Icariin promotes functional recovery in rats after spinal cord injury by inhibiting YAP and regulating PPM1B ubiquitination to inhibiting the activation of reactive astrocytes

Icariin promotes functional recovery in rats after spinal cord injury by inhibiting YAP and regulating PPM1B ubiquitination to inhibiting the activation of reactive astrocytes

ObjectiveThe limited ability to regenerate axons after spinal cord injury (SCI) is influenced by factors such as astrocyte activation, reactive proliferation, and glial scar formation. The TGF-β/Smad (transforming growth factor-β/mothers against decapentaplegic homolog) pathway, associated with astr...

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Bibliographic Details
Main Authors: Sa Feng, Linyan Liu, Yuelin Cheng, Mengmeng Zhou, Haoqiang Zhu, Xinyan Zhao, Ziyu Chen, Shunli Kan, Xuanhao Fu, Wei Hu, Rusen Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Pharmacology
Subjects:
spinal cord injury
icariin
reactive astrogliosis
YAP
PPM1B
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1434652/full
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