Coxsackievirus B4 (CV-B4) linked to four severe neonatal infections including one fatal, Northern Ireland, October 2024 to February 2025
We report four cases of severe neonatal non-polio enterovirus infection, requiring hospital admission. Infants presented to different regional hospitals across Northern Ireland from late 2024 to early 2025. Three had neonatal meningitis and one showed rapid demise, leading to sepsis, multi-organ fai...
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European Centre for Disease Prevention and Control
2025-05-01
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| Series: | Eurosurveillance |
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| Online Access: | https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2025.30.21.2500317 |
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| author | James P McKenna |
| author_facet | James P McKenna |
| author_sort | James P McKenna |
| collection | DOAJ |
| description | We report four cases of severe neonatal non-polio enterovirus infection, requiring hospital admission. Infants presented to different regional hospitals across Northern Ireland from late 2024 to early 2025. Three had neonatal meningitis and one showed rapid demise, leading to sepsis, multi-organ failure and death at day 6 of life. All infants were less than 18 days old at presentation, two were considered congenital infections, with one presenting symptoms at birth. All infants had detectable enterovirus RNA, typed as coxsackievirus B4. |
| format | Article |
| id | doaj-art-5863e1e34842471c8a0a8dfb6e52a0c9 |
| institution | OA Journals |
| issn | 1560-7917 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | European Centre for Disease Prevention and Control |
| record_format | Article |
| series | Eurosurveillance |
| spelling | doaj-art-5863e1e34842471c8a0a8dfb6e52a0c92025-08-20T02:05:24ZengEuropean Centre for Disease Prevention and ControlEurosurveillance1560-79172025-05-01302110.2807/1560-7917.ES.2025.30.21.2500317http://instance.metastore.ingenta.com/content/eurosurveillance/30/21Coxsackievirus B4 (CV-B4) linked to four severe neonatal infections including one fatal, Northern Ireland, October 2024 to February 2025James P McKenna0Regional Virus Laboratory, Royal Victoria Hospital, Belfast, Northern Ireland, United KingdomWe report four cases of severe neonatal non-polio enterovirus infection, requiring hospital admission. Infants presented to different regional hospitals across Northern Ireland from late 2024 to early 2025. Three had neonatal meningitis and one showed rapid demise, leading to sepsis, multi-organ failure and death at day 6 of life. All infants were less than 18 days old at presentation, two were considered congenital infections, with one presenting symptoms at birth. All infants had detectable enterovirus RNA, typed as coxsackievirus B4.https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2025.30.21.2500317notifiableenterovirus meningitisEnterovirusCV-B4congenitalneonatal sepsis |
| spellingShingle | James P McKenna Coxsackievirus B4 (CV-B4) linked to four severe neonatal infections including one fatal, Northern Ireland, October 2024 to February 2025 Eurosurveillance notifiable enterovirus meningitis Enterovirus CV-B4 congenital neonatal sepsis |
| title | Coxsackievirus B4 (CV-B4) linked to four severe neonatal infections including one fatal, Northern Ireland, October 2024 to February 2025 |
| title_full | Coxsackievirus B4 (CV-B4) linked to four severe neonatal infections including one fatal, Northern Ireland, October 2024 to February 2025 |
| title_fullStr | Coxsackievirus B4 (CV-B4) linked to four severe neonatal infections including one fatal, Northern Ireland, October 2024 to February 2025 |
| title_full_unstemmed | Coxsackievirus B4 (CV-B4) linked to four severe neonatal infections including one fatal, Northern Ireland, October 2024 to February 2025 |
| title_short | Coxsackievirus B4 (CV-B4) linked to four severe neonatal infections including one fatal, Northern Ireland, October 2024 to February 2025 |
| title_sort | coxsackievirus b4 cv b4 linked to four severe neonatal infections including one fatal northern ireland october 2024 to february 2025 |
| topic | notifiable enterovirus meningitis Enterovirus CV-B4 congenital neonatal sepsis |
| url | https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2025.30.21.2500317 |
| work_keys_str_mv | AT jamespmckenna coxsackievirusb4cvb4linkedtofoursevereneonatalinfectionsincludingonefatalnorthernirelandoctober2024tofebruary2025 |