Immune imbalance in Lupus Nephritis: The intersection of T-Cell and ferroptosis
Ferroptosis is a novel form of cell death characterized by unlimited accumulation of iron-dependent lipid peroxides. It is often accompanied by disease, and the relationship between ferroptosis of immune cells and immune regulation has been attracting increasing attention. Initially, it was found in...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1520570/full |
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| author | Yunhe Fan Kuai Ma Yumeng Lin Junyi Ren Haoyu Peng Lan Yuan Moussa Ide Nasser Xuan Jiang Ke Wang |
| author_facet | Yunhe Fan Kuai Ma Yumeng Lin Junyi Ren Haoyu Peng Lan Yuan Moussa Ide Nasser Xuan Jiang Ke Wang |
| author_sort | Yunhe Fan |
| collection | DOAJ |
| description | Ferroptosis is a novel form of cell death characterized by unlimited accumulation of iron-dependent lipid peroxides. It is often accompanied by disease, and the relationship between ferroptosis of immune cells and immune regulation has been attracting increasing attention. Initially, it was found in cancer research that the inhibition of regulatory T cell (Treg) ferroptosis and the promotion of CD8+ T cell ferroptosis jointly promoted the formation of an immune-tolerant environment in tumors. T-cell ferroptosis has subsequently been found to have immunoregulatory effects in other diseases. As an autoimmune disease characterized by immune imbalance, T-cell ferroptosis has attracted attention for its potential in regulating immune balance in lupus nephritis. This article reviews the metabolic processes within different T-cell subsets in lupus nephritis (LN), including T follicular helper (TFH) cells, T helper (Th)17 cells, Th1 cells, Th2 cells, and Treg cells, and reveals that these cellular metabolisms not only facilitate the formation of a T-cell immune imbalance but are also closely associated with the occurrence of ferroptosis. Consequently, we hypothesize that targeting the metabolic pathways of ferroptosis could become a novel research direction for effectively treating the immune imbalance in lupus nephritis by altering T-cell differentiation and the incidence of ferroptosis. |
| format | Article |
| id | doaj-art-5846bb18e9934e98a67bd2fde7b84af1 |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-5846bb18e9934e98a67bd2fde7b84af12025-08-20T01:58:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.15205701520570Immune imbalance in Lupus Nephritis: The intersection of T-Cell and ferroptosisYunhe Fan0Kuai Ma1Yumeng Lin2Junyi Ren3Haoyu Peng4Lan Yuan5Moussa Ide Nasser6Xuan Jiang7Ke Wang8School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Deyang Hospital Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Deyang, ChinaDepartment of Nephrology, Osaka University Graduate School of Medicine, Osaka, JapanHealth Management Center, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, ChinaUniversity of Electronic Science and Technology of China, School of Medicine, Chengdu, ChinaUniversity of Electronic Science and Technology of China, School of Medicine, Chengdu, ChinaSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Deyang Hospital Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Deyang, ChinaDepartment of Nephrology, Osaka University Graduate School of Medicine, Osaka, JapanSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Deyang Hospital Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Deyang, ChinaSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Deyang Hospital Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Deyang, ChinaFerroptosis is a novel form of cell death characterized by unlimited accumulation of iron-dependent lipid peroxides. It is often accompanied by disease, and the relationship between ferroptosis of immune cells and immune regulation has been attracting increasing attention. Initially, it was found in cancer research that the inhibition of regulatory T cell (Treg) ferroptosis and the promotion of CD8+ T cell ferroptosis jointly promoted the formation of an immune-tolerant environment in tumors. T-cell ferroptosis has subsequently been found to have immunoregulatory effects in other diseases. As an autoimmune disease characterized by immune imbalance, T-cell ferroptosis has attracted attention for its potential in regulating immune balance in lupus nephritis. This article reviews the metabolic processes within different T-cell subsets in lupus nephritis (LN), including T follicular helper (TFH) cells, T helper (Th)17 cells, Th1 cells, Th2 cells, and Treg cells, and reveals that these cellular metabolisms not only facilitate the formation of a T-cell immune imbalance but are also closely associated with the occurrence of ferroptosis. Consequently, we hypothesize that targeting the metabolic pathways of ferroptosis could become a novel research direction for effectively treating the immune imbalance in lupus nephritis by altering T-cell differentiation and the incidence of ferroptosis.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1520570/fullferroptosisT cellsLupus Nephritisimmune imbalancecellular metabolism |
| spellingShingle | Yunhe Fan Kuai Ma Yumeng Lin Junyi Ren Haoyu Peng Lan Yuan Moussa Ide Nasser Xuan Jiang Ke Wang Immune imbalance in Lupus Nephritis: The intersection of T-Cell and ferroptosis Frontiers in Immunology ferroptosis T cells Lupus Nephritis immune imbalance cellular metabolism |
| title | Immune imbalance in Lupus Nephritis: The intersection of T-Cell and ferroptosis |
| title_full | Immune imbalance in Lupus Nephritis: The intersection of T-Cell and ferroptosis |
| title_fullStr | Immune imbalance in Lupus Nephritis: The intersection of T-Cell and ferroptosis |
| title_full_unstemmed | Immune imbalance in Lupus Nephritis: The intersection of T-Cell and ferroptosis |
| title_short | Immune imbalance in Lupus Nephritis: The intersection of T-Cell and ferroptosis |
| title_sort | immune imbalance in lupus nephritis the intersection of t cell and ferroptosis |
| topic | ferroptosis T cells Lupus Nephritis immune imbalance cellular metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1520570/full |
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