Neuroprotective and anticonvulsant effect of trimetazidine in a PTZ-kindling model of mice through modulation of the IL-1β/IL-1R1 and HMGB-1/TLR-4 axis

Neuroprotective and anticonvulsant effect of trimetazidine in a PTZ-kindling model of mice through modulation of the IL-1β/IL-1R1 and HMGB-1/TLR-4 axis

BackgroundEpilepsy is a chronic and complex brain disorder characterized by frequent seizures, cognitive impairments, neuroinflammation, oxidative stress, and imbalances in neurotransmitters. Developing an effective therapeutic intervention to target these pathological interventions remains a challe...

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Bibliographic Details
Main Authors:	Shahnawaz Ahmad, Mohammed Samim, Seema Jain, Divya Vohora, Nidhi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Pharmacology
Subjects:	epilepsy cognition trimetazidine PTZ-kindling neuroinflammation oxidative stress
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1621729/full
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