Health implications of racial differences in serum growth differentiation factor levels among men with obesity
Abstract Growth differentiation factor (GDF15) has been considered a biomarker and recently a hormonal driver for diseases in different populations. However, the role of GDF15 as a biomarker of health outcomes in obese men from different racial/ethnic background has not been evaluated. The objective...
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Wiley
2024-12-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.70124 |
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| author | Siresha Bathina Virginia Fuenmayor Lopez Mia Prado Elliot Ballato Georgia Colleluori Maryam Tetlay Dennis T Villareal Sanjay Mediwala Rui Chen Clifford Qualls Reina Armamento‐Villareal |
| author_facet | Siresha Bathina Virginia Fuenmayor Lopez Mia Prado Elliot Ballato Georgia Colleluori Maryam Tetlay Dennis T Villareal Sanjay Mediwala Rui Chen Clifford Qualls Reina Armamento‐Villareal |
| author_sort | Siresha Bathina |
| collection | DOAJ |
| description | Abstract Growth differentiation factor (GDF15) has been considered a biomarker and recently a hormonal driver for diseases in different populations. However, the role of GDF15 as a biomarker of health outcomes in obese men from different racial/ethnic background has not been evaluated. The objective of this study was to investigate the racial/ethnic differences on the relationship between GDF15 and markers of glucometabolic status, hormonal profile, body composition and bone mineral density (BMD) in obese men. One hundred ninety‐three obese men from diverse racial/ethnic backgrounds were enrolled. BMD and body composition were measured by dual energy X‐ray absorptiometry. Serum GDF15, osteocalcin, C‐terminal telopeptide, sclerostin, adiponectin, leptin, estradiol, testosterone, follicle‐stimulating hormone, luteinizing hormone, 25‐hydroxyvitamin D, lipid profile, and hemoglobin A1C (A1C) were measured. Non‐African Americans (NAA) had significantly higher GDF15 level than African Americans (AA). Level was also higher in patients with type 2 diabetes (T2DM). In both the groups GDF15 correlated with A1C and lean mass. However. GDF15 correlated with body fat, LDL total cholesterol and femoral neck BMD only in NAA and with appendicular lean mass only in AA. Ethnicity, total cholesterol and T2DM were found to be independent predictors of GDF15. We conclude that GDF15 may influence glucometabolic status, body composition and bone parameters which may affect cardiovascular risk and osteoporosis between races. |
| format | Article |
| id | doaj-art-580f5e3403bd437b8fd45299b6aa5139 |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-580f5e3403bd437b8fd45299b6aa51392025-01-10T11:14:29ZengWileyPhysiological Reports2051-817X2024-12-011223n/an/a10.14814/phy2.70124Health implications of racial differences in serum growth differentiation factor levels among men with obesitySiresha Bathina0Virginia Fuenmayor Lopez1Mia Prado2Elliot Ballato3Georgia Colleluori4Maryam Tetlay5Dennis T Villareal6Sanjay Mediwala7Rui Chen8Clifford Qualls9Reina Armamento‐Villareal10Division of Endocrinology Diabetes and Metabolism at Baylor College of Medicine Houston Texas USADivision of Endocrinology Diabetes and Metabolism at Baylor College of Medicine Houston Texas USADivision of Endocrinology Diabetes and Metabolism at Baylor College of Medicine Houston Texas USADivision of Endocrinology Diabetes and Metabolism at Baylor College of Medicine Houston Texas USADivision of Endocrinology Diabetes and Metabolism at Baylor College of Medicine Houston Texas USADivision of Endocrinology Diabetes and Metabolism at Baylor College of Medicine Houston Texas USADivision of Endocrinology Diabetes and Metabolism at Baylor College of Medicine Houston Texas USADivision of Endocrinology Diabetes and Metabolism at Baylor College of Medicine Houston Texas USADivision of Endocrinology Diabetes and Metabolism at Baylor College of Medicine Houston Texas USADepartment of Mathematics and Statistics University of New Mexico Albuquerque New Mexico USADivision of Endocrinology Diabetes and Metabolism at Baylor College of Medicine Houston Texas USAAbstract Growth differentiation factor (GDF15) has been considered a biomarker and recently a hormonal driver for diseases in different populations. However, the role of GDF15 as a biomarker of health outcomes in obese men from different racial/ethnic background has not been evaluated. The objective of this study was to investigate the racial/ethnic differences on the relationship between GDF15 and markers of glucometabolic status, hormonal profile, body composition and bone mineral density (BMD) in obese men. One hundred ninety‐three obese men from diverse racial/ethnic backgrounds were enrolled. BMD and body composition were measured by dual energy X‐ray absorptiometry. Serum GDF15, osteocalcin, C‐terminal telopeptide, sclerostin, adiponectin, leptin, estradiol, testosterone, follicle‐stimulating hormone, luteinizing hormone, 25‐hydroxyvitamin D, lipid profile, and hemoglobin A1C (A1C) were measured. Non‐African Americans (NAA) had significantly higher GDF15 level than African Americans (AA). Level was also higher in patients with type 2 diabetes (T2DM). In both the groups GDF15 correlated with A1C and lean mass. However. GDF15 correlated with body fat, LDL total cholesterol and femoral neck BMD only in NAA and with appendicular lean mass only in AA. Ethnicity, total cholesterol and T2DM were found to be independent predictors of GDF15. We conclude that GDF15 may influence glucometabolic status, body composition and bone parameters which may affect cardiovascular risk and osteoporosis between races.https://doi.org/10.14814/phy2.70124GDF15ObesityA1CCholesterolCardiovascular risk |
| spellingShingle | Siresha Bathina Virginia Fuenmayor Lopez Mia Prado Elliot Ballato Georgia Colleluori Maryam Tetlay Dennis T Villareal Sanjay Mediwala Rui Chen Clifford Qualls Reina Armamento‐Villareal Health implications of racial differences in serum growth differentiation factor levels among men with obesity Physiological Reports GDF15 Obesity A1C Cholesterol Cardiovascular risk |
| title | Health implications of racial differences in serum growth differentiation factor levels among men with obesity |
| title_full | Health implications of racial differences in serum growth differentiation factor levels among men with obesity |
| title_fullStr | Health implications of racial differences in serum growth differentiation factor levels among men with obesity |
| title_full_unstemmed | Health implications of racial differences in serum growth differentiation factor levels among men with obesity |
| title_short | Health implications of racial differences in serum growth differentiation factor levels among men with obesity |
| title_sort | health implications of racial differences in serum growth differentiation factor levels among men with obesity |
| topic | GDF15 Obesity A1C Cholesterol Cardiovascular risk |
| url | https://doi.org/10.14814/phy2.70124 |
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