Enhancing Proton Therapy Efficacy Through Nanoparticle-Mediated Radiosensitization
Proton therapy, characterized by its unique Bragg peak, offers the potential to optimize the destruction of cancer cells while sparing healthy tissues, positioning it as one of the most advanced cancer treatment modalities currently available. However, in comparison to heavy ions, protons exhibit a...
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MDPI AG
2024-11-01
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| Online Access: | https://www.mdpi.com/2073-4409/13/22/1841 |
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| author | Jie Ma Hao Shen Zhaohong Mi |
| author_facet | Jie Ma Hao Shen Zhaohong Mi |
| author_sort | Jie Ma |
| collection | DOAJ |
| description | Proton therapy, characterized by its unique Bragg peak, offers the potential to optimize the destruction of cancer cells while sparing healthy tissues, positioning it as one of the most advanced cancer treatment modalities currently available. However, in comparison to heavy ions, protons exhibit a relatively lower relative biological effectiveness (RBE), which limits the efficacy of proton therapy. The incorporation of nanoparticles for radiosensitization presents a novel approach to enhance the RBE of protons. This review provides a comprehensive discussion of the recent advancements in augmenting the biological effects of proton therapy through the use of nanoparticles. It examines the various types of nanoparticles that have been the focus of extensive research, elucidates their mechanisms of radiation sensitization, and evaluates the factors influencing the efficiency of this sensitization process. Furthermore, this review discusses the latest synergistic therapeutic strategies that integrate nanoparticle-mediated radiosensitization and outlines prospective directions for the future application of nanoparticles in conjunction with proton therapy. |
| format | Article |
| id | doaj-art-5838be9aaa8d468c8ea03692d3e9f88f |
| institution | OA Journals |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-5838be9aaa8d468c8ea03692d3e9f88f2025-08-20T01:53:49ZengMDPI AGCells2073-44092024-11-011322184110.3390/cells13221841Enhancing Proton Therapy Efficacy Through Nanoparticle-Mediated RadiosensitizationJie Ma0Hao Shen1Zhaohong Mi2Key Laboratory of Nuclear Physics and Ion-Beam Application (MOE), Institute of Modern Physics, Fudan University, Shanghai 200433, ChinaKey Laboratory of Nuclear Physics and Ion-Beam Application (MOE), Institute of Modern Physics, Fudan University, Shanghai 200433, ChinaKey Laboratory of Nuclear Physics and Ion-Beam Application (MOE), Institute of Modern Physics, Fudan University, Shanghai 200433, ChinaProton therapy, characterized by its unique Bragg peak, offers the potential to optimize the destruction of cancer cells while sparing healthy tissues, positioning it as one of the most advanced cancer treatment modalities currently available. However, in comparison to heavy ions, protons exhibit a relatively lower relative biological effectiveness (RBE), which limits the efficacy of proton therapy. The incorporation of nanoparticles for radiosensitization presents a novel approach to enhance the RBE of protons. This review provides a comprehensive discussion of the recent advancements in augmenting the biological effects of proton therapy through the use of nanoparticles. It examines the various types of nanoparticles that have been the focus of extensive research, elucidates their mechanisms of radiation sensitization, and evaluates the factors influencing the efficiency of this sensitization process. Furthermore, this review discusses the latest synergistic therapeutic strategies that integrate nanoparticle-mediated radiosensitization and outlines prospective directions for the future application of nanoparticles in conjunction with proton therapy.https://www.mdpi.com/2073-4409/13/22/1841proton therapynanoparticle radiosensitizationRBEcancer cells |
| spellingShingle | Jie Ma Hao Shen Zhaohong Mi Enhancing Proton Therapy Efficacy Through Nanoparticle-Mediated Radiosensitization Cells proton therapy nanoparticle radiosensitization RBE cancer cells |
| title | Enhancing Proton Therapy Efficacy Through Nanoparticle-Mediated Radiosensitization |
| title_full | Enhancing Proton Therapy Efficacy Through Nanoparticle-Mediated Radiosensitization |
| title_fullStr | Enhancing Proton Therapy Efficacy Through Nanoparticle-Mediated Radiosensitization |
| title_full_unstemmed | Enhancing Proton Therapy Efficacy Through Nanoparticle-Mediated Radiosensitization |
| title_short | Enhancing Proton Therapy Efficacy Through Nanoparticle-Mediated Radiosensitization |
| title_sort | enhancing proton therapy efficacy through nanoparticle mediated radiosensitization |
| topic | proton therapy nanoparticle radiosensitization RBE cancer cells |
| url | https://www.mdpi.com/2073-4409/13/22/1841 |
| work_keys_str_mv | AT jiema enhancingprotontherapyefficacythroughnanoparticlemediatedradiosensitization AT haoshen enhancingprotontherapyefficacythroughnanoparticlemediatedradiosensitization AT zhaohongmi enhancingprotontherapyefficacythroughnanoparticlemediatedradiosensitization |