Mitochondrial uptake and translocation by macrophages promotes vascular regeneration in peripheral ischemia
Mitochondrial transplantation promotes cardiac repair following injury; however, its effects on limb ischemia due to peripheral artery disease (PAD) remain unclear. In this study, transplantation with mitochondria isolated from both murine muscle tissue and human arterial blood significantly promote...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-10-01
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| Series: | Bioactive Materials |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25002865 |
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| author | Xiaolei Sun Kanghui Chen Peng Wang Yawei Jin Sanli Qian Bingyu li Jianguo Jia Zhenzhong Zhang Chunjie Yang Junbo Ge Aijun Sun |
| author_facet | Xiaolei Sun Kanghui Chen Peng Wang Yawei Jin Sanli Qian Bingyu li Jianguo Jia Zhenzhong Zhang Chunjie Yang Junbo Ge Aijun Sun |
| author_sort | Xiaolei Sun |
| collection | DOAJ |
| description | Mitochondrial transplantation promotes cardiac repair following injury; however, its effects on limb ischemia due to peripheral artery disease (PAD) remain unclear. In this study, transplantation with mitochondria isolated from both murine muscle tissue and human arterial blood significantly promotes revascularization and blood flow recovery in a hindlimb ischemia mouse model. Our findings further show that transplanted mitochondria promote macrophages infiltrating into ischemic regions. Additionally, internalization of the mitochondria promotes macrophage M2-like polarization, resulting in increased pro-angiogenic factors expression and secretion and subsequent endothelial cell and smooth muscle cell proliferation. In conclusion, mitochondrial transplantation shows considerable potential in improving peripheral ischemia and provides therapeutic options for patients with PAD. |
| format | Article |
| id | doaj-art-587d836feba344299db63c54895aecaa |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-10-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-587d836feba344299db63c54895aecaa2025-08-24T05:13:50ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-10-015284585610.1016/j.bioactmat.2025.06.050Mitochondrial uptake and translocation by macrophages promotes vascular regeneration in peripheral ischemiaXiaolei Sun0Kanghui Chen1Peng Wang2Yawei Jin3Sanli Qian4Bingyu li5Jianguo Jia6Zhenzhong Zhang7Chunjie Yang8Junbo Ge9Aijun Sun10Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; State Key Laboratory of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Ischemic Heart Diseases, Shanghai, China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, ChinaDepartment of Emergency Medicine, Shanghai Pudong New Area Gongli Hospital, Shanghai, ChinaDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; State Key Laboratory of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Ischemic Heart Diseases, Shanghai, China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, ChinaDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; State Key Laboratory of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Ischemic Heart Diseases, Shanghai, China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, ChinaDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; State Key Laboratory of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Ischemic Heart Diseases, Shanghai, China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, ChinaDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; State Key Laboratory of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Ischemic Heart Diseases, Shanghai, China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, ChinaDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; State Key Laboratory of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Ischemic Heart Diseases, Shanghai, China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, ChinaDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; State Key Laboratory of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Ischemic Heart Diseases, Shanghai, China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, ChinaDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; State Key Laboratory of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Ischemic Heart Diseases, Shanghai, China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, ChinaDepartment of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; State Key Laboratory of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Ischemic Heart Diseases, Shanghai, China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, China; Corresponding author. Department of Cardiology, Zhongshan Hospital, Fudan University, No. 180 of Rd Fenglin, District Xuhui, Shanghai, 200032, China.Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China; State Key Laboratory of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China; NHC Key Laboratory of Ischemic Heart Diseases, Shanghai, China; Key Laboratory of Viral Heart Diseases, Chinese Academy of Medical Sciences, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, China; Corresponding author. Department of Cardiology, Zhongshan Hospital, Fudan University, No. 180 of Rd Fenglin, District Xuhui, Shanghai, 200032, China.Mitochondrial transplantation promotes cardiac repair following injury; however, its effects on limb ischemia due to peripheral artery disease (PAD) remain unclear. In this study, transplantation with mitochondria isolated from both murine muscle tissue and human arterial blood significantly promotes revascularization and blood flow recovery in a hindlimb ischemia mouse model. Our findings further show that transplanted mitochondria promote macrophages infiltrating into ischemic regions. Additionally, internalization of the mitochondria promotes macrophage M2-like polarization, resulting in increased pro-angiogenic factors expression and secretion and subsequent endothelial cell and smooth muscle cell proliferation. In conclusion, mitochondrial transplantation shows considerable potential in improving peripheral ischemia and provides therapeutic options for patients with PAD.http://www.sciencedirect.com/science/article/pii/S2452199X25002865 |
| spellingShingle | Xiaolei Sun Kanghui Chen Peng Wang Yawei Jin Sanli Qian Bingyu li Jianguo Jia Zhenzhong Zhang Chunjie Yang Junbo Ge Aijun Sun Mitochondrial uptake and translocation by macrophages promotes vascular regeneration in peripheral ischemia Bioactive Materials |
| title | Mitochondrial uptake and translocation by macrophages promotes vascular regeneration in peripheral ischemia |
| title_full | Mitochondrial uptake and translocation by macrophages promotes vascular regeneration in peripheral ischemia |
| title_fullStr | Mitochondrial uptake and translocation by macrophages promotes vascular regeneration in peripheral ischemia |
| title_full_unstemmed | Mitochondrial uptake and translocation by macrophages promotes vascular regeneration in peripheral ischemia |
| title_short | Mitochondrial uptake and translocation by macrophages promotes vascular regeneration in peripheral ischemia |
| title_sort | mitochondrial uptake and translocation by macrophages promotes vascular regeneration in peripheral ischemia |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X25002865 |
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