Maternal age and the risk of fetal aneuploidy: A nationwide cohort study of more than 500 000 singleton pregnancies in Denmark from 2008 to 2017
Abstract Introduction In this register‐based study of pregnancies in Denmark, we assessed the associations between maternal age and the risk of fetal aneuploidies (trisomy 21, trisomy 18, trisomy 13, triploidy, monosomy X and other sex chromosome aberrations). Additionally, we aimed to disentangle t...
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Wiley
2024-02-01
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| Series: | Acta Obstetricia et Gynecologica Scandinavica |
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| Online Access: | https://doi.org/10.1111/aogs.14713 |
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| author | Line Elmerdahl Frederiksen Sofie Møller Ølgaard Laura Roos Olav Bjørn Petersen Line Rode Tanja Hartwig Charlotte Kvist Ekelund the Danish Central Cytogenetics Registry Study Group Ida Vogel |
| author_facet | Line Elmerdahl Frederiksen Sofie Møller Ølgaard Laura Roos Olav Bjørn Petersen Line Rode Tanja Hartwig Charlotte Kvist Ekelund the Danish Central Cytogenetics Registry Study Group Ida Vogel |
| author_sort | Line Elmerdahl Frederiksen |
| collection | DOAJ |
| description | Abstract Introduction In this register‐based study of pregnancies in Denmark, we assessed the associations between maternal age and the risk of fetal aneuploidies (trisomy 21, trisomy 18, trisomy 13, triploidy, monosomy X and other sex chromosome aberrations). Additionally, we aimed to disentangle the maternal age‐related effect on fetal aneuploidies by cases with translocation trisomies and mosaicisms. Material and methods We followed a nationwide cohort of 542 375 singleton‐pregnant women attending first trimester screening in Denmark between 2008 and 2017 until delivery, miscarriage or termination of pregnancy. We used six maternal age categories and retrieved information on genetically confirmed aneuploidies of the fetus and infant from the national cytogenetic register. Results We confirmed the known associations between advanced maternal age and higher risk of trisomy 21, 18, 13 and other sex chromosome aberrations, especially in women aged ≥35 years, whereas we found no age‐related associations with triploidy or monosomy X. Cases with translocation trisomies and mosaicisms did not influence the overall reported association between maternal age and aneuploidies. Conclusion This study provides insight into the accurate risk of fetal aneuploidies that pregnant women of advanced ages encounter. |
| format | Article |
| id | doaj-art-584d3421d0d7442e9bb3c7f44e87d839 |
| institution | OA Journals |
| issn | 0001-6349 1600-0412 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Acta Obstetricia et Gynecologica Scandinavica |
| spelling | doaj-art-584d3421d0d7442e9bb3c7f44e87d8392025-08-20T02:36:39ZengWileyActa Obstetricia et Gynecologica Scandinavica0001-63491600-04122024-02-01103235135910.1111/aogs.14713Maternal age and the risk of fetal aneuploidy: A nationwide cohort study of more than 500 000 singleton pregnancies in Denmark from 2008 to 2017Line Elmerdahl Frederiksen0Sofie Møller Ølgaard1Laura Roos2Olav Bjørn Petersen3Line Rode4Tanja Hartwig5Charlotte Kvist Ekelund6the Danish Central Cytogenetics Registry Study GroupIda Vogel7Childhood Cancer Research Group Danish Cancer Society Research Center Copenhagen DenmarkCenter For Fetal Diagnostics, Department of Clinical Medicine Aarhus University Aarhus DenmarkDepartment of Clinical Genetics Copenhagen University Hospital, Rigshospitalet Copenhagen DenmarkCenter of Fetal Medicine, Department of Obstetrics Copenhagen University Hospital, Rigshospitalet Copenhagen DenmarkCenter of Fetal Medicine, Department of Obstetrics Copenhagen University Hospital, Rigshospitalet Copenhagen DenmarkDepartment of Obstetrics and Gynecology Copenhagen University Hospital Hvidovre Hvidovre DenmarkCenter of Fetal Medicine, Department of Obstetrics Copenhagen University Hospital, Rigshospitalet Copenhagen DenmarkCenter For Fetal Diagnostics, Department of Clinical Medicine Aarhus University Aarhus DenmarkAbstract Introduction In this register‐based study of pregnancies in Denmark, we assessed the associations between maternal age and the risk of fetal aneuploidies (trisomy 21, trisomy 18, trisomy 13, triploidy, monosomy X and other sex chromosome aberrations). Additionally, we aimed to disentangle the maternal age‐related effect on fetal aneuploidies by cases with translocation trisomies and mosaicisms. Material and methods We followed a nationwide cohort of 542 375 singleton‐pregnant women attending first trimester screening in Denmark between 2008 and 2017 until delivery, miscarriage or termination of pregnancy. We used six maternal age categories and retrieved information on genetically confirmed aneuploidies of the fetus and infant from the national cytogenetic register. Results We confirmed the known associations between advanced maternal age and higher risk of trisomy 21, 18, 13 and other sex chromosome aberrations, especially in women aged ≥35 years, whereas we found no age‐related associations with triploidy or monosomy X. Cases with translocation trisomies and mosaicisms did not influence the overall reported association between maternal age and aneuploidies. Conclusion This study provides insight into the accurate risk of fetal aneuploidies that pregnant women of advanced ages encounter.https://doi.org/10.1111/aogs.14713aneuploidygenetic risk factorsmaternal agenumeric chromosomal anomaliespregnancy risksex chromosome aberrations |
| spellingShingle | Line Elmerdahl Frederiksen Sofie Møller Ølgaard Laura Roos Olav Bjørn Petersen Line Rode Tanja Hartwig Charlotte Kvist Ekelund the Danish Central Cytogenetics Registry Study Group Ida Vogel Maternal age and the risk of fetal aneuploidy: A nationwide cohort study of more than 500 000 singleton pregnancies in Denmark from 2008 to 2017 Acta Obstetricia et Gynecologica Scandinavica aneuploidy genetic risk factors maternal age numeric chromosomal anomalies pregnancy risk sex chromosome aberrations |
| title | Maternal age and the risk of fetal aneuploidy: A nationwide cohort study of more than 500 000 singleton pregnancies in Denmark from 2008 to 2017 |
| title_full | Maternal age and the risk of fetal aneuploidy: A nationwide cohort study of more than 500 000 singleton pregnancies in Denmark from 2008 to 2017 |
| title_fullStr | Maternal age and the risk of fetal aneuploidy: A nationwide cohort study of more than 500 000 singleton pregnancies in Denmark from 2008 to 2017 |
| title_full_unstemmed | Maternal age and the risk of fetal aneuploidy: A nationwide cohort study of more than 500 000 singleton pregnancies in Denmark from 2008 to 2017 |
| title_short | Maternal age and the risk of fetal aneuploidy: A nationwide cohort study of more than 500 000 singleton pregnancies in Denmark from 2008 to 2017 |
| title_sort | maternal age and the risk of fetal aneuploidy a nationwide cohort study of more than 500 000 singleton pregnancies in denmark from 2008 to 2017 |
| topic | aneuploidy genetic risk factors maternal age numeric chromosomal anomalies pregnancy risk sex chromosome aberrations |
| url | https://doi.org/10.1111/aogs.14713 |
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