WTAP suppresses STAT3 via m6A methylation to regulate autophagy and inflammation in central nervous system injury

WTAP suppresses STAT3 via m6A methylation to regulate autophagy and inflammation in central nervous system injury

Central nervous system (CNS) repair after injury is a challenging process limited by inflammation and neuronal apoptosis. This study identifies Wilms' tumor 1-associating protein (WTAP) as a pivotal regulator of neuronal protection and repair through m6A methylation of STAT3 mRNA. By employing...

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Bibliographic Details
Main Authors: Xiaoyong Zhao, Xiaoli Zhang, Liangzhi Wu, Xiaohe Liu, Yongquan Pan, Taiquan Lv, Mingyang Xu, Kongbin Yang, Xiangyu Wang
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Neurobiology of Disease
Subjects:
Wilms' tumor 1-associating protein
m6A methylation
STAT3
Autophagy
NLRP3 signaling pathway
Neuronal injury repair
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000270
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