Preliminary assessment of microcirculation in the ascending aorta in patients with normal and dilated ascending aorta using laser Doppler perfusion monitoring
<b>Background:</b> Microcirculation within the ascending aortic wall, supplied by the vasa vasorum, is increasingly recognized as a potential factor in the pathogenesis of aortic aneurysms. However, in vivo assessment remains challenging. This pilot study aimed to evaluate ascending aort...
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Medical University of Gdańsk
2025-07-01
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| Series: | European Journal of Translational and Clinical Medicine |
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| Online Access: | https://ejtcm.gumed.edu.pl/articles/205392.pdf |
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| author | Mikołaj Krysiak Andrzej Łoś Rafał Pawlaczyk Mateusz Janeczek Marcin Hellmann |
| author_facet | Mikołaj Krysiak Andrzej Łoś Rafał Pawlaczyk Mateusz Janeczek Marcin Hellmann |
| author_sort | Mikołaj Krysiak |
| collection | DOAJ |
| description | <b>Background:</b> Microcirculation within the ascending aortic wall, supplied by the vasa vasorum, is increasingly recognized as a potential factor in the pathogenesis of aortic aneurysms. However, in vivo assessment remains challenging. This pilot study aimed to evaluate ascending aortic microcirculation intraoperatively using Laser Doppler Perfusion Monitoring (LDPM).
<b>Material and methods:</b> Twenty-four patients (18 males, 6 females) undergoing elective cardiac surgery were enrolled. LDPM was performed on the exposed ascending aorta prior to surgical manipulation. A probe was sutured to the aortic wall and perfusion was recorded in Perfusion Units (PU). A brief probe compression test was conducted to evaluate perfusion response.
<b>Results:</b> The mean LDPM value was 281.58 PU (males: 339.94 PU; females: 139.86 PU). In males, LDPM negatively correlated with age (r = –0.593, p = 0.0121), whereas a moderate but non-significant correlation was noted with BMI (r = –0.303, p = 0.2366). No significant associations were observed with hypertension, diabetes, smoking, or aortic dilation. A paradoxical increase in PU during probe compression occurred in 54% of patients.
<b>Conclusions:</b> LDPM provides real-time intraoperative assessment of aortic microcirculation. Age-related decline in perfusion may contribute to aortic wall vulnerability. Further studies with larger cohorts are needed to validate these findings. |
| format | Article |
| id | doaj-art-580e0ea8e7d4474aa76fc46cd3ea9788 |
| institution | Kabale University |
| issn | 2657-3148 2657-3156 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Medical University of Gdańsk |
| record_format | Article |
| series | European Journal of Translational and Clinical Medicine |
| spelling | doaj-art-580e0ea8e7d4474aa76fc46cd3ea97882025-08-20T04:00:13ZengMedical University of GdańskEuropean Journal of Translational and Clinical Medicine2657-31482657-31562025-07-018159205392Preliminary assessment of microcirculation in the ascending aorta in patients with normal and dilated ascending aorta using laser Doppler perfusion monitoringMikołaj Krysiak0https://orcid.org/0000-0001-8022-0895Andrzej Łoś1https://orcid.org/0000-0002-8907-8343Rafał Pawlaczyk2https://orcid.org/0000-0002-4550-1541Mateusz Janeczek3https://orcid.org/0009-0003-6963-2663Marcin Hellmann4https://orcid.org/0000-0003-0403-805XDepartment of Cardiac & Vascular Surgery, Medical University of Gdańsk, PolandDepartment of Cardiac & Vascular Surgery, Medical University of Gdańsk, PolandDepartment of Cardiac & Vascular Surgery, Medical University of Gdańsk, PolandDepartment of Cardiac & Vascular Surgery, Medical University of Gdańsk, PolandDivision of Cardiac Diagnostics, Medical University of Gdańsk, Poland<b>Background:</b> Microcirculation within the ascending aortic wall, supplied by the vasa vasorum, is increasingly recognized as a potential factor in the pathogenesis of aortic aneurysms. However, in vivo assessment remains challenging. This pilot study aimed to evaluate ascending aortic microcirculation intraoperatively using Laser Doppler Perfusion Monitoring (LDPM). <b>Material and methods:</b> Twenty-four patients (18 males, 6 females) undergoing elective cardiac surgery were enrolled. LDPM was performed on the exposed ascending aorta prior to surgical manipulation. A probe was sutured to the aortic wall and perfusion was recorded in Perfusion Units (PU). A brief probe compression test was conducted to evaluate perfusion response. <b>Results:</b> The mean LDPM value was 281.58 PU (males: 339.94 PU; females: 139.86 PU). In males, LDPM negatively correlated with age (r = –0.593, p = 0.0121), whereas a moderate but non-significant correlation was noted with BMI (r = –0.303, p = 0.2366). No significant associations were observed with hypertension, diabetes, smoking, or aortic dilation. A paradoxical increase in PU during probe compression occurred in 54% of patients. <b>Conclusions:</b> LDPM provides real-time intraoperative assessment of aortic microcirculation. Age-related decline in perfusion may contribute to aortic wall vulnerability. Further studies with larger cohorts are needed to validate these findings.https://ejtcm.gumed.edu.pl/articles/205392.pdfascending aortadilatation of ascending aortalaser doppler perfusion monitoring |
| spellingShingle | Mikołaj Krysiak Andrzej Łoś Rafał Pawlaczyk Mateusz Janeczek Marcin Hellmann Preliminary assessment of microcirculation in the ascending aorta in patients with normal and dilated ascending aorta using laser Doppler perfusion monitoring European Journal of Translational and Clinical Medicine ascending aorta dilatation of ascending aorta laser doppler perfusion monitoring |
| title | Preliminary assessment of microcirculation in the ascending aorta in patients with normal and dilated ascending aorta using laser Doppler perfusion monitoring |
| title_full | Preliminary assessment of microcirculation in the ascending aorta in patients with normal and dilated ascending aorta using laser Doppler perfusion monitoring |
| title_fullStr | Preliminary assessment of microcirculation in the ascending aorta in patients with normal and dilated ascending aorta using laser Doppler perfusion monitoring |
| title_full_unstemmed | Preliminary assessment of microcirculation in the ascending aorta in patients with normal and dilated ascending aorta using laser Doppler perfusion monitoring |
| title_short | Preliminary assessment of microcirculation in the ascending aorta in patients with normal and dilated ascending aorta using laser Doppler perfusion monitoring |
| title_sort | preliminary assessment of microcirculation in the ascending aorta in patients with normal and dilated ascending aorta using laser doppler perfusion monitoring |
| topic | ascending aorta dilatation of ascending aorta laser doppler perfusion monitoring |
| url | https://ejtcm.gumed.edu.pl/articles/205392.pdf |
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