Peanut Lectin Histochemistry of Barrett’s Esophagus
Barrett’s epithelium refers to the replacement of the normal stratified squamous epithelium with columnar epithelial cells, possibly as a consequence of chronic reflux of gastric content into the esophagus, and is thought to be a pre-neoplastic disorder with the later development of esophageal adeno...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1989-01-01
|
| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1989/370673 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850224005460525056 |
|---|---|
| author | Hugh J. Freeman |
| author_facet | Hugh J. Freeman |
| author_sort | Hugh J. Freeman |
| collection | DOAJ |
| description | Barrett’s epithelium refers to the replacement of the normal stratified
squamous epithelium with columnar epithelial cells, possibly as a consequence
of chronic reflux of gastric content into the esophagus, and is thought to be a
pre-neoplastic disorder with the later development of esophageal adenocarcinoma.
In this study, biopsy specimens from patients with Barrett’s esophagus
were examined with fluorescein-linked peanut lectin to determine if lectin reactivity,
indicative of a previously reported colon cancer-associated mucin in colonic
polyps, was present in the columnar lined esophagus. In all of the patients
studied, positive but variable labelling with this lectin was present, providing
additional evidence that Barrett’s epithelium represents a heterogeneous preneoplastic
change of the esophagus. |
| format | Article |
| id | doaj-art-582b553d5a804ecd9b83f79fd6d4d2dc |
| institution | OA Journals |
| issn | 0835-7900 |
| language | English |
| publishDate | 1989-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-582b553d5a804ecd9b83f79fd6d4d2dc2025-08-20T02:05:46ZengWileyCanadian Journal of Gastroenterology0835-79001989-01-013518518810.1155/1989/370673Peanut Lectin Histochemistry of Barrett’s EsophagusHugh J. Freeman0Department of Medicine, University Hospital, University of British Columbia, Vancouver, British Columbia, CanadaBarrett’s epithelium refers to the replacement of the normal stratified squamous epithelium with columnar epithelial cells, possibly as a consequence of chronic reflux of gastric content into the esophagus, and is thought to be a pre-neoplastic disorder with the later development of esophageal adenocarcinoma. In this study, biopsy specimens from patients with Barrett’s esophagus were examined with fluorescein-linked peanut lectin to determine if lectin reactivity, indicative of a previously reported colon cancer-associated mucin in colonic polyps, was present in the columnar lined esophagus. In all of the patients studied, positive but variable labelling with this lectin was present, providing additional evidence that Barrett’s epithelium represents a heterogeneous preneoplastic change of the esophagus.http://dx.doi.org/10.1155/1989/370673 |
| spellingShingle | Hugh J. Freeman Peanut Lectin Histochemistry of Barrett’s Esophagus Canadian Journal of Gastroenterology |
| title | Peanut Lectin Histochemistry of Barrett’s Esophagus |
| title_full | Peanut Lectin Histochemistry of Barrett’s Esophagus |
| title_fullStr | Peanut Lectin Histochemistry of Barrett’s Esophagus |
| title_full_unstemmed | Peanut Lectin Histochemistry of Barrett’s Esophagus |
| title_short | Peanut Lectin Histochemistry of Barrett’s Esophagus |
| title_sort | peanut lectin histochemistry of barrett s esophagus |
| url | http://dx.doi.org/10.1155/1989/370673 |
| work_keys_str_mv | AT hughjfreeman peanutlectinhistochemistryofbarrettsesophagus |