Mendelian Randomization and Bayesian Colocalization Analysis Implicate Glycoprotein VI as a Potential Drug Target for Cardioembolic Stroke in South Asian Populations

Mendelian Randomization and Bayesian Colocalization Analysis Implicate Glycoprotein VI as a Potential Drug Target for Cardioembolic Stroke in South Asian Populations

Background Circulating plasma proteins are clinically useful biomarkers for stroke risk. We examined the causal links between plasma proteins and stroke risk in individuals of South Asian ancestry. Methods and Results We applied proteome‐wide Mendelian randomization and colocalization approaches to...

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Bibliographic Details
Main Authors: Siwei Wu, Devendra Meena, James Yarmolinsky, Dipender Gill, Alexander Smith, Marie‐Joe Dib, Ganesh Chauhan, Anand Rohatgi, Abbas Dehghan, Ioanna Tzoulaki
Format: Article
Language:English
Published: Wiley 2024-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardioembolic
GP6
Mendelian randomization
South Asian ancestry
stroke
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.035008
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https://www.ahajournals.org/doi/10.1161/JAHA.124.035008

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