Integration of single-nuclei and spatial transcriptomics to decipher tumor phenotype predictive of relapse-free survival in Wilms tumor

BackgroundWilms tumor (WT) is the most common childhood renal malignancy, with recurrence linked to poor prognosis. Identifying the molecular features of tumor phenotypes that drive recurrence and discovering novel targets are crucial for improving treatment strategies and enhancing patient outcomes...

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Bibliographic Details
Main Authors:	Ran Yang, Lulu Xie, Rui Wang, Yi Li, Yifei Lu, Baihui Liu, Shuyang Dai, Shan Zheng, Kuiran Dong, Rui Dong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Series:	Frontiers in Immunology
Subjects:	Wilms tumor recurrence cancer stem cell machine learning immune microenvironment
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1539897/full
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Integration of single-nuclei and spatial transcriptomics to decipher tumor phenotype predictive of relapse-free survival in Wilms tumor

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