Carbapenem-Resistant, Virulence Plasmid–Harboring Klebsiella pneumoniae, United States
Carbapenem-resistant and virulence plasmid–harboring Klebsiella pneumoniae (pVir-CRKP) has emerged and spread globally, yet clinical investigations from the United States remain limited. We conducted a genomic analysis of 884 unique carbapenem-resistant K. pneumoniae isolates from a multicenter US...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2025-04-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/31/4/24-1396_article |
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| author | Jianping Jiang Tengfei Long Adeline R. Porter Arianne Lovey Annie Lee Jesse Thomas Jacob Cesar A. Arias Robert Bonomo Robert Kalayjian Yanan Zhao Frank R. DeLeo David van Duin Barry N. Kreiswirth Liang Chen |
| author_facet | Jianping Jiang Tengfei Long Adeline R. Porter Arianne Lovey Annie Lee Jesse Thomas Jacob Cesar A. Arias Robert Bonomo Robert Kalayjian Yanan Zhao Frank R. DeLeo David van Duin Barry N. Kreiswirth Liang Chen |
| author_sort | Jianping Jiang |
| collection | DOAJ |
| description |
Carbapenem-resistant and virulence plasmid–harboring Klebsiella pneumoniae (pVir-CRKP) has emerged and spread globally, yet clinical investigations from the United States remain limited. We conducted a genomic analysis of 884 unique carbapenem-resistant K. pneumoniae isolates from a multicenter US cohort and identified 6 pVir-CRKP isolates, including 2 sequence type (ST) 23, 2 ST893, and 2 ST11 isolates. Patients infected with pVir-CRKP experienced high Pitt bacteremia scores and a 33% 30-day mortality rate. The pVir-CRKP isolates exhibited significant sequence variation in virulence genes and plasmids, along with differences in mucoviscosity, capsule production, survival in normal human serum, resistance to killing by human polymorphonuclear neutrophils, and in vivo pathogenicity. Phylogenetic analyses showed that most pVir-CRKP isolates were genetically similar to strains reported from other global regions. The emergence of pVir-CRKP with higher virulence potential and carbapenem resistance in the United States than the predominant carbapenem-resistant K. pneumoniae clone underscores the need for active global surveillance.
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| format | Article |
| id | doaj-art-5823ac86a681444ea293161ba08ab1e2 |
| institution | DOAJ |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-5823ac86a681444ea293161ba08ab1e22025-08-20T02:40:41ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-04-0131476177110.3201/eid3104.241396Carbapenem-Resistant, Virulence Plasmid–Harboring Klebsiella pneumoniae, United StatesJianping JiangTengfei LongAdeline R. PorterArianne LoveyAnnie LeeJesse Thomas JacobCesar A. AriasRobert BonomoRobert KalayjianYanan ZhaoFrank R. DeLeoDavid van DuinBarry N. KreiswirthLiang Chen Carbapenem-resistant and virulence plasmid–harboring Klebsiella pneumoniae (pVir-CRKP) has emerged and spread globally, yet clinical investigations from the United States remain limited. We conducted a genomic analysis of 884 unique carbapenem-resistant K. pneumoniae isolates from a multicenter US cohort and identified 6 pVir-CRKP isolates, including 2 sequence type (ST) 23, 2 ST893, and 2 ST11 isolates. Patients infected with pVir-CRKP experienced high Pitt bacteremia scores and a 33% 30-day mortality rate. The pVir-CRKP isolates exhibited significant sequence variation in virulence genes and plasmids, along with differences in mucoviscosity, capsule production, survival in normal human serum, resistance to killing by human polymorphonuclear neutrophils, and in vivo pathogenicity. Phylogenetic analyses showed that most pVir-CRKP isolates were genetically similar to strains reported from other global regions. The emergence of pVir-CRKP with higher virulence potential and carbapenem resistance in the United States than the predominant carbapenem-resistant K. pneumoniae clone underscores the need for active global surveillance. https://wwwnc.cdc.gov/eid/article/31/4/24-1396_articleKlebsiella pneumoniaecarbapenem resistancebacteriavirulence plasmidpVir-CRKPvirulence |
| spellingShingle | Jianping Jiang Tengfei Long Adeline R. Porter Arianne Lovey Annie Lee Jesse Thomas Jacob Cesar A. Arias Robert Bonomo Robert Kalayjian Yanan Zhao Frank R. DeLeo David van Duin Barry N. Kreiswirth Liang Chen Carbapenem-Resistant, Virulence Plasmid–Harboring Klebsiella pneumoniae, United States Emerging Infectious Diseases Klebsiella pneumoniae carbapenem resistance bacteria virulence plasmid pVir-CRKP virulence |
| title | Carbapenem-Resistant, Virulence Plasmid–Harboring Klebsiella pneumoniae, United States |
| title_full | Carbapenem-Resistant, Virulence Plasmid–Harboring Klebsiella pneumoniae, United States |
| title_fullStr | Carbapenem-Resistant, Virulence Plasmid–Harboring Klebsiella pneumoniae, United States |
| title_full_unstemmed | Carbapenem-Resistant, Virulence Plasmid–Harboring Klebsiella pneumoniae, United States |
| title_short | Carbapenem-Resistant, Virulence Plasmid–Harboring Klebsiella pneumoniae, United States |
| title_sort | carbapenem resistant virulence plasmid harboring klebsiella pneumoniae united states |
| topic | Klebsiella pneumoniae carbapenem resistance bacteria virulence plasmid pVir-CRKP virulence |
| url | https://wwwnc.cdc.gov/eid/article/31/4/24-1396_article |
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