A Case of Metastatic Adamantinoma That Responded Well to Sunitinib
Adamantinoma is a rare low-grade malignant bone tumor of epithelial origin. Metastatic adamantinoma has been reported to be resistant to chemotherapy. We report a case of metastatic adamantinoma to the lung, 10 years after the initial diagnosis of tibial mass. The patient received radiation therapy...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/5982313 |
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| author | Andrew D. Liman Agnes K. Liman Jenna Shields Becky Englert Rashmikant Shah |
| author_facet | Andrew D. Liman Agnes K. Liman Jenna Shields Becky Englert Rashmikant Shah |
| author_sort | Andrew D. Liman |
| collection | DOAJ |
| description | Adamantinoma is a rare low-grade malignant bone tumor of epithelial origin. Metastatic adamantinoma has been reported to be resistant to chemotherapy. We report a case of metastatic adamantinoma to the lung, 10 years after the initial diagnosis of tibial mass. The patient received radiation therapy to the lung with partial response. A surveillance PET scan revealed progression of the lung mass and biopsy confirmed to be progressive residual metastatic adamantinoma. He received carboplatin and etoposide for 7 months and achieved a partial response. Four months later, PET scan showed disease progression. We started him on sunitinib, a multikinase inhibitor. He achieved a good partial response for 3 years. He died due to pneumonia at the age of 72. |
| format | Article |
| id | doaj-art-586e39823ef34811ae7ae45125bfd227 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-586e39823ef34811ae7ae45125bfd2272025-02-03T06:04:47ZengWileyCase Reports in Oncological Medicine2090-67062090-67142016-01-01201610.1155/2016/59823135982313A Case of Metastatic Adamantinoma That Responded Well to SunitinibAndrew D. Liman0Agnes K. Liman1Jenna Shields2Becky Englert3Rashmikant Shah4Hematology and Oncology, VA Pittsburgh Healthcare System, University of Pittsburgh School of Medicine, Pittsburgh, PA 15240, USAPathology, VA Pittsburgh Healthcare System, University of Pittsburgh School of Medicine, Pittsburgh, PA 15240, USAPharmacy, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USAHematology and Oncology, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USARadiology, VA Pittsburgh Healthcare System, University of Pittsburgh School of Medicine, Pittsburgh, PA 15240, USAAdamantinoma is a rare low-grade malignant bone tumor of epithelial origin. Metastatic adamantinoma has been reported to be resistant to chemotherapy. We report a case of metastatic adamantinoma to the lung, 10 years after the initial diagnosis of tibial mass. The patient received radiation therapy to the lung with partial response. A surveillance PET scan revealed progression of the lung mass and biopsy confirmed to be progressive residual metastatic adamantinoma. He received carboplatin and etoposide for 7 months and achieved a partial response. Four months later, PET scan showed disease progression. We started him on sunitinib, a multikinase inhibitor. He achieved a good partial response for 3 years. He died due to pneumonia at the age of 72.http://dx.doi.org/10.1155/2016/5982313 |
| spellingShingle | Andrew D. Liman Agnes K. Liman Jenna Shields Becky Englert Rashmikant Shah A Case of Metastatic Adamantinoma That Responded Well to Sunitinib Case Reports in Oncological Medicine |
| title | A Case of Metastatic Adamantinoma That Responded Well to Sunitinib |
| title_full | A Case of Metastatic Adamantinoma That Responded Well to Sunitinib |
| title_fullStr | A Case of Metastatic Adamantinoma That Responded Well to Sunitinib |
| title_full_unstemmed | A Case of Metastatic Adamantinoma That Responded Well to Sunitinib |
| title_short | A Case of Metastatic Adamantinoma That Responded Well to Sunitinib |
| title_sort | case of metastatic adamantinoma that responded well to sunitinib |
| url | http://dx.doi.org/10.1155/2016/5982313 |
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