Sodium Silicate, Potassium Silicate, and Copper Sulfate’s Effectiveness In Vitro and In Silico against the Wood-decaying Fungus Phanerochaete chrysosporium
Wood modification via silicon ingredients was investigated to increase its resistance to biological decay. Surfactant and desiccant features of derived products of silicates are considered the main contributors in wood resistance to decay. The detected fungus from decayed wood sample was identified...
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North Carolina State University
2025-07-01
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| Online Access: | https://ojs.bioresources.com/index.php/BRJ/article/view/24695 |
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| author | Mohammed Ibrahim Alghonaim Sulaiman A. Alsalamah Suha Alharbi Abeer Mahmoud Mohammad |
| author_facet | Mohammed Ibrahim Alghonaim Sulaiman A. Alsalamah Suha Alharbi Abeer Mahmoud Mohammad |
| author_sort | Mohammed Ibrahim Alghonaim |
| collection | DOAJ |
| description | Wood modification via silicon ingredients was investigated to increase its resistance to biological decay. Surfactant and desiccant features of derived products of silicates are considered the main contributors in wood resistance to decay. The detected fungus from decayed wood sample was identified as Phanerochaete chrysosporium. Inhibitory tests showed that sodium silicate (SS) was more effective than potassium silicate (PS) and copper sulfate (CS) against P. chrysosporium growth. The weight loss of infected wood with P. chrysosporium without treatment was 32.2%, while treatment by SS, PS, and CS reduced weight loss to 4.3%, 11.5%, and 14.3%, respectively, over 40 days. To ducument the effect of SS, PS, and CS on P. chrysosporium, molecular docking was used to evaluate the binding interactions of these compounds with the active site (Lignin peroxidase) of P. chrysosporium (PDB ID: 1QPA). Binding affinities were determined via docking scores, conformational energies, placement energies, and refinement parameters evaluation. SS exhibited the strongest docking scores (S = -6.17 to -5.83) and favorable interactions, including metal coordination and hydrogen bonding. PS and CS showed moderate to weak binding, with distinct interaction patterns. These computational results highlight SS as a potential candidate for further experimental validation in targeting the 1QPA protein. |
| format | Article |
| id | doaj-art-5809c6f3b2ea4ffca614a2a1988d9834 |
| institution | Kabale University |
| issn | 1930-2126 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | North Carolina State University |
| record_format | Article |
| series | BioResources |
| spelling | doaj-art-5809c6f3b2ea4ffca614a2a1988d98342025-08-20T04:00:33ZengNorth Carolina State UniversityBioResources1930-21262025-07-01203565056633324Sodium Silicate, Potassium Silicate, and Copper Sulfate’s Effectiveness In Vitro and In Silico against the Wood-decaying Fungus Phanerochaete chrysosporiumMohammed Ibrahim Alghonaim0https://orcid.org/0000-0001-8391-7700Sulaiman A. Alsalamah1https://orcid.org/0009-0005-6636-8961Suha Alharbi2Abeer Mahmoud Mohammad3https://orcid.org/0000-0003-3309-048XDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11623 Riyadh, Saudi ArabiaDepartment of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), 11623 Riyadh, Saudi ArabiaDepartment of Biology, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaBiology Department, Al-Darb University College, Jazan University, Jazan, Saudi ArabiaWood modification via silicon ingredients was investigated to increase its resistance to biological decay. Surfactant and desiccant features of derived products of silicates are considered the main contributors in wood resistance to decay. The detected fungus from decayed wood sample was identified as Phanerochaete chrysosporium. Inhibitory tests showed that sodium silicate (SS) was more effective than potassium silicate (PS) and copper sulfate (CS) against P. chrysosporium growth. The weight loss of infected wood with P. chrysosporium without treatment was 32.2%, while treatment by SS, PS, and CS reduced weight loss to 4.3%, 11.5%, and 14.3%, respectively, over 40 days. To ducument the effect of SS, PS, and CS on P. chrysosporium, molecular docking was used to evaluate the binding interactions of these compounds with the active site (Lignin peroxidase) of P. chrysosporium (PDB ID: 1QPA). Binding affinities were determined via docking scores, conformational energies, placement energies, and refinement parameters evaluation. SS exhibited the strongest docking scores (S = -6.17 to -5.83) and favorable interactions, including metal coordination and hydrogen bonding. PS and CS showed moderate to weak binding, with distinct interaction patterns. These computational results highlight SS as a potential candidate for further experimental validation in targeting the 1QPA protein.https://ojs.bioresources.com/index.php/BRJ/article/view/24695wood biodegradationwood fungal protectionsilicate treatmentsdocking interaction |
| spellingShingle | Mohammed Ibrahim Alghonaim Sulaiman A. Alsalamah Suha Alharbi Abeer Mahmoud Mohammad Sodium Silicate, Potassium Silicate, and Copper Sulfate’s Effectiveness In Vitro and In Silico against the Wood-decaying Fungus Phanerochaete chrysosporium BioResources wood biodegradation wood fungal protection silicate treatments docking interaction |
| title | Sodium Silicate, Potassium Silicate, and Copper Sulfate’s Effectiveness In Vitro and In Silico against the Wood-decaying Fungus Phanerochaete chrysosporium |
| title_full | Sodium Silicate, Potassium Silicate, and Copper Sulfate’s Effectiveness In Vitro and In Silico against the Wood-decaying Fungus Phanerochaete chrysosporium |
| title_fullStr | Sodium Silicate, Potassium Silicate, and Copper Sulfate’s Effectiveness In Vitro and In Silico against the Wood-decaying Fungus Phanerochaete chrysosporium |
| title_full_unstemmed | Sodium Silicate, Potassium Silicate, and Copper Sulfate’s Effectiveness In Vitro and In Silico against the Wood-decaying Fungus Phanerochaete chrysosporium |
| title_short | Sodium Silicate, Potassium Silicate, and Copper Sulfate’s Effectiveness In Vitro and In Silico against the Wood-decaying Fungus Phanerochaete chrysosporium |
| title_sort | sodium silicate potassium silicate and copper sulfate s effectiveness in vitro and in silico against the wood decaying fungus phanerochaete chrysosporium |
| topic | wood biodegradation wood fungal protection silicate treatments docking interaction |
| url | https://ojs.bioresources.com/index.php/BRJ/article/view/24695 |
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