Myocardial Recovery versus Myocardial Regeneration: Mechanisms and Therapeutic Modulation
Myocardial recovery is characterized by a return toward normal structure and function of the heart after an injury. Mechanisms of myocardial recovery include restoration and/or adaptation of myocyte structure and function, mitochondrial activity and number, metabolic homeostasis, electrophysiologica...
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| Format: | Article |
| Language: | English |
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Houston Methodist DeBakey Heart & Vascular Center
2024-08-01
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| Series: | Methodist DeBakey Cardiovascular Journal |
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| Online Access: | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1400 |
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| _version_ | 1849329972263518208 |
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| author | John P. Cooke Keith A. Youker Li Lai |
| author_facet | John P. Cooke Keith A. Youker Li Lai |
| author_sort | John P. Cooke |
| collection | DOAJ |
| description | Myocardial recovery is characterized by a return toward normal structure and function of the heart after an injury. Mechanisms of myocardial recovery include restoration and/or adaptation of myocyte structure and function, mitochondrial activity and number, metabolic homeostasis, electrophysiological stability, extracellular matrix remodeling, and myocardial perfusion. Myocardial regeneration is an element of myocardial recovery that involves the generation of new myocardial tissue, a process which is limited in adult humans but may be therapeutically augmented. Understanding the mechanisms of myocardial recovery and myocardial regeneration will lead to novel therapies for heart failure. |
| format | Article |
| id | doaj-art-580c5e42e9274f30bdda3f2bfebc9f80 |
| institution | Kabale University |
| issn | 1947-6108 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Houston Methodist DeBakey Heart & Vascular Center |
| record_format | Article |
| series | Methodist DeBakey Cardiovascular Journal |
| spelling | doaj-art-580c5e42e9274f30bdda3f2bfebc9f802025-08-20T03:47:06ZengHouston Methodist DeBakey Heart & Vascular CenterMethodist DeBakey Cardiovascular Journal1947-61082024-08-01204314110.14797/mdcvj.14001378Myocardial Recovery versus Myocardial Regeneration: Mechanisms and Therapeutic ModulationJohn P. Cooke0https://orcid.org/0000-0003-0033-9138Keith A. Youker1https://orcid.org/0000-0003-2535-7973Li Lai2https://orcid.org/0000-0002-5731-2705Houston Methodist Academic Institute, Houston, TexasHouston Methodist Academic Institute, Houston, TexasHouston Methodist Academic Institute, Houston, TexasMyocardial recovery is characterized by a return toward normal structure and function of the heart after an injury. Mechanisms of myocardial recovery include restoration and/or adaptation of myocyte structure and function, mitochondrial activity and number, metabolic homeostasis, electrophysiological stability, extracellular matrix remodeling, and myocardial perfusion. Myocardial regeneration is an element of myocardial recovery that involves the generation of new myocardial tissue, a process which is limited in adult humans but may be therapeutically augmented. Understanding the mechanisms of myocardial recovery and myocardial regeneration will lead to novel therapies for heart failure.https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1400myocardial recoverycardiovascular regenerationleft ventricular assist devices (lvads)mesenchymal to endothelial cell transition (mendot)metabolism |
| spellingShingle | John P. Cooke Keith A. Youker Li Lai Myocardial Recovery versus Myocardial Regeneration: Mechanisms and Therapeutic Modulation Methodist DeBakey Cardiovascular Journal myocardial recovery cardiovascular regeneration left ventricular assist devices (lvads) mesenchymal to endothelial cell transition (mendot) metabolism |
| title | Myocardial Recovery versus Myocardial Regeneration: Mechanisms and Therapeutic Modulation |
| title_full | Myocardial Recovery versus Myocardial Regeneration: Mechanisms and Therapeutic Modulation |
| title_fullStr | Myocardial Recovery versus Myocardial Regeneration: Mechanisms and Therapeutic Modulation |
| title_full_unstemmed | Myocardial Recovery versus Myocardial Regeneration: Mechanisms and Therapeutic Modulation |
| title_short | Myocardial Recovery versus Myocardial Regeneration: Mechanisms and Therapeutic Modulation |
| title_sort | myocardial recovery versus myocardial regeneration mechanisms and therapeutic modulation |
| topic | myocardial recovery cardiovascular regeneration left ventricular assist devices (lvads) mesenchymal to endothelial cell transition (mendot) metabolism |
| url | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1400 |
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