Effect of human serum albumin on clinical outcomes in pediatric patients undergoing gastrointestinal surgery
PurposeThis study aims to evaluate the effectiveness of administering 20% human serum albumin (HSA) on short-term clinical outcomes in pediatric patients undergoing enteric anastomosis, with a specific focus on postoperative hospital stay (PHS), postoperative fasting duration (PFD), and the incidenc...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1590586/full |
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| author | Ping Li Mi Zhou Da-Yu Chen Ya-Kun Liu Feng Liu Yong-Gen Xu Jian Wang Huan Gui |
| author_facet | Ping Li Mi Zhou Da-Yu Chen Ya-Kun Liu Feng Liu Yong-Gen Xu Jian Wang Huan Gui |
| author_sort | Ping Li |
| collection | DOAJ |
| description | PurposeThis study aims to evaluate the effectiveness of administering 20% human serum albumin (HSA) on short-term clinical outcomes in pediatric patients undergoing enteric anastomosis, with a specific focus on postoperative hospital stay (PHS), postoperative fasting duration (PFD), and the incidence of postoperative complications (PCs).MethodsThis was a single-center, retrospective cohort study. Patients aged between 1 month and 18 years who underwent simple intestinal anastomosis were included. Comprehensive data, including patient demographics, prescribed medications, laboratory test results, and surgical records, were meticulously extracted from electronic patient dossiers. The primary endpoint was PHS. The second endpoint included PFD and PCs. Since this was a retrospective cohort study, we used propensity score matching (PSM) to balance different variables. The efficacy of 20% HSA on clinical outcomes was assessed by univariate and multivariate logistic regression analyses.ResultsAmong a cohort of 242 patients, 67 (27.69%) were administered 20% HSA for over 2 days during the early postoperative stage. A dose-related pattern of HSA efficacy on clinical outcomes was observed in the PSM cohort. After adjustment, HSA overuse was identified as an independent risk factor for prolonged PHS and a higher complication incidence, with odds ratios of 6.56 [95% confidence interval (CI): 2.12–20.32] and 5.14 (95% CI: 1.21–21.83), respectively.ConclusionsOveruse of 20% HSA in the early postoperative stage does not contribute to improved clinical outcomes in pediatric patients undergoing gastrointestinal surgery. |
| format | Article |
| id | doaj-art-5861c97476ce458084901262cddb4ece |
| institution | DOAJ |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-5861c97476ce458084901262cddb4ece2025-08-20T02:40:21ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-07-011310.3389/fped.2025.15905861590586Effect of human serum albumin on clinical outcomes in pediatric patients undergoing gastrointestinal surgeryPing Li0Mi Zhou1Da-Yu Chen2Ya-Kun Liu3Feng Liu4Yong-Gen Xu5Jian Wang6Huan Gui7Department ofClinical Nutrition, Children’s Hospital of Soochow University, Suzhou, ChinaDepartment of Pharmacy, Children’s Hospital of Soochow University, Suzhou, ChinaDepartment of Pharmacy, Nanjing Drum Tower Hospital, Nanjing, ChinaDepartment of General Surgery, Children’s Hospital of Soochow University, Suzhou, ChinaSurgical Intensive Care Unit, Children’s Hospital of Soochow University, Suzhou, ChinaSurgical Intensive Care Unit, Children’s Hospital of Soochow University, Suzhou, ChinaDepartment of General Surgery, Children’s Hospital of Soochow University, Suzhou, ChinaDepartment of Pharmacy, Children’s Hospital of Soochow University, Suzhou, ChinaPurposeThis study aims to evaluate the effectiveness of administering 20% human serum albumin (HSA) on short-term clinical outcomes in pediatric patients undergoing enteric anastomosis, with a specific focus on postoperative hospital stay (PHS), postoperative fasting duration (PFD), and the incidence of postoperative complications (PCs).MethodsThis was a single-center, retrospective cohort study. Patients aged between 1 month and 18 years who underwent simple intestinal anastomosis were included. Comprehensive data, including patient demographics, prescribed medications, laboratory test results, and surgical records, were meticulously extracted from electronic patient dossiers. The primary endpoint was PHS. The second endpoint included PFD and PCs. Since this was a retrospective cohort study, we used propensity score matching (PSM) to balance different variables. The efficacy of 20% HSA on clinical outcomes was assessed by univariate and multivariate logistic regression analyses.ResultsAmong a cohort of 242 patients, 67 (27.69%) were administered 20% HSA for over 2 days during the early postoperative stage. A dose-related pattern of HSA efficacy on clinical outcomes was observed in the PSM cohort. After adjustment, HSA overuse was identified as an independent risk factor for prolonged PHS and a higher complication incidence, with odds ratios of 6.56 [95% confidence interval (CI): 2.12–20.32] and 5.14 (95% CI: 1.21–21.83), respectively.ConclusionsOveruse of 20% HSA in the early postoperative stage does not contribute to improved clinical outcomes in pediatric patients undergoing gastrointestinal surgery.https://www.frontiersin.org/articles/10.3389/fped.2025.1590586/fullhuman serum albuminclinical outcomepediatricsgastrointestinal surgerypropensity score matching |
| spellingShingle | Ping Li Mi Zhou Da-Yu Chen Ya-Kun Liu Feng Liu Yong-Gen Xu Jian Wang Huan Gui Effect of human serum albumin on clinical outcomes in pediatric patients undergoing gastrointestinal surgery Frontiers in Pediatrics human serum albumin clinical outcome pediatrics gastrointestinal surgery propensity score matching |
| title | Effect of human serum albumin on clinical outcomes in pediatric patients undergoing gastrointestinal surgery |
| title_full | Effect of human serum albumin on clinical outcomes in pediatric patients undergoing gastrointestinal surgery |
| title_fullStr | Effect of human serum albumin on clinical outcomes in pediatric patients undergoing gastrointestinal surgery |
| title_full_unstemmed | Effect of human serum albumin on clinical outcomes in pediatric patients undergoing gastrointestinal surgery |
| title_short | Effect of human serum albumin on clinical outcomes in pediatric patients undergoing gastrointestinal surgery |
| title_sort | effect of human serum albumin on clinical outcomes in pediatric patients undergoing gastrointestinal surgery |
| topic | human serum albumin clinical outcome pediatrics gastrointestinal surgery propensity score matching |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1590586/full |
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