIV INFECTION |
| title_short | PRACTICE OF USING VIRAL PROTEASE INHIBITORS IN CHILDREN WITH HIV INFECTION |
| title_sort | practice of using viral protease inhibitors in children with hiv infection |
| url | https://www.pedpharma.ru/jour/article/view/1198 |
| work_keys_str_mv | AT vbdenisenko practiceofusingviralproteaseinhibitorsinchildrenwithhivinfection AT ensimovanyan practiceofusingviralproteaseinhibitorsinchildrenwithhivinfection AT evbeketova practiceofusingviralproteaseinhibitorsinchildrenwithhivinfection |