DNA Mismatch Repair in Eukaryotes and Bacteria
DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to human. The significance of this repair system is also...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.4061/2010/260512 |
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| _version_ | 1850223915328077824 |
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| author | Kenji Fukui |
| author_facet | Kenji Fukui |
| author_sort | Kenji Fukui |
| collection | DOAJ |
| description | DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to human. The significance of this repair system is also indicated by the fact that defects in MMR cause human hereditary nonpolyposis colon cancers as well as sporadic tumors. To date, 2 types of MMRs are known: the human type and Escherichia coli type. The basic features of the former system are expected to be universal among the vast majority of organisms including most bacteria. Here, I review the molecular mechanisms of eukaryotic and bacterial MMR, emphasizing on the similarities between them. |
| format | Article |
| id | doaj-art-581b590355624aee8eff8febf7b4d44e |
| institution | OA Journals |
| issn | 2090-021X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-581b590355624aee8eff8febf7b4d44e2025-08-20T02:05:47ZengWileyJournal of Nucleic Acids2090-021X2010-01-01201010.4061/2010/260512260512DNA Mismatch Repair in Eukaryotes and BacteriaKenji Fukui0RIKEN SPring-8 Center, Harima Institute, 1-1-1 Kouto, Sayo-cho, Sayo-gun, Hyogo 679-5148, JapanDNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to human. The significance of this repair system is also indicated by the fact that defects in MMR cause human hereditary nonpolyposis colon cancers as well as sporadic tumors. To date, 2 types of MMRs are known: the human type and Escherichia coli type. The basic features of the former system are expected to be universal among the vast majority of organisms including most bacteria. Here, I review the molecular mechanisms of eukaryotic and bacterial MMR, emphasizing on the similarities between them.http://dx.doi.org/10.4061/2010/260512 |
| spellingShingle | Kenji Fukui DNA Mismatch Repair in Eukaryotes and Bacteria Journal of Nucleic Acids |
| title | DNA Mismatch Repair in Eukaryotes and Bacteria |
| title_full | DNA Mismatch Repair in Eukaryotes and Bacteria |
| title_fullStr | DNA Mismatch Repair in Eukaryotes and Bacteria |
| title_full_unstemmed | DNA Mismatch Repair in Eukaryotes and Bacteria |
| title_short | DNA Mismatch Repair in Eukaryotes and Bacteria |
| title_sort | dna mismatch repair in eukaryotes and bacteria |
| url | http://dx.doi.org/10.4061/2010/260512 |
| work_keys_str_mv | AT kenjifukui dnamismatchrepairineukaryotesandbacteria |