COMSUC: A web server for the identification of consensus molecular subtypes of cancer based on multiple methods and multi-omics data.
Extensive amounts of multi-omics data and multiple cancer subtyping methods have been developed rapidly, and generate discrepant clustering results, which poses challenges for cancer molecular subtype research. Thus, the development of methods for the identification of cancer consensus molecular sub...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-03-01
|
| Series: | PLoS Computational Biology |
| Online Access: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008769&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850046322392956928 |
|---|---|
| author | Song He Xinyu Song Xiaoxi Yang Jijun Yu Yuqi Wen Lianlian Wu Bowei Yan Jiannan Feng Xiaochen Bo |
| author_facet | Song He Xinyu Song Xiaoxi Yang Jijun Yu Yuqi Wen Lianlian Wu Bowei Yan Jiannan Feng Xiaochen Bo |
| author_sort | Song He |
| collection | DOAJ |
| description | Extensive amounts of multi-omics data and multiple cancer subtyping methods have been developed rapidly, and generate discrepant clustering results, which poses challenges for cancer molecular subtype research. Thus, the development of methods for the identification of cancer consensus molecular subtypes is essential. The lack of intuitive and easy-to-use analytical tools has posed a barrier. Here, we report on the development of the COnsensus Molecular SUbtype of Cancer (COMSUC) web server. With COMSUC, users can explore consensus molecular subtypes of more than 30 cancers based on eight clustering methods, five types of omics data from public reference datasets or users' private data, and three consensus clustering methods. The web server provides interactive and modifiable visualization, and publishable output of analysis results. Researchers can also exchange consensus subtype results with collaborators via project IDs. COMSUC is now publicly and freely available with no login requirement at http://comsuc.bioinforai.tech/ (IP address: http://59.110.25.27/). For a video summary of this web server, see S1 Video and S1 File. |
| format | Article |
| id | doaj-art-586d40bc9b5a4d3a94c0f3e5c28986cb |
| institution | DOAJ |
| issn | 1553-734X 1553-7358 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj-art-586d40bc9b5a4d3a94c0f3e5c28986cb2025-08-20T02:54:29ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582021-03-01173e100876910.1371/journal.pcbi.1008769COMSUC: A web server for the identification of consensus molecular subtypes of cancer based on multiple methods and multi-omics data.Song HeXinyu SongXiaoxi YangJijun YuYuqi WenLianlian WuBowei YanJiannan FengXiaochen BoExtensive amounts of multi-omics data and multiple cancer subtyping methods have been developed rapidly, and generate discrepant clustering results, which poses challenges for cancer molecular subtype research. Thus, the development of methods for the identification of cancer consensus molecular subtypes is essential. The lack of intuitive and easy-to-use analytical tools has posed a barrier. Here, we report on the development of the COnsensus Molecular SUbtype of Cancer (COMSUC) web server. With COMSUC, users can explore consensus molecular subtypes of more than 30 cancers based on eight clustering methods, five types of omics data from public reference datasets or users' private data, and three consensus clustering methods. The web server provides interactive and modifiable visualization, and publishable output of analysis results. Researchers can also exchange consensus subtype results with collaborators via project IDs. COMSUC is now publicly and freely available with no login requirement at http://comsuc.bioinforai.tech/ (IP address: http://59.110.25.27/). For a video summary of this web server, see S1 Video and S1 File.https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008769&type=printable |
| spellingShingle | Song He Xinyu Song Xiaoxi Yang Jijun Yu Yuqi Wen Lianlian Wu Bowei Yan Jiannan Feng Xiaochen Bo COMSUC: A web server for the identification of consensus molecular subtypes of cancer based on multiple methods and multi-omics data. PLoS Computational Biology |
| title | COMSUC: A web server for the identification of consensus molecular subtypes of cancer based on multiple methods and multi-omics data. |
| title_full | COMSUC: A web server for the identification of consensus molecular subtypes of cancer based on multiple methods and multi-omics data. |
| title_fullStr | COMSUC: A web server for the identification of consensus molecular subtypes of cancer based on multiple methods and multi-omics data. |
| title_full_unstemmed | COMSUC: A web server for the identification of consensus molecular subtypes of cancer based on multiple methods and multi-omics data. |
| title_short | COMSUC: A web server for the identification of consensus molecular subtypes of cancer based on multiple methods and multi-omics data. |
| title_sort | comsuc a web server for the identification of consensus molecular subtypes of cancer based on multiple methods and multi omics data |
| url | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008769&type=printable |
| work_keys_str_mv | AT songhe comsucawebserverfortheidentificationofconsensusmolecularsubtypesofcancerbasedonmultiplemethodsandmultiomicsdata AT xinyusong comsucawebserverfortheidentificationofconsensusmolecularsubtypesofcancerbasedonmultiplemethodsandmultiomicsdata AT xiaoxiyang comsucawebserverfortheidentificationofconsensusmolecularsubtypesofcancerbasedonmultiplemethodsandmultiomicsdata AT jijunyu comsucawebserverfortheidentificationofconsensusmolecularsubtypesofcancerbasedonmultiplemethodsandmultiomicsdata AT yuqiwen comsucawebserverfortheidentificationofconsensusmolecularsubtypesofcancerbasedonmultiplemethodsandmultiomicsdata AT lianlianwu comsucawebserverfortheidentificationofconsensusmolecularsubtypesofcancerbasedonmultiplemethodsandmultiomicsdata AT boweiyan comsucawebserverfortheidentificationofconsensusmolecularsubtypesofcancerbasedonmultiplemethodsandmultiomicsdata AT jiannanfeng comsucawebserverfortheidentificationofconsensusmolecularsubtypesofcancerbasedonmultiplemethodsandmultiomicsdata AT xiaochenbo comsucawebserverfortheidentificationofconsensusmolecularsubtypesofcancerbasedonmultiplemethodsandmultiomicsdata |