A Benzimidazole-Based Fluorescent Probe for the Selective Recognition of Cobalt (II) Ions
Cobalt, a rare element in the Earth’s crust, is widely used in industries due to its hardness and antioxidant properties. It also plays a vital role in physiological functions, being a key component of vitamin B<sub>12</sub>. However, excessive cobalt intake can cause health issues. Dete...
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2025-08-01
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| author | Jing Zhu Hua-Fen Wang Jia-Xiang Zhang Man Wang Yu-Wei Zhuang Zhi-Guang Suo Ye-Wu He Yan-Chang Zhang Min Wei Hai-Yan Zhang |
| author_facet | Jing Zhu Hua-Fen Wang Jia-Xiang Zhang Man Wang Yu-Wei Zhuang Zhi-Guang Suo Ye-Wu He Yan-Chang Zhang Min Wei Hai-Yan Zhang |
| author_sort | Jing Zhu |
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| description | Cobalt, a rare element in the Earth’s crust, is widely used in industries due to its hardness and antioxidant properties. It also plays a vital role in physiological functions, being a key component of vitamin B<sub>12</sub>. However, excessive cobalt intake can cause health issues. Detecting cobalt ions, especially Co<sup>2+</sup>, in food is crucial due to potential contamination from various sources. Fluorescent probes offer high sensitivity, selectivity, a rapid response, and ease of use, making them ideal for the accurate and efficient recognition of Co<sup>2+</sup> in complex samples. In this context, a highly selective fluorescent probe, 2,2′-((3-(1H-benzo[d]imidazol-2-yl)-1,2-phenylene) bis(oxy)) bis(N-(quinolin-8-yl) acetamide) (<b>DQBM-B</b>), was synthesized using chloroacetyl chloride, 8-aminoquinoline, 2,3-dihydroxybenzaldehyde, and benzidine as raw materials for the recognition of Co<sup>2+</sup>. Probe <b>DQBM-B</b> can exhibit fluorescence alone in DMF. However, as the concentration of Co<sup>2+</sup> increased, Photoinduced Electron Transfer (PET) occurred, which quenched the original fluorescence of the probe. Probe <b>DQBM-B</b> shows better selectivity for Co<sup>2+</sup> than other ions with high sensitivity (detection limit: 3.56 μmol L<sup>−1</sup>), and the reaction reaches equilibrium within 30 min. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-58296120cdde43e8913cee5b4f64c96d2025-08-20T03:36:27ZengMDPI AGMolecules1420-30492025-08-013015330910.3390/molecules30153309A Benzimidazole-Based Fluorescent Probe for the Selective Recognition of Cobalt (II) IonsJing Zhu0Hua-Fen Wang1Jia-Xiang Zhang2Man Wang3Yu-Wei Zhuang4Zhi-Guang Suo5Ye-Wu He6Yan-Chang Zhang7Min Wei8Hai-Yan Zhang9Henan Key Laboratory of Cereal and Oil Food Safety Inspection and Control, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, ChinaHenan Key Laboratory of Cereal and Oil Food Safety Inspection and Control, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, ChinaHigh & New Technology Research Center of Henan Academy of Sciences, No. 56 Hongzhuan Road, Zhengzhou 450002, ChinaHigh & New Technology Research Center of Henan Academy of Sciences, No. 56 Hongzhuan Road, Zhengzhou 450002, ChinaHigh & New Technology Research Center of Henan Academy of Sciences, No. 56 Hongzhuan Road, Zhengzhou 450002, ChinaHenan Key Laboratory of Cereal and Oil Food Safety Inspection and Control, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, ChinaHenan Key Laboratory of Cereal and Oil Food Safety Inspection and Control, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, ChinaHigh & New Technology Research Center of Henan Academy of Sciences, No. 56 Hongzhuan Road, Zhengzhou 450002, ChinaHenan Key Laboratory of Cereal and Oil Food Safety Inspection and Control, College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, ChinaHigh & New Technology Research Center of Henan Academy of Sciences, No. 56 Hongzhuan Road, Zhengzhou 450002, ChinaCobalt, a rare element in the Earth’s crust, is widely used in industries due to its hardness and antioxidant properties. It also plays a vital role in physiological functions, being a key component of vitamin B<sub>12</sub>. However, excessive cobalt intake can cause health issues. Detecting cobalt ions, especially Co<sup>2+</sup>, in food is crucial due to potential contamination from various sources. Fluorescent probes offer high sensitivity, selectivity, a rapid response, and ease of use, making them ideal for the accurate and efficient recognition of Co<sup>2+</sup> in complex samples. In this context, a highly selective fluorescent probe, 2,2′-((3-(1H-benzo[d]imidazol-2-yl)-1,2-phenylene) bis(oxy)) bis(N-(quinolin-8-yl) acetamide) (<b>DQBM-B</b>), was synthesized using chloroacetyl chloride, 8-aminoquinoline, 2,3-dihydroxybenzaldehyde, and benzidine as raw materials for the recognition of Co<sup>2+</sup>. Probe <b>DQBM-B</b> can exhibit fluorescence alone in DMF. However, as the concentration of Co<sup>2+</sup> increased, Photoinduced Electron Transfer (PET) occurred, which quenched the original fluorescence of the probe. Probe <b>DQBM-B</b> shows better selectivity for Co<sup>2+</sup> than other ions with high sensitivity (detection limit: 3.56 μmol L<sup>−1</sup>), and the reaction reaches equilibrium within 30 min.https://www.mdpi.com/1420-3049/30/15/3309fluorescent probecobalt ion recognitionbenzimidazole-based |
| spellingShingle | Jing Zhu Hua-Fen Wang Jia-Xiang Zhang Man Wang Yu-Wei Zhuang Zhi-Guang Suo Ye-Wu He Yan-Chang Zhang Min Wei Hai-Yan Zhang A Benzimidazole-Based Fluorescent Probe for the Selective Recognition of Cobalt (II) Ions Molecules fluorescent probe cobalt ion recognition benzimidazole-based |
| title | A Benzimidazole-Based Fluorescent Probe for the Selective Recognition of Cobalt (II) Ions |
| title_full | A Benzimidazole-Based Fluorescent Probe for the Selective Recognition of Cobalt (II) Ions |
| title_fullStr | A Benzimidazole-Based Fluorescent Probe for the Selective Recognition of Cobalt (II) Ions |
| title_full_unstemmed | A Benzimidazole-Based Fluorescent Probe for the Selective Recognition of Cobalt (II) Ions |
| title_short | A Benzimidazole-Based Fluorescent Probe for the Selective Recognition of Cobalt (II) Ions |
| title_sort | benzimidazole based fluorescent probe for the selective recognition of cobalt ii ions |
| topic | fluorescent probe cobalt ion recognition benzimidazole-based |
| url | https://www.mdpi.com/1420-3049/30/15/3309 |
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