Primary lymphomas of the genitourinary tract: A population-based study
Objective: We performed a population-based analysis focusing on primary extranodal lymphoma of either testis, kidney, bladder or prostate (PGUL). Methods: We identified all cases of localized testis, renal, bladder and prostate primary lymphomas (PL) versus primary testis, kidney, bladder and prosta...
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Elsevier
2020-10-01
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| Series: | Asian Journal of Urology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388219301122 |
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| author | Carlotta Palumbo Elio Mazzone Francesco A. Mistretta Sophie Knipper Zhe Tian Paul Perrotte Francesco Montorsi Shahrokh F. Shariat Fred Saad Claudio Simeone Alberto Briganti Alessandro Antonelli Pierre I. Karakiewicz |
| author_facet | Carlotta Palumbo Elio Mazzone Francesco A. Mistretta Sophie Knipper Zhe Tian Paul Perrotte Francesco Montorsi Shahrokh F. Shariat Fred Saad Claudio Simeone Alberto Briganti Alessandro Antonelli Pierre I. Karakiewicz |
| author_sort | Carlotta Palumbo |
| collection | DOAJ |
| description | Objective: We performed a population-based analysis focusing on primary extranodal lymphoma of either testis, kidney, bladder or prostate (PGUL). Methods: We identified all cases of localized testis, renal, bladder and prostate primary lymphomas (PL) versus primary testis, kidney, bladder and prostate cancers within the Surveillance, Epidemiology, and End Results database (1998–2015). Estimated annual proportion change methodology (EAPC), multivariable logistic regression models, cumulative incidence plots and multivariable competing risks regression models were used. Results: The rates of testis-PL, renal-PL, bladder-PL and prostate-PL were 3.04%, 0.22%, 0.18% and 0.01%, respectively. Patients with PGUL were older and more frequently Caucasian. Annual rates significantly decreased for renal-PL (EAPC: −5.6%; p=0.004) and prostate-PL (EAPC: −3.6%; p=0.03). In multivariable logistic regression models, older ager independently predicted testis-PL (odds ratio [OR]: 16.4; p<0.001) and renal-PL (OR: 3.5; p<0.001), while female gender independently predicted bladder-PL (OR: 5.5; p<0.001). In surgically treated patients, cumulative incidence plots showed significantly higher 10-year cancer-specific mortality (CSM) rates for testis-PL, renal-PL and prostate-PL versus their primary genitourinary tumors. In multivariable competing risks regression models, only testis-PL (hazard ratio [HR]: 16.7; p<0.001) and renal-PL (HR: 2.52; p<0.001) independently predicted higher CSM rates. Conclusion: PGUL rates are extremely low and on the decrease in kidney and prostate but stable in testis and bladder. Relative to primary genitourinary tumors, PGUL are associated with worse CSM for testis-PL and renal-PL but not for bladder-PL and prostate-PL, even after adjustment for other-cause mortality. |
| format | Article |
| id | doaj-art-58722fb8c3ca496e910a421ea6ed58a7 |
| institution | Kabale University |
| issn | 2214-3882 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
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| series | Asian Journal of Urology |
| spelling | doaj-art-58722fb8c3ca496e910a421ea6ed58a72025-08-20T03:48:41ZengElsevierAsian Journal of Urology2214-38822020-10-017433233910.1016/j.ajur.2019.11.002Primary lymphomas of the genitourinary tract: A population-based studyCarlotta Palumbo0Elio Mazzone1Francesco A. Mistretta2Sophie Knipper3Zhe Tian4Paul Perrotte5Francesco Montorsi6Shahrokh F. Shariat7Fred Saad8Claudio Simeone9Alberto Briganti10Alessandro Antonelli11Pierre I. Karakiewicz12Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada; Urology Unit, ASST Spedali Civili of Brescia, Department of Medical and Surgical Specialties, Radiological Science and Public Health, University of Brescia, Brescia, ItalyCancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada; Division of Experimental Oncology, Unit of Urology, Urological Research Institute (URI), IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, ItalyCancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada; Department of Urology, European Institute of Oncology, Milan, ItalyCancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada; Martini Klinik, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyCancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, CanadaDivision of Urology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, CanadaDivision of Experimental Oncology, Unit of Urology, Urological Research Institute (URI), IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, ItalyDepartment of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, Weill Cornell Medical College, New York, NY, USA; Department of Urology, University of Texas Southwestern, Dallas, TX, USA; Department of Urology, Second Faculty of Medicine, Charles University, Prag, Czech Republic; Institute for Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Moscow, RussiaCancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada; Division of Urology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, CanadaUrology Unit, ASST Spedali Civili of Brescia, Department of Medical and Surgical Specialties, Radiological Science and Public Health, University of Brescia, Brescia, ItalyDivision of Experimental Oncology, Unit of Urology, Urological Research Institute (URI), IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, ItalyUrology Unit, ASST Spedali Civili of Brescia, Department of Medical and Surgical Specialties, Radiological Science and Public Health, University of Brescia, Brescia, Italy; Corresponding author.Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada; Division of Urology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, CanadaObjective: We performed a population-based analysis focusing on primary extranodal lymphoma of either testis, kidney, bladder or prostate (PGUL). Methods: We identified all cases of localized testis, renal, bladder and prostate primary lymphomas (PL) versus primary testis, kidney, bladder and prostate cancers within the Surveillance, Epidemiology, and End Results database (1998–2015). Estimated annual proportion change methodology (EAPC), multivariable logistic regression models, cumulative incidence plots and multivariable competing risks regression models were used. Results: The rates of testis-PL, renal-PL, bladder-PL and prostate-PL were 3.04%, 0.22%, 0.18% and 0.01%, respectively. Patients with PGUL were older and more frequently Caucasian. Annual rates significantly decreased for renal-PL (EAPC: −5.6%; p=0.004) and prostate-PL (EAPC: −3.6%; p=0.03). In multivariable logistic regression models, older ager independently predicted testis-PL (odds ratio [OR]: 16.4; p<0.001) and renal-PL (OR: 3.5; p<0.001), while female gender independently predicted bladder-PL (OR: 5.5; p<0.001). In surgically treated patients, cumulative incidence plots showed significantly higher 10-year cancer-specific mortality (CSM) rates for testis-PL, renal-PL and prostate-PL versus their primary genitourinary tumors. In multivariable competing risks regression models, only testis-PL (hazard ratio [HR]: 16.7; p<0.001) and renal-PL (HR: 2.52; p<0.001) independently predicted higher CSM rates. Conclusion: PGUL rates are extremely low and on the decrease in kidney and prostate but stable in testis and bladder. Relative to primary genitourinary tumors, PGUL are associated with worse CSM for testis-PL and renal-PL but not for bladder-PL and prostate-PL, even after adjustment for other-cause mortality.http://www.sciencedirect.com/science/article/pii/S2214388219301122Bladder lymphomaGenitourinary neoplasmGenitourinaryPrimary extranodal lymphomaProstate lymphomaRenal lymphoma |
| spellingShingle | Carlotta Palumbo Elio Mazzone Francesco A. Mistretta Sophie Knipper Zhe Tian Paul Perrotte Francesco Montorsi Shahrokh F. Shariat Fred Saad Claudio Simeone Alberto Briganti Alessandro Antonelli Pierre I. Karakiewicz Primary lymphomas of the genitourinary tract: A population-based study Asian Journal of Urology Bladder lymphoma Genitourinary neoplasm Genitourinary Primary extranodal lymphoma Prostate lymphoma Renal lymphoma |
| title | Primary lymphomas of the genitourinary tract: A population-based study |
| title_full | Primary lymphomas of the genitourinary tract: A population-based study |
| title_fullStr | Primary lymphomas of the genitourinary tract: A population-based study |
| title_full_unstemmed | Primary lymphomas of the genitourinary tract: A population-based study |
| title_short | Primary lymphomas of the genitourinary tract: A population-based study |
| title_sort | primary lymphomas of the genitourinary tract a population based study |
| topic | Bladder lymphoma Genitourinary neoplasm Genitourinary Primary extranodal lymphoma Prostate lymphoma Renal lymphoma |
| url | http://www.sciencedirect.com/science/article/pii/S2214388219301122 |
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