Exploring the role of gut microbiota modulation in the long-term therapeutic benefits of early MSC transplantation in MRL/lpr mice

Exploring the role of gut microbiota modulation in the long-term therapeutic benefits of early MSC transplantation in MRL/lpr mice

Abstract Background Systemic lupus erythematosus (SLE), influenced by gut microbiota dysbiosis, is characterized by autoimmune and inflammatory responses. Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) transplantation is an effective and safe treatment for refractory or severe SLE; how...

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Main Authors: Quanren Pan, Fengbiao Guo, Jiaxuan Chen, Haimin Huang, Yanyan Huang, Shuzhen Liao, Zengzhi Xiao, Xi Wang, Liuyong You, Lawei Yang, Xuemei Huang, Haiyan Xiao, Hua-Feng Liu, Qingjun Pan
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cellular & Molecular Biology Letters
Subjects:
Mesenchymal stem cells
Systemic lupus erythematosus
Gut microbiota
Tryptophan metabolism
Butanoate metabolism
Aryl hydrocarbon receptor
Online Access:https://doi.org/10.1186/s11658-025-00716-8
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