Lanatoside C activates the E3 ligase STUB1 to inhibit FOXP3 transcriptional activity and promote antitumor immunity

Lanatoside C activates the E3 ligase STUB1 to inhibit FOXP3 transcriptional activity and promote antitumor immunity

Abstract Regulatory T cells (Tregs) play critical roles in inhibiting antitumor immunity, which is dependent on FOXP3-mediated transcriptional activity. However, no Treg-specific therapeutics has been approved for clinical use. We performed a high-throughput screen of FDA-approved drugs for potentia...

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Bibliographic Details
Main Authors: Qian Zhou, Tong Yang, Xixi Yu, Bo Li, Jin Liu, Yongxin Mao, Rongxiang Guo, Zhuo Feng, Li Zhou, Guandi Zeng, Nan Li, Jinxia Liang, Lu Liu, Pengju Feng, Hong-Bing Shu, Liang Chen
Format: Article
Language:English
Published: Springer Nature 2025-02-01
Series:EMBO Molecular Medicine
Subjects:
Immunotherapy
Tumor Microenvironment
Regulatory T Cells
PD-1 Inhibitor
Online Access:https://doi.org/10.1038/s44321-025-00200-y
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