Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment
Siyu Wu,1,* Yumeng Hu,1,* Bowen Sui2 1Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China; 2First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China*These authors contributed equally to this workCor...
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| Language: | English |
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Dove Medical Press
2025-02-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/promotion-mechanisms-of-stromal-cell-mediated-lung-cancer-development--peer-reviewed-fulltext-article-CMAR |
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| author | Wu S Hu Y Sui B |
| author_facet | Wu S Hu Y Sui B |
| author_sort | Wu S |
| collection | DOAJ |
| description | Siyu Wu,1,* Yumeng Hu,1,* Bowen Sui2 1Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China; 2First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bowen Sui, Email suibowen79@126.comAbstract: Lung cancer, with its high incidence and mortality rates, has garnered significant attention in the medical community. The tumor microenvironment (TME), composed of tumor cells, stromal cells, extracellular matrix, surrounding blood vessels, and other signaling molecules, plays a pivotal role in the development of lung cancer. Stromal cells within the TME hold potential as therapeutic targets for lung cancer treatment. However, the precise and comprehensive mechanisms by which stromal cells contribute to lung cancer progression have not been fully elucidated. This review aims to explore the mechanisms through which stromal cells in the tumor microenvironment promote lung cancer development, with a particular focus on how immune cells, tumor-associated fibroblasts, and endothelial cells contribute to immune suppression, inflammation, and angiogenesis. The goal is to provide new insights and potential strategies for the diagnosis and treatment of lung cancer.Keywords: tumor microenvironment, lung cancer, stromal cells, immune cells, cancer-associated fibroblasts, endothelial cells |
| format | Article |
| id | doaj-art-5868c34f08944729a7bbcde6d02c9513 |
| institution | Kabale University |
| issn | 1179-1322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj-art-5868c34f08944729a7bbcde6d02c95132025-02-11T17:30:56ZengDove Medical PressCancer Management and Research1179-13222025-02-01Volume 17249266100043Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor MicroenvironmentWu SHu YSui BSiyu Wu,1,* Yumeng Hu,1,* Bowen Sui2 1Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China; 2First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bowen Sui, Email suibowen79@126.comAbstract: Lung cancer, with its high incidence and mortality rates, has garnered significant attention in the medical community. The tumor microenvironment (TME), composed of tumor cells, stromal cells, extracellular matrix, surrounding blood vessels, and other signaling molecules, plays a pivotal role in the development of lung cancer. Stromal cells within the TME hold potential as therapeutic targets for lung cancer treatment. However, the precise and comprehensive mechanisms by which stromal cells contribute to lung cancer progression have not been fully elucidated. This review aims to explore the mechanisms through which stromal cells in the tumor microenvironment promote lung cancer development, with a particular focus on how immune cells, tumor-associated fibroblasts, and endothelial cells contribute to immune suppression, inflammation, and angiogenesis. The goal is to provide new insights and potential strategies for the diagnosis and treatment of lung cancer.Keywords: tumor microenvironment, lung cancer, stromal cells, immune cells, cancer-associated fibroblasts, endothelial cellshttps://www.dovepress.com/promotion-mechanisms-of-stromal-cell-mediated-lung-cancer-development--peer-reviewed-fulltext-article-CMARtumor microenvironmentlung cancerstromal cellsimmune cellscancer-associated fibroblastsendothelial cells |
| spellingShingle | Wu S Hu Y Sui B Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment Cancer Management and Research tumor microenvironment lung cancer stromal cells immune cells cancer-associated fibroblasts endothelial cells |
| title | Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment |
| title_full | Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment |
| title_fullStr | Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment |
| title_full_unstemmed | Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment |
| title_short | Promotion Mechanisms of Stromal Cell-Mediated Lung Cancer Development Within Tumor Microenvironment |
| title_sort | promotion mechanisms of stromal cell mediated lung cancer development within tumor microenvironment |
| topic | tumor microenvironment lung cancer stromal cells immune cells cancer-associated fibroblasts endothelial cells |
| url | https://www.dovepress.com/promotion-mechanisms-of-stromal-cell-mediated-lung-cancer-development--peer-reviewed-fulltext-article-CMAR |
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