Screening of 50,539 newborns for congenital hypothyroidism: optimization of TSH cut-off values and seasonal impact in clinical practice

Screening of 50,539 newborns for congenital hypothyroidism: optimization of TSH cut-off values and seasonal impact in clinical practice

ObjectiveTo analyze the incidence of congenital hypothyroidism (CH) in Putian, optimize the thyroid-stimulating hormone (TSH) screening cut-off value, and improve diagnostic efficiency and accuracy.MethodsA retrospective analysis was conducted on TSH screening data from 50,539 newborns in Putian bet...

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Bibliographic Details
Main Authors: Lixian Zhang, Kun Lin, Xinrong Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Endocrinology
Subjects:
newborn disease screening
congenital hypothyroidism
thyroid-stimulating hormone (TSH)
cut-off optimization
seasonal impact
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1616748/full
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