Engineering chiral mesoporous silica nanoparticles: Template design and structural control for advanced applications
Chiral mesoporous silica nanoparticles (CMSNs) are a distinct subset of mesoporous silica nanoparticles, combining the favorable physicochemical properties of MSNs with unique chiral architectures at both molecular and macroscopic scales. These helical structures endow CMSNs with specialized functio...
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KeAi Communications Co., Ltd.
2025-12-01
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| Series: | Supramolecular Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667240525000042 |
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| author | Yu Yin Wu Wei Kai Zhang |
| author_facet | Yu Yin Wu Wei Kai Zhang |
| author_sort | Yu Yin |
| collection | DOAJ |
| description | Chiral mesoporous silica nanoparticles (CMSNs) are a distinct subset of mesoporous silica nanoparticles, combining the favorable physicochemical properties of MSNs with unique chiral architectures at both molecular and macroscopic scales. These helical structures endow CMSNs with specialized functionalities, enabling their applications in chiral catalysis, enantioselective recognition, chiral separation, drug delivery, and optical devices, making them a focal point in materials and biomedical research. Significant progress has been achieved in the synthesis of CMSNs, particularly in understanding the mechanisms of chirality formation and the critical role of surfactant templates in guiding chiral structures. This review summarizes these advancements, emphasizing experimental and theoretical insights. Key applications of CMSNs, especially in drug delivery systems, are explored in detail, highlighting their potential to enhance bioavailability and therapeutic efficacy. Looking ahead, CMSN research presents exciting opportunities, including precise control over chiral structures, the development of novel templating strategies, and the exploration of broader applications. These advancements are expected to drive progress in nanoporous silica technologies and open new frontiers in materials science and nanomedicine. |
| format | Article |
| id | doaj-art-588986434e48440bae89e173640f22c7 |
| institution | Kabale University |
| issn | 2667-2405 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Supramolecular Materials |
| spelling | doaj-art-588986434e48440bae89e173640f22c72025-01-29T05:02:22ZengKeAi Communications Co., Ltd.Supramolecular Materials2667-24052025-12-014100095Engineering chiral mesoporous silica nanoparticles: Template design and structural control for advanced applicationsYu Yin0Wu Wei1Kai Zhang2Sustainable Materials and Chemistry, Department of Wood Technology and Wood-based Composites, University of Göttingen, 37077 Göttingen, Germany; Key Laboratory of Bio-based Material Science & Technology, Ministry of Education, Northeast Forestry University, 150040 Harbin, Heilongjiang, ChinaSustainable Materials and Chemistry, Department of Wood Technology and Wood-based Composites, University of Göttingen, 37077 Göttingen, GermanySustainable Materials and Chemistry, Department of Wood Technology and Wood-based Composites, University of Göttingen, 37077 Göttingen, Germany; Biotechnology Center (Biotechnikum), University of Göttingen, 37077 Göttingen, Germany; Corresponding author.Chiral mesoporous silica nanoparticles (CMSNs) are a distinct subset of mesoporous silica nanoparticles, combining the favorable physicochemical properties of MSNs with unique chiral architectures at both molecular and macroscopic scales. These helical structures endow CMSNs with specialized functionalities, enabling their applications in chiral catalysis, enantioselective recognition, chiral separation, drug delivery, and optical devices, making them a focal point in materials and biomedical research. Significant progress has been achieved in the synthesis of CMSNs, particularly in understanding the mechanisms of chirality formation and the critical role of surfactant templates in guiding chiral structures. This review summarizes these advancements, emphasizing experimental and theoretical insights. Key applications of CMSNs, especially in drug delivery systems, are explored in detail, highlighting their potential to enhance bioavailability and therapeutic efficacy. Looking ahead, CMSN research presents exciting opportunities, including precise control over chiral structures, the development of novel templating strategies, and the exploration of broader applications. These advancements are expected to drive progress in nanoporous silica technologies and open new frontiers in materials science and nanomedicine.http://www.sciencedirect.com/science/article/pii/S2667240525000042Chiral mesoporous silica nanoparticles (CMSNS)Helical structuresChirality formationSurfactant templatesDrug delivery systems |
| spellingShingle | Yu Yin Wu Wei Kai Zhang Engineering chiral mesoporous silica nanoparticles: Template design and structural control for advanced applications Supramolecular Materials Chiral mesoporous silica nanoparticles (CMSNS) Helical structures Chirality formation Surfactant templates Drug delivery systems |
| title | Engineering chiral mesoporous silica nanoparticles: Template design and structural control for advanced applications |
| title_full | Engineering chiral mesoporous silica nanoparticles: Template design and structural control for advanced applications |
| title_fullStr | Engineering chiral mesoporous silica nanoparticles: Template design and structural control for advanced applications |
| title_full_unstemmed | Engineering chiral mesoporous silica nanoparticles: Template design and structural control for advanced applications |
| title_short | Engineering chiral mesoporous silica nanoparticles: Template design and structural control for advanced applications |
| title_sort | engineering chiral mesoporous silica nanoparticles template design and structural control for advanced applications |
| topic | Chiral mesoporous silica nanoparticles (CMSNS) Helical structures Chirality formation Surfactant templates Drug delivery systems |
| url | http://www.sciencedirect.com/science/article/pii/S2667240525000042 |
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