Metformin may alter the course of Leber’s hereditary optic neuropathy: a case report

Metformin may alter the course of Leber’s hereditary optic neuropathy: a case report

Leber’s hereditary optic neuropathy (LHON) is a rare inherited mitochondrial disease caused by variants in mitochondrial DNA (mtDNA) transmitted exclusively through the maternal line. The disease predominantly affects young males and is characterized by progressive bilateral vision loss. Idebenone,...

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Bibliographic Details
Main Authors: Shenoda Abd Elmaseh, Danielle A. Gauthier, Maryam Golmohammadi, Nutsa Pargalava, Valerio Carelli, Alfredo A. Sadun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Medicine
Subjects:
metformin
LHON
idebenone
NAD+
vision Loss
mitochondrial dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1609941/full
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