Transcriptomic analysis reveals shared deregulated neutrophil responses in COVID-19 and idiopathic pulmonary fibrosis

Transcriptomic analysis reveals shared deregulated neutrophil responses in COVID-19 and idiopathic pulmonary fibrosis

Abstract Background Coronavirus disease 2019 (COVID-19) is a respiratory disease linked with deregulated immune responses, leading to hyperinflammation, acute respiratory distress syndrome, and pulmonary fibrosis, often with fatal outcomes. Neutrophils play a central role in COVID-19 pathogenesis, w...

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Main Authors: Georgios Divolis, Evgenia Synolaki, Rodoula Tringidou, Argyrios Tzouvelekis, Dimitrios T. Boumpas, Panagiotis Skendros, Ioanna-Evdokia Galani
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Respiratory Research
Subjects:
Neutrophils
COVID-19
Viral infection
Idiopathic pulmonary fibrosis
NETosis
RNA Sequencing
Online Access:https://doi.org/10.1186/s12931-025-03180-2
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