Investigation of the bone density in multiple sclerosis
A number of investigations revealed a problem of osteopenic syndrome in patients with multiple sclerosis but there is no common opinion concerning factors which lead to its development. We observed 65 patients with multiple sclerosis with various type of its course and disability status of several d...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2008-06-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3376 |
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| author | O. S. Dranichnikova V. D. Zavadovskaya V. M. Alifirova |
| author_facet | O. S. Dranichnikova V. D. Zavadovskaya V. M. Alifirova |
| author_sort | O. S. Dranichnikova |
| collection | DOAJ |
| description | A number of investigations revealed a problem of osteopenic syndrome in patients with multiple sclerosis but there is no common opinion concerning factors which lead to its development. We observed 65 patients with multiple sclerosis with various type of its course and disability status of several degree based upon EDSS scale. Ultrasound osteometry of the calcaneus, computer tomography of QCT of L1—L3 vertebras were performed, serum crosslaps, N-MID osteocalcin were used. Decreased bone density, injured bone microarchitectonics and suppression of bone formation and resorption, which were correlated EDSS were found. Correlations with other factors (growth, weight, gender, and number of steroid therapy sessions ) for these parameters was not revealed. This allowed to conclude that the main reason of decreased bone mass in patients with multiple sclerosis is the dramatic decrease in physical activity. |
| format | Article |
| id | doaj-art-5878d8a511af4aab8db7b4b3fb859eb7 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2008-06-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-5878d8a511af4aab8db7b4b3fb859eb72025-08-20T03:37:17ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842008-06-0172465110.20538/1682-0363-2008-2-46-512032Investigation of the bone density in multiple sclerosisO. S. Dranichnikova0V. D. Zavadovskaya1V. M. Alifirova2Сибирский государственный медицинский университетСибирский государственный медицинский университетСибирский государственный медицинский университетA number of investigations revealed a problem of osteopenic syndrome in patients with multiple sclerosis but there is no common opinion concerning factors which lead to its development. We observed 65 patients with multiple sclerosis with various type of its course and disability status of several degree based upon EDSS scale. Ultrasound osteometry of the calcaneus, computer tomography of QCT of L1—L3 vertebras were performed, serum crosslaps, N-MID osteocalcin were used. Decreased bone density, injured bone microarchitectonics and suppression of bone formation and resorption, which were correlated EDSS were found. Correlations with other factors (growth, weight, gender, and number of steroid therapy sessions ) for these parameters was not revealed. This allowed to conclude that the main reason of decreased bone mass in patients with multiple sclerosis is the dramatic decrease in physical activity.https://bulletin.ssmu.ru/jour/article/view/3376рассеянный склерозкостная прочностьостеопенический синдромosteopenic syndromemultiple sclerosisbone density |
| spellingShingle | O. S. Dranichnikova V. D. Zavadovskaya V. M. Alifirova Investigation of the bone density in multiple sclerosis Бюллетень сибирской медицины рассеянный склероз костная прочность остеопенический синдром osteopenic syndrome multiple sclerosis bone density |
| title | Investigation of the bone density in multiple sclerosis |
| title_full | Investigation of the bone density in multiple sclerosis |
| title_fullStr | Investigation of the bone density in multiple sclerosis |
| title_full_unstemmed | Investigation of the bone density in multiple sclerosis |
| title_short | Investigation of the bone density in multiple sclerosis |
| title_sort | investigation of the bone density in multiple sclerosis |
| topic | рассеянный склероз костная прочность остеопенический синдром osteopenic syndrome multiple sclerosis bone density |
| url | https://bulletin.ssmu.ru/jour/article/view/3376 |
| work_keys_str_mv | AT osdranichnikova investigationofthebonedensityinmultiplesclerosis AT vdzavadovskaya investigationofthebonedensityinmultiplesclerosis AT vmalifirova investigationofthebonedensityinmultiplesclerosis |