Long non-coding RNA involved in the carcinogenesis of human female cancer - a comprehensive review
Abstract Recent years have seen an increase in our understanding of lncRNA and their role in various disease states. lncRNA molecules have been shown to contribute to carcinogenesis and influence the various cancer hallmarks and signalling pathways. It is pertinent to understand the specific contrib...
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| Format: | Article |
| Language: | English |
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Springer
2025-02-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01848-1 |
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| author | Nazia Afroze Madhumitha K. Sundaram Shafiul Haque Arif Hussain |
| author_facet | Nazia Afroze Madhumitha K. Sundaram Shafiul Haque Arif Hussain |
| author_sort | Nazia Afroze |
| collection | DOAJ |
| description | Abstract Recent years have seen an increase in our understanding of lncRNA and their role in various disease states. lncRNA molecules have been shown to contribute to carcinogenesis and influence the various cancer hallmarks and signalling pathways. It is pertinent to understand the specific contributions and mechanisms of action of these molecules in various cancers. This review provides an overview of the various lncRNA entities that influence and regulate the gynaecological cancers, namely, cervical, breast, ovarian and uterine cancers. The review curates a list of the key players and their effect on cellular processes. lncRNA molecules show immense potential to be used as diagnostic and prognostic indicators and in therapeutic strategies. Several phytochemicals, small molecules, RNA-based regulators, oligos and gene editing tools show promise as a therapeutic strategy. While this review highlights the promising developments in this field, it also underscores the necessity for further research to delineate the complex role of lncRNAs in cancer. |
| format | Article |
| id | doaj-art-5885bad6b877453cae2bcce408f5fbed |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-5885bad6b877453cae2bcce408f5fbed2025-02-09T12:43:36ZengSpringerDiscover Oncology2730-60112025-02-0116113110.1007/s12672-025-01848-1Long non-coding RNA involved in the carcinogenesis of human female cancer - a comprehensive reviewNazia Afroze0Madhumitha K. Sundaram1Shafiul Haque2Arif Hussain3School of Life Sciences, Manipal Academy of Higher EducationSchool of Life Sciences, Manipal Academy of Higher EducationDepartment of Nursing, College of Nursing and Health Sciences, Jazan UniversitySchool of Life Sciences, Manipal Academy of Higher EducationAbstract Recent years have seen an increase in our understanding of lncRNA and their role in various disease states. lncRNA molecules have been shown to contribute to carcinogenesis and influence the various cancer hallmarks and signalling pathways. It is pertinent to understand the specific contributions and mechanisms of action of these molecules in various cancers. This review provides an overview of the various lncRNA entities that influence and regulate the gynaecological cancers, namely, cervical, breast, ovarian and uterine cancers. The review curates a list of the key players and their effect on cellular processes. lncRNA molecules show immense potential to be used as diagnostic and prognostic indicators and in therapeutic strategies. Several phytochemicals, small molecules, RNA-based regulators, oligos and gene editing tools show promise as a therapeutic strategy. While this review highlights the promising developments in this field, it also underscores the necessity for further research to delineate the complex role of lncRNAs in cancer.https://doi.org/10.1007/s12672-025-01848-1CancerlncRNAsiRNARNA-basedPhytochemicalsTherapeutics |
| spellingShingle | Nazia Afroze Madhumitha K. Sundaram Shafiul Haque Arif Hussain Long non-coding RNA involved in the carcinogenesis of human female cancer - a comprehensive review Discover Oncology Cancer lncRNA siRNA RNA-based Phytochemicals Therapeutics |
| title | Long non-coding RNA involved in the carcinogenesis of human female cancer - a comprehensive review |
| title_full | Long non-coding RNA involved in the carcinogenesis of human female cancer - a comprehensive review |
| title_fullStr | Long non-coding RNA involved in the carcinogenesis of human female cancer - a comprehensive review |
| title_full_unstemmed | Long non-coding RNA involved in the carcinogenesis of human female cancer - a comprehensive review |
| title_short | Long non-coding RNA involved in the carcinogenesis of human female cancer - a comprehensive review |
| title_sort | long non coding rna involved in the carcinogenesis of human female cancer a comprehensive review |
| topic | Cancer lncRNA siRNA RNA-based Phytochemicals Therapeutics |
| url | https://doi.org/10.1007/s12672-025-01848-1 |
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