Impact of MenAfriVac on Meningococcal A Meningitis in Cameroon: A Retrospective Study Using Case-by-Case-Based Surveillance Data from 2009 to 2015
Meningococcal meningitis is a public health concern in Africa. Conjugated vaccine against serogroup A Neisseria meningitidis (MenAfriVac) was used in mass vaccination and was proved to have a good impact in the meningitis belt. There is a lack of information about the impact of this intervention in...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2021/4314892 |
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| author | Bouba Gake Bonaventure Babinne Graobe Bouba Abdouraman Crescence Satou Ngah Ahmadou Aissatou Nelly-Michèle Gake Elise Claudine Seukap Elias Nchiwan Nukenine Alain G. Etoundi Mballa Marie-Christine Fonkoua Jean-Pierre Lombart |
| author_facet | Bouba Gake Bonaventure Babinne Graobe Bouba Abdouraman Crescence Satou Ngah Ahmadou Aissatou Nelly-Michèle Gake Elise Claudine Seukap Elias Nchiwan Nukenine Alain G. Etoundi Mballa Marie-Christine Fonkoua Jean-Pierre Lombart |
| author_sort | Bouba Gake |
| collection | DOAJ |
| description | Meningococcal meningitis is a public health concern in Africa. Conjugated vaccine against serogroup A Neisseria meningitidis (MenAfriVac) was used in mass vaccination and was proved to have a good impact in the meningitis belt. There is a lack of information about the impact of this intervention in Cameroon after mass vaccination was undertaken. This study aimed at filling the gap in its unknown impact in Cameroon. A retrospective longitudinal study using biological monitoring data of case-by-case-based surveillance for meningitis was obtained from the National Reference Laboratories from 1 January 2009 to 20 September 2015. Immunization coverage data were obtained from Regional Public Health Delegations where immunizations took place. We compared the risks of vaccine serogroup occurrence before and after vaccinations and calculated the global impact using Halloran’s formula. Annual cases of meningitis A decreased gradually from 92 in 2011 to 34 in 2012 and then to 1 case in 2013, and since 2014, no cases have been detected. The impact was estimated at 14.48% (p=0.41) in 2012 and then at 98.63% (p<0.0001) after the end of vaccinations in 2013. This survey confirms the effectiveness of the MenAfriVac vaccine in Cameroon as expected by the WHO. The surveillance must be pursued and enhanced to monitor coming immunizations measures with multivalent conjugated vaccines for this changing threat. |
| format | Article |
| id | doaj-art-586d74e38475409b941d53a1b90e5ae4 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-586d74e38475409b941d53a1b90e5ae42025-08-20T03:33:36ZengWileyJournal of Tropical Medicine1687-96861687-96942021-01-01202110.1155/2021/43148924314892Impact of MenAfriVac on Meningococcal A Meningitis in Cameroon: A Retrospective Study Using Case-by-Case-Based Surveillance Data from 2009 to 2015Bouba Gake0Bonaventure Babinne Graobe1Bouba Abdouraman2Crescence Satou Ngah3Ahmadou Aissatou4Nelly-Michèle Gake5Elise Claudine Seukap6Elias Nchiwan Nukenine7Alain G. Etoundi Mballa8Marie-Christine Fonkoua9Jean-Pierre Lombart10Centre Pasteur du Cameroun Annexe de Garoua, Garoua, CameroonHigher Institute of Sciences, Health Technics and Management of Garoua, Garoua, CameroonMinistry of Research and Innovation Technology, Yaoundé, CameroonFaculty of Science, University of Ngaoundere, Ngaoundere, CameroonFaculty of Science, University of Ngaoundere, Ngaoundere, CameroonCentre Pasteur du Cameroun Annexe de Garoua, Garoua, CameroonDepartment of Disease Control, Epidemics and Pandemics, Ministry of Public Health, Yaounde, CameroonFaculty of Science, University of Ngaoundere, Ngaoundere, CameroonDepartment of Disease Control, Epidemics and Pandemics, Ministry of Public Health, Yaounde, CameroonCentre Pasteur du Cameroun, Yaounde, CameroonCentre Pasteur du Cameroun Annexe de Garoua, Garoua, CameroonMeningococcal meningitis is a public health concern in Africa. Conjugated vaccine against serogroup A Neisseria meningitidis (MenAfriVac) was used in mass vaccination and was proved to have a good impact in the meningitis belt. There is a lack of information about the impact of this intervention in Cameroon after mass vaccination was undertaken. This study aimed at filling the gap in its unknown impact in Cameroon. A retrospective longitudinal study using biological monitoring data of case-by-case-based surveillance for meningitis was obtained from the National Reference Laboratories from 1 January 2009 to 20 September 2015. Immunization coverage data were obtained from Regional Public Health Delegations where immunizations took place. We compared the risks of vaccine serogroup occurrence before and after vaccinations and calculated the global impact using Halloran’s formula. Annual cases of meningitis A decreased gradually from 92 in 2011 to 34 in 2012 and then to 1 case in 2013, and since 2014, no cases have been detected. The impact was estimated at 14.48% (p=0.41) in 2012 and then at 98.63% (p<0.0001) after the end of vaccinations in 2013. This survey confirms the effectiveness of the MenAfriVac vaccine in Cameroon as expected by the WHO. The surveillance must be pursued and enhanced to monitor coming immunizations measures with multivalent conjugated vaccines for this changing threat.http://dx.doi.org/10.1155/2021/4314892 |
| spellingShingle | Bouba Gake Bonaventure Babinne Graobe Bouba Abdouraman Crescence Satou Ngah Ahmadou Aissatou Nelly-Michèle Gake Elise Claudine Seukap Elias Nchiwan Nukenine Alain G. Etoundi Mballa Marie-Christine Fonkoua Jean-Pierre Lombart Impact of MenAfriVac on Meningococcal A Meningitis in Cameroon: A Retrospective Study Using Case-by-Case-Based Surveillance Data from 2009 to 2015 Journal of Tropical Medicine |
| title | Impact of MenAfriVac on Meningococcal A Meningitis in Cameroon: A Retrospective Study Using Case-by-Case-Based Surveillance Data from 2009 to 2015 |
| title_full | Impact of MenAfriVac on Meningococcal A Meningitis in Cameroon: A Retrospective Study Using Case-by-Case-Based Surveillance Data from 2009 to 2015 |
| title_fullStr | Impact of MenAfriVac on Meningococcal A Meningitis in Cameroon: A Retrospective Study Using Case-by-Case-Based Surveillance Data from 2009 to 2015 |
| title_full_unstemmed | Impact of MenAfriVac on Meningococcal A Meningitis in Cameroon: A Retrospective Study Using Case-by-Case-Based Surveillance Data from 2009 to 2015 |
| title_short | Impact of MenAfriVac on Meningococcal A Meningitis in Cameroon: A Retrospective Study Using Case-by-Case-Based Surveillance Data from 2009 to 2015 |
| title_sort | impact of menafrivac on meningococcal a meningitis in cameroon a retrospective study using case by case based surveillance data from 2009 to 2015 |
| url | http://dx.doi.org/10.1155/2021/4314892 |
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