Emergencies in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multi-organ involvement, characterized by periods of remission and flares. Severe disease manifestations and complications of immunosuppressive therapy are common reasons for emergency department visits. Nephrological, neurologi...
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| Format: | Article |
| Language: | English |
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Turkish Society for Rheumatology
2025-07-01
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| Series: | Ulusal Romatoloji Dergisi |
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| Online Access: | https://www.raeddergisi.org/articles/emergencies-in-systemic-lupus-erythematosus/doi/raed.galenos.2025.69672 |
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| author | Senem Tekeoğlu Gökhan Keser |
| author_facet | Senem Tekeoğlu Gökhan Keser |
| author_sort | Senem Tekeoğlu |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multi-organ involvement, characterized by periods of remission and flares. Severe disease manifestations and complications of immunosuppressive therapy are common reasons for emergency department visits. Nephrological, neurological, pulmonary, and hematological involvement may require urgent intervention. Lupus nephritis, thrombotic microangiopathy, and antiphospholipid syndrome can cause significant renal dysfunction. Neurological complications include stroke, seizures, neuropsychiatric lupus, and central nervous system vasculitis. Pulmonary emergencies such as acute lupus pneumonitis, diffuse alveolar hemorrhage, and pulmonary embolism are life-threatening, while cardiac involvement includes pericarditis, myocarditis, and accelerated atherosclerosis. Hematologic complications, including autoimmune hemolytic anemia, thrombocytopenia, and macrophage activation syndrome, are associated with high mortality. Infections are common in immunosuppressed patients and can mimic disease flares. During pregnancy, complications such as preeclampsia, Hemolysis, Elevated Liver enzymes, Low Platelets syndrome, neonatal lupus, and antiphospholipid syndrome-related thrombosis may arise. The management of SLE emergencies requires a multidisciplinary approach. Individualized treatment strategies following current guidelines and early intervention are crucial in reducing mortality. |
| format | Article |
| id | doaj-art-58574db1e79b4c2ca2b73a9de9cc60fc |
| institution | DOAJ |
| issn | 2651-2653 2651-2661 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Turkish Society for Rheumatology |
| record_format | Article |
| series | Ulusal Romatoloji Dergisi |
| spelling | doaj-art-58574db1e79b4c2ca2b73a9de9cc60fc2025-08-20T03:16:16ZengTurkish Society for RheumatologyUlusal Romatoloji Dergisi2651-26532651-26612025-07-0117212013010.4274/raed.galenos.2025.69672Emergencies in systemic lupus erythematosusSenem Tekeoğlu0https://orcid.org/0000-0001-5539-8755Gökhan Keser1https://orcid.org/0000-0001-7289-1816Haliç Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, İstanbul, TürkiyeEge Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Bilim Dalı, İzmir, TürkiyeSystemic lupus erythematosus (SLE) is a chronic autoimmune disease with multi-organ involvement, characterized by periods of remission and flares. Severe disease manifestations and complications of immunosuppressive therapy are common reasons for emergency department visits. Nephrological, neurological, pulmonary, and hematological involvement may require urgent intervention. Lupus nephritis, thrombotic microangiopathy, and antiphospholipid syndrome can cause significant renal dysfunction. Neurological complications include stroke, seizures, neuropsychiatric lupus, and central nervous system vasculitis. Pulmonary emergencies such as acute lupus pneumonitis, diffuse alveolar hemorrhage, and pulmonary embolism are life-threatening, while cardiac involvement includes pericarditis, myocarditis, and accelerated atherosclerosis. Hematologic complications, including autoimmune hemolytic anemia, thrombocytopenia, and macrophage activation syndrome, are associated with high mortality. Infections are common in immunosuppressed patients and can mimic disease flares. During pregnancy, complications such as preeclampsia, Hemolysis, Elevated Liver enzymes, Low Platelets syndrome, neonatal lupus, and antiphospholipid syndrome-related thrombosis may arise. The management of SLE emergencies requires a multidisciplinary approach. Individualized treatment strategies following current guidelines and early intervention are crucial in reducing mortality.https://www.raeddergisi.org/articles/emergencies-in-systemic-lupus-erythematosus/doi/raed.galenos.2025.69672systemic lupus erythematosusemergency treatmentmultiple organ failure |
| spellingShingle | Senem Tekeoğlu Gökhan Keser Emergencies in systemic lupus erythematosus Ulusal Romatoloji Dergisi systemic lupus erythematosus emergency treatment multiple organ failure |
| title | Emergencies in systemic lupus erythematosus |
| title_full | Emergencies in systemic lupus erythematosus |
| title_fullStr | Emergencies in systemic lupus erythematosus |
| title_full_unstemmed | Emergencies in systemic lupus erythematosus |
| title_short | Emergencies in systemic lupus erythematosus |
| title_sort | emergencies in systemic lupus erythematosus |
| topic | systemic lupus erythematosus emergency treatment multiple organ failure |
| url | https://www.raeddergisi.org/articles/emergencies-in-systemic-lupus-erythematosus/doi/raed.galenos.2025.69672 |
| work_keys_str_mv | AT senemtekeoglu emergenciesinsystemiclupuserythematosus AT gokhankeser emergenciesinsystemiclupuserythematosus |