Cancer and One Health: tumor-bearing individuals can act as super spreaders of symbionts in communities
Abstract Recent theoretical advances in the One Health approach have suggested that cancer pathologies should be given greater consideration, as cancers often render their hosts more vulnerable to infectious agents, which could turn them into super spreaders within ecosystems. Although biologically...
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Nature Portfolio
2024-09-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-72171-y |
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| author | Sophie Tissot Jordan Meliani Matthew Chee Aurora M. Nedelcu Justine Boutry Jácint Tökölyi Rodrigo Hamede Benjamin Roche Beata Ujvari Frédéric Thomas Antoine M. Dujon |
| author_facet | Sophie Tissot Jordan Meliani Matthew Chee Aurora M. Nedelcu Justine Boutry Jácint Tökölyi Rodrigo Hamede Benjamin Roche Beata Ujvari Frédéric Thomas Antoine M. Dujon |
| author_sort | Sophie Tissot |
| collection | DOAJ |
| description | Abstract Recent theoretical advances in the One Health approach have suggested that cancer pathologies should be given greater consideration, as cancers often render their hosts more vulnerable to infectious agents, which could turn them into super spreaders within ecosystems. Although biologically plausible, this hypothesis has not yet been validated experimentally. Using a community of cnidarians of the Hydra genus (Hydra oligactis, Hydra viridissima, Hydra vulgaris) and a commensal ciliate species (Kerona pediculus) that colonizes them, we tested whether tumoral polyps of H. oligactis, compared to healthy ones, played an amplifying role in the number of ciliates, potentially resulting in a higher likelihood of infection for other community members through spillovers. Our results indicate that K. pediculus has a higher proliferation rate on tumoral polyps of H. oligactis than on healthy ones, which results in the infestation of other hydras. However, the magnitude of the spillover differed between recipient species. This study provides to our knowledge the first elements of proof of concept that tumoral individuals in communities could act as super spreaders of symbionts within and between species, and thus affect biotic interactions and dynamics in ecosystems. |
| format | Article |
| id | doaj-art-586d2919e7bf4d62a3eca1ddbddb6b55 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-586d2919e7bf4d62a3eca1ddbddb6b552025-08-20T02:13:14ZengNature PortfolioScientific Reports2045-23222024-09-011411710.1038/s41598-024-72171-yCancer and One Health: tumor-bearing individuals can act as super spreaders of symbionts in communitiesSophie Tissot0Jordan Meliani1Matthew Chee2Aurora M. Nedelcu3Justine Boutry4Jácint Tökölyi5Rodrigo Hamede6Benjamin Roche7Beata Ujvari8Frédéric Thomas9Antoine M. Dujon10CREEC/MIVEGEC, Université de Montpellier, CNRS, IRDCREEC/MIVEGEC, Université de Montpellier, CNRS, IRDCREEC/MIVEGEC, Université de Montpellier, CNRS, IRDDepartment of Biology, University of New BrunswickCREEC/MIVEGEC, Université de Montpellier, CNRS, IRDMTA-DE “Momentum” Ecology, Evolution and Developmental Biology Research Group, Department of Evolutionary Zoology, University of DebrecenSchool of Natural Sciences, University of TasmaniaCREEC/MIVEGEC, Université de Montpellier, CNRS, IRDSchool of Life and Environmental Sciences, Deakin UniversityCREEC/MIVEGEC, Université de Montpellier, CNRS, IRDCREEC/MIVEGEC, Université de Montpellier, CNRS, IRDAbstract Recent theoretical advances in the One Health approach have suggested that cancer pathologies should be given greater consideration, as cancers often render their hosts more vulnerable to infectious agents, which could turn them into super spreaders within ecosystems. Although biologically plausible, this hypothesis has not yet been validated experimentally. Using a community of cnidarians of the Hydra genus (Hydra oligactis, Hydra viridissima, Hydra vulgaris) and a commensal ciliate species (Kerona pediculus) that colonizes them, we tested whether tumoral polyps of H. oligactis, compared to healthy ones, played an amplifying role in the number of ciliates, potentially resulting in a higher likelihood of infection for other community members through spillovers. Our results indicate that K. pediculus has a higher proliferation rate on tumoral polyps of H. oligactis than on healthy ones, which results in the infestation of other hydras. However, the magnitude of the spillover differed between recipient species. This study provides to our knowledge the first elements of proof of concept that tumoral individuals in communities could act as super spreaders of symbionts within and between species, and thus affect biotic interactions and dynamics in ecosystems.https://doi.org/10.1038/s41598-024-72171-yNeoplasmBiotic interactionsEcologyOutbreaksEmerging diseases |
| spellingShingle | Sophie Tissot Jordan Meliani Matthew Chee Aurora M. Nedelcu Justine Boutry Jácint Tökölyi Rodrigo Hamede Benjamin Roche Beata Ujvari Frédéric Thomas Antoine M. Dujon Cancer and One Health: tumor-bearing individuals can act as super spreaders of symbionts in communities Scientific Reports Neoplasm Biotic interactions Ecology Outbreaks Emerging diseases |
| title | Cancer and One Health: tumor-bearing individuals can act as super spreaders of symbionts in communities |
| title_full | Cancer and One Health: tumor-bearing individuals can act as super spreaders of symbionts in communities |
| title_fullStr | Cancer and One Health: tumor-bearing individuals can act as super spreaders of symbionts in communities |
| title_full_unstemmed | Cancer and One Health: tumor-bearing individuals can act as super spreaders of symbionts in communities |
| title_short | Cancer and One Health: tumor-bearing individuals can act as super spreaders of symbionts in communities |
| title_sort | cancer and one health tumor bearing individuals can act as super spreaders of symbionts in communities |
| topic | Neoplasm Biotic interactions Ecology Outbreaks Emerging diseases |
| url | https://doi.org/10.1038/s41598-024-72171-y |
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