Single-Walled-Carbon-Nanotube-Modified Pyrolytic Graphite Electrode Used as a Simple Sensor for the Determination of Salbutamol in Urine
A fast and sensitive voltammetric method has been proposed for the determination of salbutamol at single-walled-carbon-nanotube-modified edge-plane pyrolytic graphite electrode (SWNT/EPPGE) in human urine. The electrochemical response of salbutamol was determined by square wave voltammetry (SWV) in...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Electrochemistry |
| Online Access: | http://dx.doi.org/10.4061/2011/373498 |
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| author | Rajendra N. Goyal Sunita Bishnoi Bharati Agrawal |
| author_facet | Rajendra N. Goyal Sunita Bishnoi Bharati Agrawal |
| author_sort | Rajendra N. Goyal |
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| description | A fast and sensitive voltammetric method has been proposed for the determination of salbutamol at single-walled-carbon-nanotube-modified edge-plane pyrolytic graphite electrode (SWNT/EPPGE) in human urine. The electrochemical response of salbutamol was determined by square wave voltammetry (SWV) in phosphate buffer solution (PBS) at physiological pH 7.2. The modified electrode showed improved voltammetric response towards the oxidation of salbutamol, and a well-defined anodic peak was observed at ~600 mV with enhanced peak current in comparison to the bare electrode. Linear calibration plot using SWNT/EPPGE was obtained in the concentration range of 50 to 2500 ngml-1 with sensitivity and detection limit of 2.15 nA/ngml-1 and 4.31 ngml-1, respectively. The developed method has been successfully applied for the determination of salbutamol in commercial preparations and human body fluids. Fast analysis of salbutamol in human urine makes the proposed method of great interest for doping control purposes at the site of competitive games. |
| format | Article |
| id | doaj-art-581c8e81e8254e1a870446b130d3b1fb |
| institution | Kabale University |
| issn | 2090-3537 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Electrochemistry |
| spelling | doaj-art-581c8e81e8254e1a870446b130d3b1fb2025-08-20T03:33:38ZengWileyInternational Journal of Electrochemistry2090-35372011-01-01201110.4061/2011/373498373498Single-Walled-Carbon-Nanotube-Modified Pyrolytic Graphite Electrode Used as a Simple Sensor for the Determination of Salbutamol in UrineRajendra N. Goyal0Sunita Bishnoi1Bharati Agrawal2Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, IndiaDepartment of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, IndiaDepartment of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, IndiaA fast and sensitive voltammetric method has been proposed for the determination of salbutamol at single-walled-carbon-nanotube-modified edge-plane pyrolytic graphite electrode (SWNT/EPPGE) in human urine. The electrochemical response of salbutamol was determined by square wave voltammetry (SWV) in phosphate buffer solution (PBS) at physiological pH 7.2. The modified electrode showed improved voltammetric response towards the oxidation of salbutamol, and a well-defined anodic peak was observed at ~600 mV with enhanced peak current in comparison to the bare electrode. Linear calibration plot using SWNT/EPPGE was obtained in the concentration range of 50 to 2500 ngml-1 with sensitivity and detection limit of 2.15 nA/ngml-1 and 4.31 ngml-1, respectively. The developed method has been successfully applied for the determination of salbutamol in commercial preparations and human body fluids. Fast analysis of salbutamol in human urine makes the proposed method of great interest for doping control purposes at the site of competitive games.http://dx.doi.org/10.4061/2011/373498 |
| spellingShingle | Rajendra N. Goyal Sunita Bishnoi Bharati Agrawal Single-Walled-Carbon-Nanotube-Modified Pyrolytic Graphite Electrode Used as a Simple Sensor for the Determination of Salbutamol in Urine International Journal of Electrochemistry |
| title | Single-Walled-Carbon-Nanotube-Modified Pyrolytic Graphite Electrode Used as a Simple Sensor for the Determination of Salbutamol in Urine |
| title_full | Single-Walled-Carbon-Nanotube-Modified Pyrolytic Graphite Electrode Used as a Simple Sensor for the Determination of Salbutamol in Urine |
| title_fullStr | Single-Walled-Carbon-Nanotube-Modified Pyrolytic Graphite Electrode Used as a Simple Sensor for the Determination of Salbutamol in Urine |
| title_full_unstemmed | Single-Walled-Carbon-Nanotube-Modified Pyrolytic Graphite Electrode Used as a Simple Sensor for the Determination of Salbutamol in Urine |
| title_short | Single-Walled-Carbon-Nanotube-Modified Pyrolytic Graphite Electrode Used as a Simple Sensor for the Determination of Salbutamol in Urine |
| title_sort | single walled carbon nanotube modified pyrolytic graphite electrode used as a simple sensor for the determination of salbutamol in urine |
| url | http://dx.doi.org/10.4061/2011/373498 |
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