Thermogravimetric study of vinpocetine suppository
Introduction. Development of technology is the one of the main stage in creation of new medications. Technological process of suppository manufacturing includes sufficiently long thermoprocessing during suppository base making, addition of the active substances and homogenisation. This makes risk...
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Zaporizhzhia State Medical and Pharmaceutical University
2014-02-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/23834/21368 |
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| author | N. А. Nаgоrnaya V. V. Gladishev B. S. Burlaka |
| author_facet | N. А. Nаgоrnaya V. V. Gladishev B. S. Burlaka |
| author_sort | N. А. Nаgоrnaya |
| collection | DOAJ |
| description | Introduction.
Development of technology is the one of the main stage in creation of new medications. Technological process of suppository manufacturing includes sufficiently long thermoprocessing during suppository base making, addition of the active substances and homogenisation. This makes risk of chemical and physical transformations of active substances and excipients in suppository which can be destroyed and changed pharmacologicaly. Use of thermogravimetric analyses in pharmaceutical technology allows to study possibility of chemical interactions of components in the wide range of temperature.
The aim of this work was to study thermoprocessing effects on suppository base with vinpocetine in temperature range of technological process of suppository manufacturing.
Object.
Vinpocetine rectal suppository (with 0,5% of surface-active substances), active substance (vinpocetine) and excipients (twin 80, cacao oil) were used as the objects of thermogravimetric investigation. Thermogravimetric analyses was carried out on the derivatograph «Shimadzu DTG-60» (Japan) with the platinum-rhodium thermocouple by heating from 25°C to 200°C in the aluminium crucible. α-Al2O3 was used as standard. Heating speed was 10ºС in minute. Model mass was 14,23 – 34,4 mg.
Conclusions.
It was established that cacao oil is thermolabile substance with melting temperature 41,32 ºС. Surface-active substance twin 80 displays thermostability from 30 tо 100ºС. Vinpocetine derivatogramme confirmed its thermostability in temperature range from 30 tо 154 ºС.
Derivatogramme of vinpocetine rectal suppository 0,01 and suppository base displayed the absence of critical temperature lower 100ºС. Insignificant mass loss (0,21%) shows that fact. Investigation of composition over 100ºС wasn’t carried out because these temperatures aren’t used in technological process of suppository manufacturing.
Presence of thermal effects on derivatogramme of vinpocetine rectal suppository coincides with thermal effects of suppository base. That indicates absence of chemical and physical transformations of active substance and excipients in application dosage form. |
| format | Article |
| id | doaj-art-58255f34ab764e6e807668db2e2528cc |
| institution | DOAJ |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2014-02-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-58255f34ab764e6e807668db2e2528cc2025-08-20T03:19:34ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102014-02-011959710.14739/2310-1210.2014.1.23834Thermogravimetric study of vinpocetine suppositoryN. А. Nаgоrnaya V. V. GladishevB. S. BurlakaIntroduction. Development of technology is the one of the main stage in creation of new medications. Technological process of suppository manufacturing includes sufficiently long thermoprocessing during suppository base making, addition of the active substances and homogenisation. This makes risk of chemical and physical transformations of active substances and excipients in suppository which can be destroyed and changed pharmacologicaly. Use of thermogravimetric analyses in pharmaceutical technology allows to study possibility of chemical interactions of components in the wide range of temperature. The aim of this work was to study thermoprocessing effects on suppository base with vinpocetine in temperature range of technological process of suppository manufacturing. Object. Vinpocetine rectal suppository (with 0,5% of surface-active substances), active substance (vinpocetine) and excipients (twin 80, cacao oil) were used as the objects of thermogravimetric investigation. Thermogravimetric analyses was carried out on the derivatograph «Shimadzu DTG-60» (Japan) with the platinum-rhodium thermocouple by heating from 25°C to 200°C in the aluminium crucible. α-Al2O3 was used as standard. Heating speed was 10ºС in minute. Model mass was 14,23 – 34,4 mg. Conclusions. It was established that cacao oil is thermolabile substance with melting temperature 41,32 ºС. Surface-active substance twin 80 displays thermostability from 30 tо 100ºС. Vinpocetine derivatogramme confirmed its thermostability in temperature range from 30 tо 154 ºС. Derivatogramme of vinpocetine rectal suppository 0,01 and suppository base displayed the absence of critical temperature lower 100ºС. Insignificant mass loss (0,21%) shows that fact. Investigation of composition over 100ºС wasn’t carried out because these temperatures aren’t used in technological process of suppository manufacturing. Presence of thermal effects on derivatogramme of vinpocetine rectal suppository coincides with thermal effects of suppository base. That indicates absence of chemical and physical transformations of active substance and excipients in application dosage form.http://zmj.zsmu.edu.ua/article/view/23834/21368suppository manufacturingderivatogramthermogravimetric analysestechnological process |
| spellingShingle | N. А. Nаgоrnaya V. V. Gladishev B. S. Burlaka Thermogravimetric study of vinpocetine suppository Zaporožskij Medicinskij Žurnal suppository manufacturing derivatogram thermogravimetric analyses technological process |
| title | Thermogravimetric study of vinpocetine suppository |
| title_full | Thermogravimetric study of vinpocetine suppository |
| title_fullStr | Thermogravimetric study of vinpocetine suppository |
| title_full_unstemmed | Thermogravimetric study of vinpocetine suppository |
| title_short | Thermogravimetric study of vinpocetine suppository |
| title_sort | thermogravimetric study of vinpocetine suppository |
| topic | suppository manufacturing derivatogram thermogravimetric analyses technological process |
| url | http://zmj.zsmu.edu.ua/article/view/23834/21368 |
| work_keys_str_mv | AT nanagornaya thermogravimetricstudyofvinpocetinesuppository AT vvgladishev thermogravimetricstudyofvinpocetinesuppository AT bsburlaka thermogravimetricstudyofvinpocetinesuppository |