Synthesis and Characterization of new Mannich Bases for Pyrazole containing Benimidazole Ring
This research includes synthesis of new derivatives of benzimidazole , the compound (A1*) prepared by reaction of o-phenylene diamine with carbon disulfide in alcoholic potassium hydroxide. Then the compound (A1*) was reaction with ethyl chloroacetate and potassium hydroxide to give ester (A2*). Th...
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| Format: | Article |
| Language: | English |
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Tikrit University
2023-01-01
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| Series: | Tikrit Journal of Pure Science |
| Subjects: | |
| Online Access: | https://tjpsj.org/index.php/tjps/article/view/592 |
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| _version_ | 1849426841669992448 |
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| author | Aya H. Mohammed Ahmed A. H. Al-Kadhimi Fadhel D. Khaled |
| author_facet | Aya H. Mohammed Ahmed A. H. Al-Kadhimi Fadhel D. Khaled |
| author_sort | Aya H. Mohammed |
| collection | DOAJ |
| description |
This research includes synthesis of new derivatives of benzimidazole , the compound (A1*) prepared by reaction of o-phenylene diamine with carbon disulfide in alcoholic potassium hydroxide. Then the compound (A1*) was reaction with ethyl chloroacetate and potassium hydroxide to give ester (A2*). Then preparation of hydrazide (A3*) by the reaction of (A2*) with hydrazine hydrate (80%). Then we used the hydrazide (A3*) to prepare pyrazole (A4), then preparation of mannich basses by reaction of compound (A4) with different primary aromatic amines and formaldehyde
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| format | Article |
| id | doaj-art-5843620ea5df46c3975dc2d9b5be8271 |
| institution | Kabale University |
| issn | 1813-1662 2415-1726 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Tikrit University |
| record_format | Article |
| series | Tikrit Journal of Pure Science |
| spelling | doaj-art-5843620ea5df46c3975dc2d9b5be82712025-08-20T03:29:14ZengTikrit UniversityTikrit Journal of Pure Science1813-16622415-17262023-01-0123510.25130/tjps.v23i5.592Synthesis and Characterization of new Mannich Bases for Pyrazole containing Benimidazole RingAya H. MohammedAhmed A. H. Al-KadhimiFadhel D. Khaled This research includes synthesis of new derivatives of benzimidazole , the compound (A1*) prepared by reaction of o-phenylene diamine with carbon disulfide in alcoholic potassium hydroxide. Then the compound (A1*) was reaction with ethyl chloroacetate and potassium hydroxide to give ester (A2*). Then preparation of hydrazide (A3*) by the reaction of (A2*) with hydrazine hydrate (80%). Then we used the hydrazide (A3*) to prepare pyrazole (A4), then preparation of mannich basses by reaction of compound (A4) with different primary aromatic amines and formaldehyde https://tjpsj.org/index.php/tjps/article/view/592BenzimidazolePyrazoleMannich Basses |
| spellingShingle | Aya H. Mohammed Ahmed A. H. Al-Kadhimi Fadhel D. Khaled Synthesis and Characterization of new Mannich Bases for Pyrazole containing Benimidazole Ring Tikrit Journal of Pure Science Benzimidazole Pyrazole Mannich Basses |
| title | Synthesis and Characterization of new Mannich Bases for Pyrazole containing Benimidazole Ring |
| title_full | Synthesis and Characterization of new Mannich Bases for Pyrazole containing Benimidazole Ring |
| title_fullStr | Synthesis and Characterization of new Mannich Bases for Pyrazole containing Benimidazole Ring |
| title_full_unstemmed | Synthesis and Characterization of new Mannich Bases for Pyrazole containing Benimidazole Ring |
| title_short | Synthesis and Characterization of new Mannich Bases for Pyrazole containing Benimidazole Ring |
| title_sort | synthesis and characterization of new mannich bases for pyrazole containing benimidazole ring |
| topic | Benzimidazole Pyrazole Mannich Basses |
| url | https://tjpsj.org/index.php/tjps/article/view/592 |
| work_keys_str_mv | AT ayahmohammed synthesisandcharacterizationofnewmannichbasesforpyrazolecontainingbenimidazolering AT ahmedahalkadhimi synthesisandcharacterizationofnewmannichbasesforpyrazolecontainingbenimidazolering AT fadheldkhaled synthesisandcharacterizationofnewmannichbasesforpyrazolecontainingbenimidazolering |